Patents by Inventor Eduardo M. Sotomayor

Eduardo M. Sotomayor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective histone deactylase 6 inhibitors
    Patent number: 9409858
    Abstract: Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula (I). Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: August 9, 2016
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., Board of Trustees of the University of Illinois
    Inventors: Eduardo M. Sotomayor, Joel Bergman, Alan Kozikowski, Karrune Veeraprasert Woan, Alejandro V. Villagra
  • SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS
    Publication number: 20160185716
    Abstract: Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula I. Specifically, the disclosed subject matter relates to compounds having activity as selective HDAC6 inhibitors, methods of making and using the compounds, and compositions comprising the compounds. In still further aspects, the disclosed subject matter relates to methods for treating oncological disorders in a patient. Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.
    Type: Application
    Filed: July 30, 2014
    Publication date: June 30, 2016
    Inventors: Eduardo M. Sotomayor, Joel A. Bergman, Alan P. Kozikowski, Alejandro V. Lagra, Karrune V. Woan
  • HDAC INHIBITORS, ALONE OR IN COMBINATION WITH BTK INHIBITORS, FOR TREATING NONHODGKIN'S LYMPHOMA
    Publication number: 20150105409
    Abstract: The invention relates to HDAC inhibitors, or combinations comprising an HDAC inhibitor and a BTK inhibitor for the treatment of non-hodgkin's lymphoma in a subject in need thereof. Also provided herein are methods for treating non-hodgkin's lymphoma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an HDAC inhibitor, or a combination comprising an HDAC inhibitor and a BTK inhibitor.
    Type: Application
    Filed: October 7, 2014
    Publication date: April 16, 2015
    Applicant: Acetylon Pharmaceticals, Inc.
    Inventors: Steven Norman Quayle, Simon Stewart Jones, Eduardo M. Sotomayor, Javier Pinilla-Ibarz, Eva Sahakian
  • SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS
    Publication number: 20150056213
    Abstract: Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula (I). Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.
    Type: Application
    Filed: March 7, 2013
    Publication date: February 26, 2015
    Inventors: Eduardo M. Sotomayor, Joel Bergman, Alan Kozikowski, Karrune Veeraprasert Woan, Alejandro V. Villagra
  • Flagellin-based adjuvants and vaccines
    Patent number: 7404963
    Abstract: The present invention provides adjuvants, vaccines and related methods that are useful in eliciting immune responses, particularly immune responses against tumor antigens. We discovered that flagellin is capable of inhibiting tolerance when it is administered in conjunction with a tolerogenic antigen. This effect is likely mediated by the ability of flagellin to induce IL-12 while keeping IL-10 levels low. Furthermore, flagellin can be provided in an extended-releasing manner by using a flagellin-expressing cell. Preferably, the flagellin-expressing cell is treated such that it is no longer capable of replicating, yet retaining the ability to express flagellin, such as by lethal irradiation.
    Type: Grant
    Filed: October 3, 2005
    Date of Patent: July 29, 2008
    Assignee: The University of South Florida
    Inventors: Eduardo M. Sotomayor, Ildefonso Suarez