Abstract: The disclosure provides BRD9 bifunctional compounds of Formula (A), (BF-I), (BF-II), (BF-III), (BF-IIIa), (BF-IIIb), (BF-IV), (BF-IVa), (BF-IVb), (BF-I?), (BF-II?), (BF-III?), (BF-IV?), or (BF-V?), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, to their preparation, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases and disorders mediated by a bromodomain-containing protein, such as bromodomain-containing protein 9 (BRD9).

Abstract: Systems and methods for presenting application performance monitoring data in distributed computer systems. An example method may comprise: receiving, by a processing device, one or more application performance monitoring (APM) rules, each APM rule determining an application operational status based on one or more APM parameters; receiving APM data comprising a plurality of APM data items representing values of the APM parameters of a software application; determining an operational status of the software application by applying the APM rules to the APM data; and causing the operational status to be visually represented via a graphical user interface (GUI).

Abstract: Systems and methods for presenting application performance monitoring data in distributed computer systems. An example method may comprise: receiving, by a processing device, one or more application performance monitoring (APM) rules, each APM rule determining an application operational status based on one or more APM parameters; receiving APM data comprising a plurality of APM data items representing values of the APM parameters of a software application; determining an operational status of the software application by applying the APM rules to the APM data; and causing the operational status to be visually represented via a graphical user interface (GUI).

Abstract: The present invention includes novel methods of treating a disease or disorder characterized by hyperactivity of Vps34, and compound as Vps34 inhibitors; particularly compounds of Formula I or a pharmaceutically acceptable salt thereof, as well as methods of treating a disease, disorder, or syndrome associated with Vps34 inhibition, particularly hyperproliferative diseases. The present invention also includes pharmaceutical compositions including compounds of formula I and pharmaceutically acceptable salts thereof.

Abstract: The present invention includes novel methods of treating a disease or disorder characterized by hyperactivity of Vps34, and compound as Vps34 inhibitors; particularly compounds of Formula I or a pharmaceutically acceptable salt thereof, as well as methods of treating a disease, disorder, or syndrome associated with Vps34 inhibition, particularly hyperproliferative diseases. The present invention also includes pharmaceutical compositions including compounds of formula I and pharmaceutically acceptable salts thereof.

Abstract: A circuit configuration having a detection unit designed to generate an output signal that is representative of a load current of a transistor switch, depending on an input signal that is representative of the load current of the transistor switch. The detection unit includes a temperature compensation unit that is designed to take into account the temperature of the transistor switch. The detection unit further includes a delay unit that is designed to delay the detection of the input signal until a prescribed switch-on time period, relative to a switch-on procedure of the transistor switch, has passed. The detection unit is designed in an application-specific integrated circuit.

Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Abstract: A circuit configuration having a detection unit designed to generate an output signal that is representative of a load current of a transistor switch, depending on an input signal that is representative of the load current of the transistor switch. The detection unit includes a temperature compensation unit that is designed to take into account the temperature of the transistor switch. The detection unit further includes a delay unit that is designed to delay the detection of the input signal until a prescribed switch-on time period, relative to a switch-on procedure of the transistor switch, has passed. The detection unit is designed in an application-specific integrated circuit.

Abstract: The invention relates to novel imidazopyridine derivatives and to their use in the treatment of diseases and disorders which may e.g. involve angiogenesis and/or pain, including autoimmune and inflammatory diseases.

Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Abstract: A statistical approach to estimating software execution times is implemented by preparing a model of a target processing device, correlating the software to be estimated to benchmark programs used in the preparation of the model, and then applying the software to be estimated to the model. The model is developed by determining the actual execution times of the benchmark programs, determining a number of virtual instructions in the benchmark programs and determining a predictor equation that correlates the virtual instructions to the actual execution time. The predictor equation is determined by a linear regression technique that includes a correlation analysis of the virtual instructions, removal of highly correlated instructions, and a combination of stepwise linear regression and multiple linear regression to determine the predictor equation.

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Abstract: The present invention relates to inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Abstract: A method of reconizing a fault current in a control unit and to a control unit having a circuit for recognizing the fault current. According to the invention, a current flowing into the control unit which could cause the control unit to be damaged or to operate incorrectly is detected and a fault signal is produced depending on the current detected, the fault signal causing the load or the current supply for the control unit to be switched off, for example.

Abstract: A statistical approach to estimating software execution times is implemented by preparing a model of a target processing device, correlating the software to be estimated to benchmark programs used in the preparation of the model, and then applying the software to be estimated to the model. The model is developed by determining the actual execution times of the benchmark programs, determining a number of virtual instructions in the benchmark programs and determining a predictor equation that correlates the virtual instructions to the actual execution time. The predictor equation is determined by a linear regression technique that includes a correlation analysis of the virtual instructions, removal of highly correlated instructions, and a combination of stepwise linear regression and multiple linear regression to determine the predictor equation. A 2-sample t-test is utilized to evaluate whether the software to be capable of being estimated by the model developed from the benchmark programs.

Abstract: The invention relates to a method of recognizing a fault current in a control unit and to a control unit having a circuit for recognizing the fault current. According to the invention, a current flowing into the control unit which could cause the control unit to be damaged or to operate incorrectly is detected and a fault signal is produced depending on the current detected, the fault signal causing the load or the current supply for the control unit to be switched off, for example.

Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The compounds are of the class of pyrido [1,2-c] pyrimidin-3-one or 1,2-dihydro-pyrido [1,2-c] pyrimidin-3-one derivatives, useful as inhibitors of p38. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Abstract: The grate element (1, 2) is made in three pieces in the sample embodiment, and consists of a central main part (10) and two side parts (11, 12) attached thereto. The main part (10) is pierced by parallel straight-line bores, which form the straight-line conduit sections. These straight-line conduit sections (13) are flow-connected with reversers (14) in the respective side parts (11, 12). The inlet (15) for the coolant fluid is located in the rear part of the grate element, whereas the outlet (16) is located in the head area (7) of the grate element. In the outlet (16) there is a temperature probe (17) for monitoring the temperature of the coolant fluid. The grate element head (7) has recesses (18) in its foot (8) which open downward, serving as air escape orifices for the primary air, which is supplied from beneath.

Abstract: A method for burning fuels, particularly garbage, in incinerators with a stoker grate, for which the primary air is supplied below the stoker grate into the fuel layer and the secondary air is supplied above the fuel layer, is controlled in such a way that the intensity of the combustion of the fuel on the stoker grate is increased by increasing the oxygen content of the primary air and the intensity of the combustion in the secondary combustion zone is choked by decreasing the oxygen content in the secondary air. Flue gas, preferably from the combustion process, is recirculated in order to reduce the oxygen content of the secondary air.