Patents by Inventor Eduardo Alexandre Barros e Silva

Eduardo Alexandre Barros e Silva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REFILLABLE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF
    Publication number: 20220401562
    Abstract: The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.
    Type: Application
    Filed: January 6, 2022
    Publication date: December 22, 2022
    Inventors: Yevgeny Brudno, Cathal J. Kearney, Eduardo Alexandre Barros E Silva, Michael Aizenberg, Brian Kwee, Rajiv Desai, Neel Satish Joshi, David J. Mooney
  • ENHANCEMENT OF SKELETAL MUSCLE STEM CELL ENGRAFTMENT BY DUAL DELIVERY OF VEGF AND IGF-1
    Publication number: 20220265779
    Abstract: An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors such as VEGF and IGF; and (c) a population of myogenic cells. Implantation of the device leads to muscle regeneration and repair over an extended period of time.
    Type: Application
    Filed: February 8, 2022
    Publication date: August 25, 2022
    Inventors: David J. Mooney, Cristina Borselli, Herman H. Vandenburgh, Eduardo Alexandre Barros E Silva, Lin Wang, Dimitry Shvartsman, Hannah Storrie, Jeff Lichtman
  • Scaffolds for cell transplantation
    Patent number: 11096997
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: August 24, 2021
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, Jr., Tanyarut Boontheekul
  • REFILLABLE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF
    Publication number: 20200197526
    Abstract: The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.
    Type: Application
    Filed: December 6, 2019
    Publication date: June 25, 2020
    Inventors: Yevgeny Brudno, Cathal J. Kearney, Eduardo Alexandre Barros E Silva, Michael Aizenberg, Brian Kwee, Rajiv Desai, Neel Satish Joshi, David J. Mooney
  • PROGRAMMING OF CELLS FOR TOLEROGENIC THERAPIES
    Publication number: 20190183992
    Abstract: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.
    Type: Application
    Filed: September 5, 2018
    Publication date: June 20, 2019
    Inventors: Roger Warren Sands, Eduardo Alexandre Barros E Silva, Toshihisa Kawai, David J. Mooney
  • SCAFFOLDS FOR CELL TRANSPLANTATION
    Publication number: 20190125849
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: October 25, 2018
    Publication date: May 2, 2019
    Applicants: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • Scaffolds for cell transplantation
    Patent number: 10149897
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: December 11, 2018
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, Jr., Tanyarut Boontheekul
  • Scaffolds for cell transplantation
    Patent number: 10137184
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: November 27, 2018
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, Jr., Tanyarut Boontheekul
  • Programming of cells for tolerogenic therapies
    Patent number: 10080789
    Abstract: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: September 25, 2018
    Assignees: President and Fellows of Harvard College, Forsyth Dental Infirmary for Children
    Inventors: Roger Warren Sands, Eduardo Alexandre Barros E Silva, Toshihisa Kawai, David J. Mooney
  • Programming of Cells for Tolerogenic Therapies
    Publication number: 20160317630
    Abstract: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.
    Type: Application
    Filed: May 5, 2016
    Publication date: November 3, 2016
    Inventors: Roger Warren Sands, Eduardo Alexandre Barros E Silva, Toshihisa Kawai, David J. Mooney
  • Scaffolds For Cell Transplantation
    Publication number: 20160279220
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: April 21, 2016
    Publication date: September 29, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • Scaffolds For Cell Transplantation
    Publication number: 20160279219
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: April 21, 2016
    Publication date: September 29, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • SCAFFOLDS FOR CELL TRANSPLANTATION
    Publication number: 20160271298
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: March 30, 2016
    Publication date: September 22, 2016
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • Scaffolds for cell transplantation
    Patent number: 9446107
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: September 20, 2016
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, Jr., Tanyarut Boontheekul
  • Programming of cells for tolerogenic therapies
    Patent number: 9381235
    Abstract: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: July 5, 2016
    Assignees: President and Fellows of Harvard College, Forsyth Dental Infirmary for Children
    Inventors: Roger Warren Sands, Eduardo Alexandre Barros e Silva, Toshihisa Kawai, David J. Mooney
  • Scaffolds For Cell Transplantation
    Publication number: 20150366956
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: June 25, 2015
    Publication date: December 24, 2015
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • Scaffolds for cell transplantation
    Patent number: 9132210
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: September 15, 2015
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, Jr., Tanyarut Boontheekul
  • Scaffolds For Cell Transplantation
    Publication number: 20150024026
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Application
    Filed: March 24, 2014
    Publication date: January 22, 2015
    Applicants: REGENTS OF THE UNIVERSITY OF MICHIGAN, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: David J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros E Silva, Hyun Joon Kong, Elliot Earl Hill, JR., Tanyarut Boontheekul
  • Scaffolds for cell transplantation
    Patent number: 8932583
    Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: January 13, 2015
    Assignees: President and Fellows of Harvard College, Regents of the University of Michigan
    Inventors: David J. Mooney, Eduardo Alexandre Barros e Silva, Elliot Earl Hill, Jr.
  • PROGRAMMING OF CELLS FOR TOLEROGENIC THERAPIES
    Publication number: 20140234423
    Abstract: Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.
    Type: Application
    Filed: February 20, 2014
    Publication date: August 21, 2014
    Applicants: FORSYTH DENTAL INFIRMARY FOR CHILDREN, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Roger Warren Sands, Eduardo Alexandre Barros e Silva, Toshihisa Kawai, David J. Mooney