Abstract: An example method includes receiving, by one or more processing circuits, a registration request comprising an identifier and an activation gesture associated with a mobile application on a mobile device. The example method includes sending, by the one or more processing circuits to the mobile application on the mobile device, a notification indicating the mobile device is registered. The example method includes receiving, by the one or more processing circuits, a content item test request for content items in a specific content network. The example method includes testing, by the one or more processing circuits, the content items on the specific content network. The example method includes transmitting, by the one or more processing circuits to the mobile application on the mobile device, content event logs comprising debugging information of the content items during the testing on the content network.

Abstract: Compounds for the delivery of progranulin, a progranulin fragment, and/or at least one granulin protein subunit across the blood brain barrier. Compounds for the delivery of progranulin, a progranulin fragment, and/or at least one granulin protein subunit across the blood brain barrier, the compounds including a progranulin domain, a TfR1 binding domain, and optionally an albumin binding domain. Compounds for the delivery of wildtype or unmodified progranulin across the blood brain barrier.

Abstract: A fuel supply arrangement (1) for a fuel monitoring system (3). It comprises a fuel distribution arrangement (31) and a fuel monitoring outlet line (29) which, in use, is connected to a source of fuel (7). The fuel distribution arrangement (31) comprises a fuel monitoring supply line (57), to which is connected an inline fuel pump (53). A first fuel sensor supply circuit (67) and a second fuel sensor supply circuit (71) are each connected to the fuel monitoring supply circuit (57) downstream of the inline fuel pump (53). The first fuel sensor supply circuit (67) is provided with a sensor inlet connection and a sensor outlet connection for inline connection of a sensor. The second fuel sensor supply circuit (71) comprises a sensor manifold (91) with ports for connection of a plurality of sensors (97,99) in series with each other.

Abstract: A power transistor circuit suppling an internal voltage to an internal voltage supply node. The power transistor circuit includes external terminals, to each of which signals and/or voltages are applied, for each of the input node, output node and control node of the power transistor. The power transistor circuit includes the power transistor, a current draw transistor, a first diode connected between an external control terminal and the internal voltage supply node, and a second diode connected between the current draw transistor output node and the internal voltage supply node. The power transistor circuit includes a charge pump that receives power from the internal voltage supply node and outputs a voltage to the control node of the current draw transistor. In operation, the internal voltage supply node receives power from the external control terminal via the first diode, or an external input terminal via the current draw transistor and the second diode.

Abstract: A current sense circuit that allows for accurate sensing of a power current that flows through a power transistor as the power transistor ages. The circuit includes the power transistor, a sense transistor and a pull-up component. The control nodes of the power transistor and the sense transistor are connected, causing the power transistor and sense transistor to be on or off simultaneously. The pull-up component is connected between the input node of the power transistor and the input node of the sense transistor. When power is provided to the pull-up component, and when each of the power transistor and sense transistor are off, the pull-up component forces a voltage present at the sense transistor input node to be approximately equal to a voltage present at the power transistor input node, causing the sense and power transistors to age together.

Abstract: Disclosed are Valve Replacement devices, systems, and methods. Valve replacement devices may comprise One- or Two-Piece systems comprising an Adapter body and a Valve Assembly with leaflets positioned within the Adapter body. In Two-Piece systems, the Valve Assembly may be removable from the Adapter body such that both can be delivered together or separately, and the Adapter body may remain implanted while the Valve Assembly may be removed and replaced (i.e., “ReValved”). Also described are devices (such as a delivery catheter device), systems, and methods related to such delivering and Re Valving the Valve Replacement. Such delivery methods may include transseptal insertion of a new minimum leaflet structure, and securement of the Valve Replacement using several securement type (e.g., supra-annular, sub-annular, radial, leaflet securement, etc.). Also described is a braided helical design that mimics the heart's natural movement, and a flange structure for assisting the functioning of the Valve Replacement.

Abstract: Electronic devices comprising pixels for sensing, methods for operating the electronic devices, and methods for manufacturing the electronic devices are disclosed. In some embodiments, the electronic devices comprise hinges for supporting the pixels. In some embodiments, the electronic devices are configured to provide a bias voltage to the pixels.

Abstract: Membrane fabrication including: depositing a bottom Molybdenum (Mo) layer; depositing a polyimide (PI) layer and defining a first release hole; curing the PI layer; depositing a top Mo layer; and defining and etching a second release hole within the first release hole.

Abstract: Systems, methods and computer-readable storage media can be used to debug content items. One example method includes presenting, by a mobile application executing on a mobile device, a first application interface. The example method further includes detecting, by the mobile device, a predetermined user action. The example method further includes, in response to detecting the predetermined user action, generating debugging information from content event logs, wherein the content event logs are associated with content item slots in which content items are presented in the mobile application and presenting, by a debugging interface, the debugging information.

