Patents by Inventor Eduard J. C. Vreysen

Eduard J. C. Vreysen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing enantiomerically pure imidazo[4,5,1-JK][1,4]-benzodiazepin-2(1H)-thiones
    Patent number: 5599982
    Abstract: Process for preparing enantiomerically pure imidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-thiones of formula ##STR1## starting from 2,6-dihalo-3-nitrobenzyl derivatives (II) and suitably N-protected 1,2-diaminopropanes (III) ##STR2## Novel enantiomerically pure intermediates of formula (III) and (IV) prepared in the course of the present process.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: February 4, 1997
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Alfons G. M. De Knaep, Luc J. R. Moens, Eduard J. C. Vreysen
  • Intermediates for preparing enantiomerically pure imidazo[4,5,1-JK][1,4]-benzodiazepin-2-(1H)-thiones
    Patent number: 5543570
    Abstract: Process for preparing enantiomerically pure imidazo[4,5,1 -jk][1,4]benzodiazepin -2(1H)-thiones of formula ##STR1## starting from 2,6-dihalo-3-nitrobenzyl derivatives (II) and suitably N-protected 1,2-diaminopropanes (III) ##STR2## Novel enantiomerically pure intermediates of formula (III) and (IV) are prepared in the course of the present process.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: August 6, 1996
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Alfons G. M. De Knaep, Luc J. R. Moens, Eduard J. C. Vreysen
  • Process for preparing enantiomerically pure imidazo[4,5,1-JK][1,4]-benzodiazepin-2(1H)-thiones
    Patent number: 5463049
    Abstract: Process for preparing enantiomerically pure imidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-thiones of formula ##STR1## starting from 2,6-dihalo-3-nitrobenzyl derivatives (II) and suitably N-protected 1,2-diaminopropanes (III) ##STR2## Novel enantiomerically pure intermediates of formula (III) and (IV) prepared in the course of the present process.
    Type: Grant
    Filed: February 15, 1994
    Date of Patent: October 31, 1995
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Alfons G. M. De Knaep, Luc J. R. Moens, Eduard J. C. Vreysen