Abstract: Microfluidic device having a plurality of microfluidic channels and corresponding dielectrophoresis (DEP) electrode arrays, each channel arranged to direct fluid over a DEP electrode array such that in use target particles are manipulated by the DEP electrode array. The device also has a first connection point and second connection point for connecting the device to an alternating current source, a first input of each DEP electrode array connected to the first connection point via the first conductor and second input of each DEP electrode array connected to the second connection point via the second conductor. A resistance of the first conductor between the first input of each electrode and the first connection point, and a resistance of the second conductor between the second input of each electrode and the second connection point is substantially at least an order of magnitude less than a total resistance of the connected electrode arrays.

Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.

Abstract: A microfluidics device has one or more bubble diversion regions. Problems associated with the generation of air bubbles are avoided in a microfluidics device such as a cartridge, for use with a point of care (POC) diagnostics device, the cartridge being able to carry out downstream processing such as polymerase chain reaction (PCR) and/or nucleic acid capture. The bubble diversion region has a lower flow resistance than the flow resistance of an area of interest.

Abstract: Microfluidic device having a plurality of microfluidic channels and corresponding dielectrophoresis (DEP) electrode arrays, each channel arranged to direct fluid over a DEP electrode array such that in use target particles are manipulated by the DEP electrode array. The device also has a first connection point and second connection point for connecting the device to an alternating current source, a first input of each DEP electrode array connected to the first connection point via the first conductor and second input of each DEP electrode array connected to the second connection point via the second conductor. A resistance of the first conductor between the first input of each electrode and the first connection point, and a resistance of the second conductor between the second input of each electrode and the second connection point is substantially at least an order of magnitude less than a total resistance of the connected electrode arrays.

Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.

Abstract: A microfluidics device has one or more bubble diversion regions. Problems associated with the generation of air bubbles are avoided in a microfluidics device such as a cartridge, for use with a point of care (POC) diagnostics device, the cartridge being able to carry out downstream processing such as polymerase chain reaction (PCR) and/or nucleic acid capture. The bubble diversion region has a lower flow resistance than the flow resistance of an area of interest.

Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.

Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.

Abstract: An inspection sensor module for an in-line pipe inspection tool has a support for mounting the module on the tool, a finger pivotally attached at one end to the support and pivotally attached at the other end to a sensor block carrying one or more inspection sensors. A first leaf spring extends from the support to the finger to bias the finger outwardly, and a second leaf spring extends from the support to the carrier to bias the sensor block. Biasing sensors are mounted on the leading and trailing edges of the first leaf spring to detect movement of the first leaf spring corresponding to movement of the inspection sensors towards or away from the support.

Abstract: An inspection sensor module for an in-line pipe inspection tool has a support for mounting the module on the tool, a finger pivotally attached at one end to the support and pivotally attached at the other end to a sensor block carrying one or more inspection sensors. A first leaf spring extends from the support to the finger to bias the finger outwardly, and a second leaf spring extends from the support to the carrier to bias the sensor block. Biasing sensors are mounted on the leading and trailing edges of the first leaf spring to detect movement of the first leaf spring corresponding to movement of the inspection sensors towards or away from the support.