Patents by Inventor Edmund Marinelli
Edmund Marinelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11826319Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).Type: GrantFiled: September 16, 2020Date of Patent: November 28, 2023Assignee: NuvOx Pharma LLCInventors: Evan C. Unger, Edmund Marinelli
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Publication number: 20210023021Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).Type: ApplicationFiled: September 16, 2020Publication date: January 28, 2021Inventors: Evan C. Unger, Edmund Marinelli
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Patent number: 10780060Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).Type: GrantFiled: August 15, 2016Date of Patent: September 22, 2020Assignee: NuvOx Pharma LLCInventors: Evan C. Unger, Edmund Marinelli
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Publication number: 20200172908Abstract: The invention provides a composition which includes a shell comprising at least one lipid, wherein said shell defines an enclosed space, a gas disposed within the enclosed space, and a coating of a polyalkylene glycol attached to and extending outwardly from lipid shell, wherein the lipid shell has a diameter from about 30 nanometers to about 5 microns.Type: ApplicationFiled: January 6, 2020Publication date: June 4, 2020Inventors: Evan C. Unger, Edmund Marinelli, Delphine El Mehdi, Paul K. Olson
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Publication number: 20180221302Abstract: The invention provides devices and methods for adjusting particle size in nanoemulsions of fluorocarbons and perfluorocarbons (e.g., perfluoropentane and perfluorohexane) via sonication (e.g., ultrasonication).Type: ApplicationFiled: August 15, 2016Publication date: August 9, 2018Inventors: Evan C. Unger, Edmund Marinelli
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Patent number: 8444954Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.Type: GrantFiled: December 2, 2010Date of Patent: May 21, 2013Assignee: Bracco Imaging S.p.A.Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian Nunn, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
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Patent number: 8420053Abstract: Improved compounds for use in diagnostic imaging or therapy having the formula M-N-O-P-G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N-O-P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound are further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.Type: GrantFiled: August 31, 2009Date of Patent: April 16, 2013Assignee: Bracco Imaging S.p.A.Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
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Publication number: 20120009122Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.Type: ApplicationFiled: December 2, 2010Publication date: January 12, 2012Applicant: BRACCO IMAGING S.P.A.Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael F. Tweedle
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Patent number: 7922998Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.Type: GrantFiled: June 24, 2005Date of Patent: April 12, 2011Assignee: Bracco Imaging S.p.A.Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
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Publication number: 20110052491Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M—N—O—P—G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.Type: ApplicationFiled: August 31, 2009Publication date: March 3, 2011Applicant: BRACCO IMAGING S.P.A.Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
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Patent number: 7850947Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are define herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.Type: GrantFiled: February 10, 2006Date of Patent: December 14, 2010Assignee: Bracco Imaging S.p.A.Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael F. Tweedle
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Patent number: 7611692Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M—N—O—P—G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.Type: GrantFiled: April 20, 2004Date of Patent: November 3, 2009Assignee: Bracco Imaging S.p.A.Inventors: Enrico Cappelletti, Luciano Lattuada, Karen E. Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Kondareddiar Ramalingam, Rolf E. Swenson, Michael Tweedle
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Publication number: 20080008649Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.Type: ApplicationFiled: May 21, 2007Publication date: January 10, 2008Applicant: BRACCO IMAGING S.P.A.Inventors: Enrico Cappelletti, Luciano Lattuada, Karen Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian Nunn, Natarajan Raju, Kondareddiar Ramalingam, Rolf Swenson, Michael Tweedle, Mary Maddalena
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Publication number: 20070269375Abstract: Stabilized radiopharmaceutical formulations are disclosed. Methods of making and using stabilized radiopharmaceutical formulations are also disclosed. The invention relates to stabilizers that improve the radiostability of radiotherapeutic and radiodiagnostic compounds, and formulations containing them. In particular, it relates to stabilizers useful in the preparation and stabilization of targeted radiodiagnostic and radiotherapeutic compounds, and, in a preferred embodiment, to the preparation and stabilization of radiodiagnostic and radiotherapeutic compounds that are targeted to the Gastrin Releasing Peptide Receptor (GRP-Receptor).Type: ApplicationFiled: July 23, 2004Publication date: November 22, 2007Applicant: Bracco Imaging S.p.A.Inventors: Jianqing Chen, Karen Linder, Edmund Marinelli, Edmund Metcalfe, Adrian Nunn, Rolf Swenson, Michael Tweedle
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Publication number: 20070243139Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.Type: ApplicationFiled: January 19, 2007Publication date: October 18, 2007Applicants: BRACCO INTERNATIONAL B.V., DYAX CORPORATIONInventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian Nunn, Radhakrishna Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf Swenson, Mathew Von Wronski, Aaron Sato, Sharon Walker, Daniel Dransfield
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Publication number: 20070231257Abstract: New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N—O—P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.Type: ApplicationFiled: August 25, 2006Publication date: October 4, 2007Applicant: BRACCO IMAGING S.P.A.Inventors: Enrico Cappelletti, Luciano Lattuada, Karen Linder, Edmund Marinelli, Palaniappa Nanjappan, Natarajan Raju, Rolf Swenson, Michael Tweedle
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Publication number: 20070172428Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.Type: ApplicationFiled: March 21, 2007Publication date: July 26, 2007Applicants: BRACCO INTERNATIONAL B.V., DYAX CORPORATIONInventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian Nunn, Radhakrishna Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf Swenson, Mathew Von Wronski, Aaron Sato, Sharon Walker, Daniel Dransfield
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Publication number: 20060263303Abstract: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.Type: ApplicationFiled: May 5, 2006Publication date: November 23, 2006Applicant: Bracco International BVInventors: Mathew Von Wronski, Edmund Marinelli, Adrian Nunn, Radhakrishna Pillai, Kondareddiar Ramalingam, Michael Tweedle, Karen Linder, Palaniappa Nanjappan, Natarajan Raju
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Publication number: 20060258566Abstract: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.Type: ApplicationFiled: May 5, 2006Publication date: November 16, 2006Applicant: Bracco International BVInventors: Mathew Von Wronski, Edmund Marinelli, Adrian Nunn, Radhakrishna Pillai, Kondareddiar Ramalingam, Michael Tweedle, Karen Linder, Palaniappa Nanjappan, Natarajan Raju
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Publication number: 20060239914Abstract: New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.Type: ApplicationFiled: February 10, 2006Publication date: October 26, 2006Applicant: Bracco Imaging S.p.A.Inventors: Enrico Cappelletti, Luciano Lattuada, Karen Linder, Edmund Marinelli, Palaniappa Nanjappan, Adrian Nunn, Natarajan Raju, Kondareddiar Ramalingam, Rolf Swenson, Michael Tweedle