Publication number: 20220315578
Abstract: The disclosure provides BRD9 bifunctional compounds of Formula (A), (BF-I), (BF-II), (BF-III), (BF-IIIa), (BF-IIIb), (BF-IV), (BF-IVa), (BF-IVb), (BF-I?), (BF-II?), (BF-III?), (BF-IV?), or (BF-V?), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, to their preparation, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases and disorders mediated by a bromodomain-containing protein, such as bromodomain-containing protein 9 (BRD9).
Type:
Application
Filed:
September 14, 2020
Publication date:
October 6, 2022
Inventors:
Xin CHEN, Marie-Line GOUDE, Edmund Martin HARRINGTON, Gregory John HOLLINGWORTH, Julien LORBER, Martin SENDZIK, Anna VULPETTI, Thomas ZOLLER