Abstract: This invention is related to the field of cancer treatment, more specifically to gene therapy in combination with a suitable chemotherapeutic agent. The present invention is related to a new oncolytic virus, which is able to inhibit the growth of malignant tumors or is a treatment of hyperproliferative mammalian cells, or is a treatment of cancer. The oncolytic virus works in combination with a suitable chemotherapeutic agent. More specifically, the present invention provides a pharmaceutical kit comprising an oncolytic adenovirus and a chemotherapeutic agent, and a method for the treatment of cancer.

Abstract: The present invention features, inter alia, nucleic acid constructs that include nucleotide sequences for regulating the expression of a sequence of interest. The sequences in the construct are not naturally associated with one another (i.e., they are heterologous), and they include an enhancer comprising response elements (e.g. Tcf sites) and nucleosome positioning regions. The enhancer can be operably linked to a promoter (e.g., a human REG1A-571 promoter) that drives the expression of a sequence of interest. Also included are vectors comprising these constructs, host cells, kits, pharmaceutical formulations, and methods of treating patients with cancer.

Abstract: This invention is related to the field of cancer treatment, more specifically to gene therapy in combination with a suitable chemotherapeutic agent. The present invention is related to a new oncolytic virus, which is able to inhibit the growth of malignant tumors or is a treatment of hyperproliferative mammalian cells, or is a treatment of cancer. The oncolytic virus works in combination with a suitable chemotherapeutic agent. More specifically, the present invention provides a pharmaceutical kit comprising an oncolytic adenovirus and a chemotherapeutic agent, and a method for the treatment of cancer.

Abstract: This invention describes antineoplastic compound derived from Deschampsia antarctica plants. The biologically active compounds are further characterized. The described compounds are demonstrated to have a capacity to inhibit cancer cell proliferation.

Abstract: The present disclosure provides a novel antineoplastic extract obtained from Deschampsia antarctica plant. Active components of the antineoplastic extract are also disclosed and a method to prevent proliferation of cancerous or tumorous cells with the extract or with components thereof is disclosed. Furthermore, a method to induce production of active ingredients in in vitro grown plants by submitting the plants to physical or chemical treatements before preparing the antineoplastic extract is disclosed. This disclosure provides compostions of tablets and pellets for treating patients with cancer or for prevention of occurence of cancerous diseases.