Abstract: The present invention provides intravascular diagnostic catheters that include one or more wall-contacting/wall-approaching probes including IVUS probe elements and diagnostic systems including such catheters, for the evaluation and diagnosis of blood vessels. Also provided are intravascular catheters in which the wall-contacting/wall-approaching probes further include an optical probe element and systems including such catheters, for combined IVUS and optical analysis of a blood vessel wall.

Abstract: Apparatus and methods are provided for measuring axial displacement of an imaging catheter, and for using real-time images acquired by the imaging catheter to measure axial lengths of anatomical sites. The apparatus of the present invention includes a catheter having an imaging element disposed on a distal portion and indicia disposed on a proximal portion. The length of the catheter permits the indicia to be disposed at least partially external to a patient and visible to a medical practitioner when the imaging element is disposed within the blood vessel. Accordingly, the medical practitioner can observe the indicia and associate axial locations of the catheter indicated by the indicia with images obtained by the imaging element.

Abstract: A method to measure spatial fluid flow components and their velocity profiles in a number of locations in a cross-sectional area of a lumen or other body cavity by using ultrasound in which the cross-sectional area is interrogated by a plurality of ultrasonic beams; the estimation of the spatial flow components is obtained from a combination of estimations of axial, lateral and total flow; the estimation of one or more flow components is obtained through any combination of time-shift and decorrelation analysis of two or more beam-signals of the interrogating ultrasound transducer; and the estimation accuracy is further improved by the use of a reference decorrelation curve obtained from experiments or beam-theory or both.

Abstract: The present invention provides methods and apparatus for identifying and stabilizing vulnerable plaque via multi-functional catheters having both infrared detection and imaging capabilities. It is expected that correlating imaging and infrared data will facilitate improved identification of vulnerable plaque. Apparatus of the present invention may also be provided with optional stabilization elements for stabilizing vulnerable plaque, as well as optional embolic protection. Methods of using apparatus of the present invention are also provided.

Abstract: The present invention provides methods and apparatus for identifying and stabilizing vulnerable plaque via multi-functional catheters having both thermography and imaging capabilities. It is expected that correlating imaging and thermography data will facilitate improved identification of vulnerable plaque. Apparatus of the present invention may also be provided with optional stabilization elements for stabilizing vulnerable plaque, as well as optional embolic protection. Methods of using apparatus of the present invention are provided.

Abstract: The present invention provides methods and apparatus for identifying and stabilizing vulnerable plaque via multi-functional catheters having both thermography and imaging capabilities. It is expected that correlating imaging and thermography data will facilitate improved identification of vulnerable plaque. Apparatus of the present invention may also be provided with optional stabilization elements for stabilizing vulnerable plaque. Methods of using apparatus of the present invention are provided.

Abstract: The present invention provides methods and apparatus for identifying and stabilizing vulnerable plaque via multi-functional catheters having both thermography and imaging capabilities. It is expected that correlating imaging and thermography data will facilitate improved identification of vulnerable plaque. Apparatus of the present invention may also be provided with optional stabilization elements for stabilizing vulnerable plaque, as well as optional embolic protection. Methods of using apparatus of the present invention are provided.

Abstract: A method to measure spatial fluid flow components and their velocity profiles in a number of locations in a cross-sectional area of a lumen or other body cavity by using ultrasound in which the cross-sectional area is interrogated by a plurality of ultrasonic beams; the estimation of the spatial flow components is obtained from a combination of estimations of axial, lateral and total flow; the estimation of one or more flow components is obtained through any combination of time-shift and decorrelation analysis of two or more beam-signals of the interrogating ultrasound transducer; and the estimation accuracy is further improved by the use of a reference decorrelation curve obtained from experiments or beam-theory or both.

Abstract: A method to measure spatial fluid flow components and their velocity profiles in a number of locations in a cross-sectional area of a lumen or other body cavity by using ultrasound in which the cross-sectional area is interrogated by a plurality of ultrasonic beams; the estimation of the spatial flow components is obtained from a combination of estimations of axial, lateral and total flow; the estimation of one or more flow components is obtained through any combination of time-shift and decorrelation analysis of two or more beam-signals of the interrogating ultrasound transducer, and the estimation accuracy is further improved by the use of a reference decorrelation curve.