Patents by Inventor Eduardo Martínez Díaz

Eduardo Martínez Díaz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11510965
    Abstract: The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: November 29, 2022
    Assignee: Centro de Ingeniería Genética y Biotecnología
    Inventors: Héctor Jesús Santana Milian, Leonor Ventosa Rull, Eduardo Martínez Díaz, Jorge Amador Berlanga Acosta, Ingrid Cabrera Puig, Jaume Veciana Miró
  • Patent number: 10213379
    Abstract: Pharmaceutical formulations in suppository form, containing thrombolytic agents, which are able to penetrate rectal mucous, for the treatment of acute hemorrhoid diseases and/or diseases of thrombotic origin.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: February 26, 2019
    Assignee: CENTRO DE INGENIERIA GENETICA Y BIOTECHNOLOGIA
    Inventors: Maria Acelia Marrero Miragaya, Ana Aguilera Barreto, Lisette Gonzalez Chavez, Eduardo Martinez Diaz, Beatriz Torrez Cabrera, Karelia Cosme Diaz, Luciano Francisco Hernandez Marrero, Beatriz Tamargo Santos
  • Publication number: 20180015145
    Abstract: The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.
    Type: Application
    Filed: July 31, 2017
    Publication date: January 18, 2018
    Inventors: Héctor Jesús Santana Milián, Leonor Ventosa Rull, Eduardo Martínez Díaz, Jorge Amador Berlanga Acosta, Ingrid Cabrera Puig, Jaume Veciana Miró
  • Patent number: 9717776
    Abstract: The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: August 1, 2017
    Assignees: CENTRO DE INGENIERÍA GENÉTICA Y BIOTECNOLOGÍA, CONSEJO SUPERIOR DE INVESTIGACIONES CENTÍFICAS
    Inventors: Héctor Jesús Santana Milián, Leonor Ventosa Rull, Eduardo Martínez Díaz, Jorge Amador Berlanga Acosta, Ingrid Cabrera Puig, Jaume Veciana Miró
  • Patent number: 9375459
    Abstract: The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: June 28, 2016
    Assignee: CENTRO DE INGENIERIA GENETICA BIOTECNOLGIA
    Inventors: María del Carmen Abrahantes Pérez, Glay Chinea Santiago, Eduardo Martínez Diaz, Hilda Elisa Garay Pérez, Osvaldo Reyes Acosta, Ernesto Lopez Mola, Cruz Matilde Lopez Abad, Sonia Gonzalez Blanco
  • Patent number: 9205130
    Abstract: The present invention comprises a pellet of epidermal growth factor and methionine or K2S2O7, a capsule which comprises these pellets, processes for theirs preparations and it use for the treatment of ulcerative colitis.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: December 8, 2015
    Assignees: CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA, BIOREC S.A.
    Inventors: Raimundo Ubieta Gómez, Ana Aguilera Barreto, Eduardo Martínez Díaz, Rolando Paez Meireles, Antonio Sereno Guerra
  • Publication number: 20150182590
    Abstract: The invention relates to vesicles comprising Epidermal Growth Factor (EGF), a cationic surfactant and cholesterol or derivatives thereof. The invention also discloses a procedure for their preparation, based on compressed fluid technology (CFs). The vesicles of the invention are useful in the manufacture of drugs and cosmetics and in tissue engineering.
    Type: Application
    Filed: August 2, 2013
    Publication date: July 2, 2015
    Inventors: Héctor Jesús Santana Milián, Leonor Ventosa Rull, Eduardo Martínez Díaz, Jorge Amador Berlanga Acosta, Ingrid Cabrera Puig, Jaume Veciana Miró
  • Publication number: 20140112976
    Abstract: The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems.
    Type: Application
    Filed: March 21, 2012
    Publication date: April 24, 2014
    Applicant: CENTRO DE INGENIERIA GENETICA BIOTECNOLOGIA
    Inventors: María del Carmen Abrahantes Pérez, Glay Chinea Santiago, Eduardo Martínez Díaz, Hilda Elisa Garay Perez, Osvaldo Reyes Acosta, Ernesto Lopez Mola, Cruz Matilde Lopez Abad, Sonia Gonzalez Blanco
  • Publication number: 20120308661
    Abstract: The present invention comprises a pellet of epidermal growth factor and methionine or K2S2O7, a capsule which comprises these pellets, processes for theirs preparations and it use for the treatment of ulcerative colitis.
    Type: Application
    Filed: February 10, 2011
    Publication date: December 6, 2012
    Applicants: BIOREC S. A., CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
    Inventors: Raimundo Ubieta Gómez, Ana Aguilera Barreto, Eduardo Martínez Díaz, Rolando Paez Meireles, Antonio Sereno Guerra
  • Patent number: 8076297
    Abstract: The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1-100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's “in vivo” administration has antitumoral, antiangiogenic and protective effect against malignant tumors.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: December 13, 2011
    Assignee: Centro De Ingenieria Genetica Y Biotecnologia
    Inventors: Maria del Carmen Abrahantes Pérez, Jesús Reyes González, Gloria Véliz Rios, Eduardo Martinez Diaz, Caridad Anais Gasmuri González, José Garcia Suárez, Mónica Bequet Romero, Luis Javier González López, Lila Rosa Castellanos Serra, Manuel Selman-Housein Sosa, Raúl Gómez Riera, Jorge Victor Gavilondo Cowley
  • Publication number: 20110218138
    Abstract: The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1-100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's “in vivo” administration has antitumoral, antiangiogenic and protective effect against malignant tumors.
    Type: Application
    Filed: July 5, 2005
    Publication date: September 8, 2011
    Inventors: María Del Carmen Abrahantes Pérez, Jesús Reyes González, Gloria Véliz Rios, Eduardo Martínez Díaz, Caridad Anais Gasmuri González, José Garcia Suárez, Mónica Bequet Romero, Luis Javier González López, Lisa Rosa Castellanos Serra, Manuel Selman-Housein Sosa, Raúl Gómez Riera, Jorge Victor Gavilondo Cowley