Abstract: Aspects of the disclosure include fixed dose pharmaceutical compositions including a plurality of immediate release beads of oxybutynin, or pharmaceutically acceptable salt thereof, beads and a plurality of delayed-immediate release beads of pilocarpine, or pharmaceutically acceptable salt thereof and methods for treating hyperhidrosis in a subject. In some embodiments the plurality of beads are encapsulated in a size 3 capsule. In practicing methods according to certain embodiments, a variety of formulations are described to achieve a delayed-immediate release profile wherein the pilocarpine, or pharmaceutically acceptable salt thereof, is released not more than 30% in 10 minutes and not less than 85% at 45 minutes of administration of the pharmaceutical composition to the subject and oxybutynin is released soon after administration.

Abstract: A new type of instruction and a control register for the new type of instruction are provided to handle data that may be misaligned in memory. A first part of data (which may be misaligned in memory) is loaded into a first set of registers by loading a first atom containing the first part of data into registers. The pack instruction is executed by an execution unit to place part of data (whose length and starting position are indicated by second and third values in a control register) from one set of registers into an identified location (identified by a first value in the control register) in another set of registers.

Abstract: Provided is a method for review of an XBRL document. An XBRL document is received followed by a request to create an XBRL review for the XBRL document. A selection of an XBRL fact included in the XBRL document is received and a first review status, of a plurality of review statuses, is applied to the selected XBRL fact. The selected XBRL fact is monitored to detect a change to the XBRL fact, and in response to detecting a change to the XBRL fact, the first review status of the XBRL fact is updated to a second review status of the plurality of review statuses.

Abstract: A method for determining conflicts in updates of a hydrocarbon control system includes obtaining a first configuration and a second configuration from different locations in the hydrocarbon control system. The method also includes comparing the first configuration and the second configuration to determine if differences are detected. If differences are detected, the method includes operating a display to notify a user that differences are detected, using conflict resolution techniques to automatically determine a resolved configuration, and updating a configuration of the hydrocarbon control system with the resolved configuration. If no differences are detected, the method includes operating the display to notify the user that no differences are detected and updating the configuration of the hydrocarbon control system with the first configuration or the second configuration.

Abstract: Microelectromechanical system (MEMS) devices, methods of operating the MEMS device, and methods of manufacturing the MEMS device are disclosed. In some embodiments, the MEMS device includes a glass substrate; an electrode on the glass substrate; a hinge mechanically coupled to the electrode; a membrane mirror mechanically coupled to the hinge; a TFT on the glass substrate and electrically coupled to the electrode; and a control circuit comprising: a multiplexer configured to turn on or turn off the TFT; and a drive source configured to provide a drive signal for charging the electrode through the TFT. An amplitude of the drive signal corresponds to an amount of charge, and the amount of charge generates an electrostatic force for actuating the hinge and a portion of the membrane mirror mechanically coupled to the hinge.

Abstract: A battery pack includes a cassette stack comprising a plurality of battery cell cassettes, each of the cassettes including a plurality of support structures. Each support structure comprises an electrically and thermally conductive frame for receiving at least one battery cell having a first terminal and a second terminal, and a heat pipe. The first terminal is electrically coupled to the frame when the at least one battery cell is mounted in the frame. The heat pipe provides thermal conductivity between the frame and a cooling surface. A method of cooling an electric vehicle including a battery pack comprises aligning the battery pack and a cooling structure, moving the cooling structure into contact with the electric vehicle, and circulating coolant through the cooling structure.

Abstract: An apparatus and method for manufacturing an elastic composite structure for an absorbent sanitary product includes a bonding unit configured to bond a first web layer to a second web layer via a bond pattern that includes at least one bond line having at least one pair of adjacent bonds. The bonding unit secures an elastic thread within a passage defined by the at least one pair of adjacent bonds. The passage has a cross-sectional area smaller than a cross-sectional area of the elastic thread in a non-tensioned state.

Abstract: A medical gown (100) and method of donning are disclosed herein. The medical gown may comprise a top portion (110), a bottom portion (112), a first tie (134), a second tie (136), and a cover patch (120). The top portion may include arms (140) and a neck opening (152). The bottom portion may include a front bottom side (128), a first rear flap (130), a second rear flap (132), and the first tie integrally formed with the first rear flap. The first and second rear flaps may extend from opposite edges of the front bottom side. The cover patch may be configured to at least partially couple the top portion and the bottom portion together. The second tie may be coupled between the cover patch and the bottom portion. The medical gown may provide easy donning and doffing as well as be optimally configured for manufacturing using automation.

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3?, R4, R5, X1, X2, X3, X4, and n are described herein.

Abstract: A “zero turn radius” batch cart for delivering loads of raw concrete mix over difficult and uneven construction job sites transports a tiltable, load-receptive hopper displaceable between load bearing and load discharging positions. The rigid chassis is supported by front, hydraulically powered drive wheel assemblies and a pair of rear caster wheels for steering effects. An internal combustion engine, with its own throttle control, drives a hydraulic pump that powers separate hydraulic motors and valves for operating the cart. The front-mounted drive wheel assemblies are independently, hydraulically driven and each can be rotated forwardly or rearwardly independently of the other. Quick and precise zero-turn radius steering movements will result when the front wheel assemblies rotate in different directions, in combination with the caster rear wheel assemblies that exhibit negative caster.

Abstract: The present invention relates to binding molecules (e.g. antibodies) for the treatment of cancer, and related antibody-drug conjugates.