Patents by Inventor Edmund E. Marinelli

Edmund E. Marinelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Linkable sialyl Lewis X analogs
    Patent number: 7422733
    Abstract: Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLeX) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLeX compositions. In particular, the disclosed SLeX compounds can be used to prepare selectin binding ligand conjugates by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLeX compounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl Lex, and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: September 9, 2008
    Assignee: Bracco International B.V.
    Inventors: Ramachandran Ranganathan, Kondareddiar Ramalingam, Radhakrishua Pillai, Edmund E. Marinelli, Rolf E. Swenson
  • Linkable sialyl lewis x analogs
    Publication number: 20040097403
    Abstract: Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLeX) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLeX compositions. In particular, the disclosed SLeX compounds can be used to prepare selectin binding ligand conjugates by linking them to a reporter moiety, such as a contrast agent, a radiodiagnostic agent, or a cytotoxic or chemotherapeutic agent. The SLeX compounds and conjugates of the invention exhibit binding to selectin that is similar to native Sialyl Lex, and are, therefore, useful for diagnosing and treating selectin-mediated disorders and related conditions.
    Type: Application
    Filed: November 17, 2003
    Publication date: May 20, 2004
    Inventors: Ramachandran Ranganathan, Kondareddiar Ramalingam, Radhakrishua Pillai, Edmund E. Marinelli, Rolf E. Swenson