Abstract: This disclosure pertains to a consumable product (microplate) suitable for use in assays utilizing single-molecule recognition through equilibrium Poisson sampling (SiMREPS) and in other assays employing total internal reflection fluorescence (TIRF) or HiLo microscopy. The disclosed microplate is also suitable for use in other high throughput assay systems, such as single-molecule FRET, ligand-receptor binding studies, membrane biology assays, cell-based TIRF and near-TIRF assays. The disclosure further pertains to the use of the microfluidic microplate for the detection of analytes, including nucleic acids, polypeptides, carbohydrates, lipids, post-translational modifications, amino acids, metabolites, and small molecules.

Abstract: Provided herein is technology relating to detection of analytes and particularly, but not exclusively, to compositions, methods, and systems for concentrating an analyte at a surface, e.g., for imaging and detection of low-abundance analytes.

Abstract: Provided is a method and system that includes a plurality of computing modules each configured to (i) retrieve maintenance history and equipment parameters associated with a plurality of equipment components from at least one network and process the maintenance history, (ii) calculate usage intensity based on the maintenance history and equipment parameters, and (iii) create modified maintenance schedules of the plurality of equipment components based on the maintenance history and usage intensity calculated.

Abstract: Provided herein is technology relating to the detection of analytes and particularly, but not exclusively, to methods, systems, compositions, and kits for detecting analytes such as nucleic acids, proteins, small molecules, and other molecules using a technology based on the transient binding of detection probes.

Abstract: The invention discloses a sample preservation method which comprises the following steps: a) providing a paper substrate comprising ligands, where the ligands comprise charged groups, b) applying a sample comprising at least one analyte and at least one contaminant on the paper substrate, c) drying the sample on the paper substrate and, d) extracting at least part of the paper substrate to provide a solution of the analyte.

Abstract: The invention discloses a sample preservation method which comprises the following steps: a) providing a paper substrate comprising ligands, where the ligands comprise charged groups, b) applying a sample comprising at least one analyte and at least one contaminant on the paper substrate, c) drying the sample on the paper substrate and, d) extracting at least part of the paper substrate to provide a solution of the analyte.

Abstract: A data structure embodied in a computer-readable storage medium for configuring connections from a local workstation between a file system residing on the local workstation and a file system residing on a remote host system. The data structure provides for such configuration by allowing the user to specify the host system, specify a host directory path within the host file system, and specify a mapping between a file within the host directory path on the host file system and a file on the local file system. After such configuration, the user may access the host file system file in the same manner as a local file system file. The data structure can encode information describing a file system connection between a local system and a host system in a metalanguage format comprising one or more tags, each tag having an identifier and a set of one or more attributes, wherein the encoded information comprises a file system connection descriptor which can be parsed according to the metalanguage tags.

Abstract: A wave energy device in the form of a self buoyant heave-resistant vessel (10) comprising two or more discrete flow paths into which water can be urged by wave action and a bi-directional energy extractor in fluid communication with said path(s) and atmosphere, arranged to extract energy from air movements in said path(s) caused by said wave action.