Patents by Inventor Edurne SAN JOSÉ ENÉRIZ

Edurne SAN JOSÉ ENÉRIZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10407423
    Abstract: It relates to the compounds of formula (I), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein A, R1, R2, and R3 are as defined herein, which are inhibitors of one or more DNMTs selected from the group consisting of DNMT1, DNMT3A and DNMT3B. It also relates to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer, fibrosis and/or immunomodulation.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: September 10, 2019
    Assignee: FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA
    Inventors: Xabier Aguirre Ena, Julen Oyarzabal Santamarina, Felipe Prósper Cardoso, Maria Obdulia Rabal Gracia, Edurne San José Enériz, Juan Antonio Sánchez Arias
  • Publication number: 20190127354
    Abstract: It relates to the compounds of formula (I), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures of stereoisomers, wherein R is a radical selected from the group consisting of formula (A), formula (B), formula (C), formula (D), and formula (E), and R1, R2, and R3 are as defined herein, which are inhibitors of one or more DNMTs selected from the group consisting of DNMT1, DNMT3A and DNMT3B. It also relates to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer, fibrosis and/or immunomodulation.
    Type: Application
    Filed: December 13, 2016
    Publication date: May 2, 2019
    Inventors: Xabier AGUIRRE ENA, Julen OYARZABAL SANTAMARINA, Felipe PRÓSPER CARDOSO, Maria Obdulia RABAL GRACIA, Edurne SAN JOSÉ ENÉRIZ, Juan Antonio SÁNCHEZ ARIAS
  • Publication number: 20180362525
    Abstract: It relates to the compounds of formula (I), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein A, R1, R2, and R3 are as defined herein, which are inhibitors of one or more DNMTs selected from the group consisting of DNMT1, DNMT3A and DNMT3B. It also relates to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer, fibrosis and/or immunomodulation.
    Type: Application
    Filed: November 15, 2016
    Publication date: December 20, 2018
    Inventors: Xabier AGUIRRE ENA, Julen OYARZABAL SANTAMARINA, Felipe PRÓSPER CARDOSO, Maria Obdulia RABAL GRACIA, Edurne SAN JOSÉ ENÉRIZ, Juan Antonio SÁNCHEZ ARIAS
  • Patent number: 9840500
    Abstract: It relates to the use of compounds of formula (I?), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, as anticancer agents and as agents for generating induced pluripotent stem cells. Compounds of formula (I?), wherein R2? is an alcoxy group, a hydrocarbon chain or a ring system, and R1, R3, and R4 are as defined herein, are dual inhibitors of histone methyltransferases and DNA methyltransferases. It also relates to the compounds of formula (I?), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein R2? is phenyl or 5- to 6-membered heteroaromatic ring, both optionally fused to another rings (i.e., compounds of formula (I)). It also relates to pharmaceutical or veterinary compositions containing compounds of formula (I).
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: December 12, 2017
    Assignee: FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA
    Inventors: Xabier Aguirre Ena, Julen Oyarzabal Santamarina, Felipe Prósper Cardoso, Maria Obdulia Rabal Gracia, Juan Roberto Rodríguez Madoz, Edurne San José Enériz
  • Publication number: 20170121316
    Abstract: It relates to the use of compounds of formula (I?), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, as anticancer agents and as agents for generating induced pluripotent stem cells. Compounds of formula (I?), wherein R2? is an alcoxy group, a hydrocarbon chain or a ring system, and R1, R3, and R4 are as defined herein, are dual inhibitors of histone methyltransferases and DNA methyltransferases. It also relates to the compounds of formula (I?), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures thereof, wherein R2? is phenyl or 5- to 6-membered heteroaromatic ring, both optionally fused to another rings (i.e., compounds of formula (I)). It also relates to pharmaceutical or veterinary compositions containing compounds of formula (I).
    Type: Application
    Filed: March 30, 2015
    Publication date: May 4, 2017
    Inventors: Xabier AGUIRRE ENA, Julen OYARZABAL SANTAMARINA, Felipe PRÓSPER CARDOSO, Maria Obdulia RABAL GRACIA, Juan Roberto RODRÍGUEZ MADOZ, Edurne SAN JOSÉ ENÉRIZ