Patents by Inventor Eduard Y. Chekmenev

Eduard Y. Chekmenev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11156684
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: October 26, 2021
    Assignees: Duke University, Vanderbilt University, Board of Trustees of Southern Illinois University
    Inventors: Warren S. Warren, Thomas Theis, Eduard Y. Chekmenev, Milton L. Truong, Aaron M. Coffey, Boyd Goodson, Fan Shi, Roman V. Shchepin
  • Publication number: 20210290781
    Abstract: A RASER-inducing contrast agent for magnetic resonance (MR) modalities that includes a parahydrogen addition to unsaturated molecular precursor that renders radio amplification by stimulated emission of radiation (RASER) of protons and other nuclear spins.
    Type: Application
    Filed: March 16, 2021
    Publication date: September 23, 2021
    Inventors: Eduard Y. Chekmenev, Baptiste Joalland, Nuwandi M. Ariyasingha
  • Publication number: 20210252493
    Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.
    Type: Application
    Filed: February 17, 2020
    Publication date: August 19, 2021
    Applicants: Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of California
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
  • Patent number: 11016152
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields. The spin polarization is hyperpolarization of isotopically enriched heteronuclei by using a catalyst and parahydrogen to create a complex using iridium and applying magnetic fields in the microtesia range to transfer the spin order from parahydrogen to the complex.
    Type: Grant
    Filed: May 12, 2018
    Date of Patent: May 25, 2021
    Assignees: Vanderbilt University, Duke University, The Board of Trustees of Southern Illinois University
    Inventors: Eduard Y. Chekmenev, Danila A. Barskiy, Roman V. Shchepin, Warren S. Warren, Thomas Theis, Boyd Goodson
  • Publication number: 20200172493
    Abstract: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.
    Type: Application
    Filed: November 27, 2019
    Publication date: June 4, 2020
    Applicants: Board of Trustees of Southern Illinois University, Vanderbilt University
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Bryce E. Kidd, Jamil A. Mashni, Miranda Limbach, Yuqing Hou, Fan Shi
  • Publication number: 20200132788
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields. The spin polarization is hyperpolarization of isotopically enriched heteronuclei by using a catalyst and parahydrogen to create a complex using iridium and applying magnetic fields in the microtesia range to transfer the spin order from parahydrogen to the complex.
    Type: Application
    Filed: May 12, 2018
    Publication date: April 30, 2020
    Inventors: Eduard Y. Chekmenev, Danila A. Barskiy, Roman V. Shchepin, Warren S. Warren, Thomas Theis, Boyd Goodson
  • Patent number: 10338052
    Abstract: Methods of detecting a sulfur-containing compound in a sample are described, for example using NMR-SABRE hyperpolarization of the sulfur-containing compounds in the sample. The methods can comprise, for example, contacting a sample comprising a sulfur-containing compound with parahydrogen and a catalyst to form a mixture. A spin order can be transferred from the parahydrogen to the sulfur-containing compound thereby hyperpolarizing the sulfur-containing compound during a temporary association of the parahydrogen, the sulfur-containing compound, and the catalyst. The methods can further comprise, for example, performing an NMR measurement on the mixture comprising the hyperpolarized sulfur-containing compound to detect the hyperpolarized sulfur-containing compound (e.g., from the hyperpolarized NMR signals. In some examples, the methods described herein can be used for detecting a sulfur-containing contaminant in a fuel.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: July 2, 2019
    Assignee: Vanderbilt University
    Inventors: Eduard Y. Chekmenev, Roman V. Shchepin
  • Patent number: 9790245
    Abstract: Iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. The iridium catalysts can be water-soluble iridium catalysts. Also provided are methods for preparing iridium catalysts, and methods of activating and using iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: October 17, 2017
    Assignees: Vanderbilt University, Board of Trustees of Southern Illinois University
    Inventors: Eduard Y. Chekmenev, Boyd M. Goodson, Roman V. Shchepin, Milton L. Truong, Ping He, Quinn A. Best, Fan Shi, Kirsten A. Groome, Aaron M. Coffey
  • Patent number: 9707550
    Abstract: Heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. Also provided are methods for preparing heterogeneous iridium catalysts, and methods of using heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: July 18, 2017
    Assignees: Vanderbilt University, Board of Trustees of Southern Illinois Univeristy
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Fan Shi, Aaron M. Coffey
  • Publication number: 20170153218
    Abstract: Methods of detecting a sulfur-containing compound in a sample are described, for example using NMR-SABRE hyperpolarization of the sulfur-containing compounds in the sample. The methods can comprise, for example, contacting a sample comprising a sulfur-containing compound with parahydrogen and a catalyst to form a mixture. A spin order can be transferred from the parahydrogen to the sulfur-containing compound thereby hyperpolarizing the sulfur-containing compound during a temporary association of the parahydrogen, the sulfur-containing compound, and the catalyst. The methods can further comprise, for example, performing an NMR measurement on the mixture comprising the hyperpolarized sulfur-containing compound to detect the hyperpolarized sulfur-containing compound (e.g., from the hyperpolarized NMR signals. In some examples, the methods described herein can be used for detecting a sulfur-containing contaminant in a fuel.
