Abstract: Introduced here is an approach to further refining an initial set of target locations that can serve as inputs to machine learning mechanisms. These target locations may refer to unique molecular positions in a reference human genome and/or mutations thereof that are diagnostically relevant for a given cancer type. The system can implement a refinement mechanism to account for unnecessary or problematic data, such as consecutive/overlapping patterns, non-uniform read counts, insufficient data quality, internal processing noises, and/or insufficient data counts.

Abstract: Introduced here is an approach to further refining an initial set of target locations that can serve as inputs to machine learning mechanisms. These target locations may refer to unique molecular positions in a reference human genome and/or mutations thereof that are diagnostically relevant for a given cancer type. The system can implement a refinement mechanism to account for unnecessary or problematic data, such as consecutive/overlapping patterns, non-uniform read counts, insufficient data quality, internal processing noises, and/or insufficient data counts.

Abstract: Introduced here is an approach that can be implemented by a computing system to remove kit-specific signals from genetic information to be analyzed, such that cancer presence, progression, or regression can be predicted in an improved manner. The computing system can “preprocess” the genetic information so that diagnoses can be more accurately predicted in a largely, if not entirely, kit-agnostic manner. The computing system may apply one or more models to genetic information as part of an inferencing operation in order to produce one or more outputs, each of which may be indicative of a proposed diagnosis for the corresponding individual. “Preprocessing” could also be performed on the genetic information that is used to train these models, such that the kit-specific signals are removed before a training operation is completed.

Abstract: Disclosed are systems, methods, and computer-readable media for determining a distribution of various visiting frequencies among devices/elements detected at a site. A method includes generating a list representing a portion of devices detected at a site over a first time period based on wireless signals transmitted by the devices and received at an access point and determining a visiting frequency for each device represented in the list based on data representing devices previously detected at the site. The method further includes, based on the visiting frequency determined for each device represented in the list, estimating a distribution of each visiting frequency among the devices detected at the site over the first time period to yield a plurality of estimated distributions and storing the plurality of estimated distributions for further processing.

Abstract: Disclosed are systems, methods, and computer-readable media for determining a distribution of various visiting frequencies among devices/elements detected at a site. A method includes generating a list representing a portion of devices detected at a site over a first time period based on wireless signals transmitted by the devices and received at an access point and determining a visiting frequency for each device represented in the list based on data representing devices previously detected at the site. The method further includes, based on the visiting frequency determined for each device represented in the list, estimating a distribution of each visiting frequency among the devices detected at the site over the first time period to yield a plurality of estimated distributions and storing the plurality of estimated distributions for further processing.

Abstract: A apparatus for treatment of acute or chronic pain comprising a pain relief treatment device applicable to a soft tissue injury at the periosteal-osseous boundary, and a device for immobilization of the area of soft tissue injury after application of the treatment device. Pain treatment may comprise injection of anti-inflammatory agent, including but not limited to steroids, and/or anesthetics; or low power laser irradiation, or cold treatment to the area of soft tissue injury. Immobilization devices for the cervical and lumbar vertebrae are provided for promoting healing of treated soft tissue injury sites. The invention includes a packaged set of materials comprising a pain relief treatment device, and an external supportive device for immobilizing the soft tissue injury at the site of treatment.

Abstract: A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

Abstract: An assembly enabling detachable fitting of a pair of auxiliary lenses to a pair of primary spectacles; the assembly including a pair of projections on a primary spectacle frame each having a recess or opening which each receive a corresponding projection on an auxiliary frame which holds the pair of auxiliary lenses. The arrangement is such that each projection on the auxiliary frame positively engages an opening on a corresponding projection on the primary spectacle frame.

Abstract: An architecture for a modular communications system is disclosed. The modular communications system comprises at least one control module; a plurality of resource modules for receipt of external payload data provided to said system or for manipulation of the payload data; a plurality of resource module links, one link connecting each resource module to the control module and each resource module. The control module comprises a switch for switching payload data between the plurality of resource modules; and a bandwidth allocator comprising a bandwidth selector and a distributor each connected to the switch and to the resource module links. The bandwidth selector allows the selection of the bandwidth of payload data passed from any of the resource modules to the time switch. Similarly, the bandwidth distributor allows for the selection of the bandwidth of payload data switched through the switch and provided to any of the resource modules from the control module.

Abstract: The invention comprises a method for treatment of chronic and referred pain such as chronic headaches and migraine headaches, as well as pain of the upper back, neck and shoulders, and lower back pain using low power laser light. The source of such referred pain involves microscopic and macroscopic tears in the periosteal-osseous junctions of the upper vertebrae, the scapula, and the skull. These lesions stimulate the generation of histamines, kinins, bradykinins, prostaglandin, proteolytic enzymes, seratonin, and other substances which cause numerous localized autonomic reactions, such as muscle spasm, ischemia, local inflammation, edema, as well as generalized reactions such as increased blood pressure, photophobia, nausea, blurred vision, copious mucous flow of the nose and sinus, and the like. The muscle spasms are responsible for transmitting the pain sensation to other portions of the body, and the systemic reactions are often associated with migraine-type headaches.