    Type: Application
    Filed: November 29, 2016
    Publication date: June 1, 2017
    Inventors: Eduard Y. Chekmenev, Roman V. Shchepin
  • Publication number: 20160274043
    Abstract: A method of preparing a hydrogen-containing 13C compound test sample exhibiting an enhanced 13C nuclear magnetic resonance (NMR) signal when exposed to a 13C NMR pulse sequence is disclosed. In the disclosed method, the hydrogen-containing 13C compound is mixed with hyperpolarized 129Xe in the gaseous state, and the mixture is subsequently frozen within a magnetic field. The magnetic field strength is then reduced sufficiently so that spin polarization is transferred from the hyperpolarized 129Xe to the compound. The magnetic field strength is then increased, and the mixture is thawed to obtain the test sample.
    Type: Application
    Filed: March 17, 2016
    Publication date: September 22, 2016
    Inventors: Natalia V. Lisitza, Eduard Y. Chekmenev, Samuel Patz
  • Publication number: 20160169998
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields.
    Type: Application
    Filed: October 28, 2015
    Publication date: June 16, 2016
    Inventors: Warren S. Warren, Thomas Theis, Eduard Y. Chekmenev, Milton Y. Truong, Aaron M. Coffey, Boyd Goodson, Fan Shi, Roman V. Shchepin
  • Patent number: 9289518
    Abstract: A method of preparing a hydrogen-containing 13C compound test sample exhibiting an enhanced 13C nuclear magnetic resonance (NMR) signal when exposed to a 13C NMR pulse sequence is disclosed. In the disclosed method, the hydrogen-containing 13C compound is mixed with hyperpolarized 129Xe in the gaseous state, and the mixture is subsequently frozen within a magnetic field. The magnetic field strength is then reduced sufficiently so that spin polarization is transferred from the hyperpolarized 129Xe to the compound. The magnetic field strength is then increased, and the mixture is thawed to obtain the test sample.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: March 22, 2016
    Assignee: The Brigham and Women's Hospital
    Inventors: Natalia V. Lisitza, Eduard Y. Chekmenev, Samuel Patz
  • Publication number: 20160045907
    Abstract: Iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. The iridium catalysts can be water-soluble iridium catalysts. Also provided are methods for preparing iridium catalysts, and methods of activating and using iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.
    Type: Application
    Filed: July 16, 2015
    Publication date: February 18, 2016
    Inventors: Eduard Y. Chekmenev, Boyd M. Goodson, Roman V. Shchepin, Milton L. Truong, Ping He, Quinn A. Best, Fan Shi, Kirsten A. Groome, Aaron M. Coffey
  • Publication number: 20160016159
    Abstract: Heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. Also provided are methods for preparing heterogeneous iridium catalysts, and methods of using heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.
    Type: Application
    Filed: July 16, 2015
    Publication date: January 21, 2016
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Fan Shi, Aaron M. Coffey
  • Publication number: 20120225020
    Abstract: This disclosure provides choline analogs comprising the following structure: where each R1 independently is H or isotopically enriched D, R2 is a protecting group, and N is 14N or isotopically enriched 15N. This disclosure also provides methods of making choline analogs, which include performing a protection step on a betaine aldehyde to form a choline analog, and methods of using choline analogs to form hyperpolarized compounds.
    Type: Application
    Filed: February 24, 2012
    Publication date: September 6, 2012
    Inventors: Eduard Y. Chekmenev, Roman V. Shchepin
  • Patent number: 7754438
    Abstract: Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: July 13, 2010
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Timothy Cross, William W. Brey, Alexej Smirnov, Eduard Y. Chekmenev
  • Publication number: 20100158810
    Abstract: A method of preparing a hydrogen-containing 13C compound test sample exhibiting an enhanced 13C nuclear magnetic resonance (NMR) signal when exposed to a 13C NMR pulse sequence is disclosed. In the disclosed method, the hydrogen-containing 13C compound is mixed with hyperpolarized 129Xe in the gaseous state, and the mixture is subsequently frozen within a magnetic field. The magnetic field strength is then reduced sufficiently so that spin polarization is transferred from the hyperpolarized 129Xe to the compound. The magnetic field strength is then increased, and the mixture is thawed to obtain the test sample.
    Type: Application
    Filed: August 21, 2009
    Publication date: June 24, 2010
    Inventors: Natalia V. Lisitza, Eduard Y. Chekmenev, Samuel Patz
  • Patent number: 7678546
    Abstract: Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: March 16, 2010
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Timothy Cross, William W. Brey, Alexej Smirnov, Eduard Y Chekmenev
  • Patent number: 7674595
    Abstract: Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: March 9, 2010
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Timothy A. Cross, William W. Brey, Alexej Smirnov, Eduard Y. Chekmenev