Patents by Inventor Edward A. Clark

Edward A. Clark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12018291
    Abstract: The present invention provides compositions of CD 180 targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease.
    Type: Grant
    Filed: December 9, 2022
    Date of Patent: June 25, 2024
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Edward Clark, Jay Wesley Chaplin
  • Patent number: 11964211
    Abstract: Systems, methods, and other embodiments associated with output production are described. One example system comprises an analysis component configured to analyze a data set to produce an evaluation result. The system also comprises a production component configured to produce a rendered output based, at least in part, on the evaluation result, where the rendered output is stored in a computer-readable medium.
    Type: Grant
    Filed: January 10, 2021
    Date of Patent: April 23, 2024
    Inventors: Ronald Charles Krosky, Brendan Edward Clark
  • Publication number: 20240123061
    Abstract: Provided herein are compositions of CD1280 binding proteins and a Hepatitis B virus core antigen (HBcAg) and/or a Hepatitis B virus E antigen (HBeAg), or antigenic fragments or mutants thereof, attached to the CD180 binding protein, and methods for using the compositions to treat or limit the development of hepatitis-B virus (HBV)-related disorders.
    Type: Application
    Filed: December 8, 2023
    Publication date: April 18, 2024
    Inventors: Edward A. CLARK, Deborah L. FULLER, Che-Leung LAW, Amanda MAK
  • Publication number: 20240115810
    Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.
    Type: Application
    Filed: December 14, 2023
    Publication date: April 11, 2024
    Inventors: Michael Schabbach, Anthony Paul Morris, Ronald Antony Smith, Brian Charles Molyneux, Paul Richard Draper, Craig Ashley Mason, Oliver Charles Gazeley, Daniel Edward Clark, David Aubrey Plumptre, Aidan Michael O'Hare, Richard James Thomas, Felix Kramer, Beat Wyss, Philipp Müller
  • Publication number: 20240091108
    Abstract: Pouches are disclosed that can incorporate components in addition to consumables such as nicotine. Such components can include tooth whitening substances, oral antiseptics, gum or tooth health substances, vitamins, medicaments, and others. Such components can be provided within a pouch with the consumable, be impregnated into a pouch material, or be coated onto a pouch.
    Type: Application
    Filed: September 13, 2023
    Publication date: March 21, 2024
    Inventors: Brendan Edward Clark, Ronald Charles Krosky
  • Publication number: 20240092791
    Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
    Type: Application
    Filed: December 13, 2021
    Publication date: March 21, 2024
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Fabio RANCATI, Alessandro ACCETTA, Anna Maria CAPELLI, Daniele PALA, Christine EDWARDS, Adele Elisa PASQUA, Prashant Bhimrao KAPADNIS, Arnaud Jean Francois Auguste CHEGUILLAUME, David Edward CLARK
  • Publication number: 20240092790
    Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
    Type: Application
    Filed: December 13, 2021
    Publication date: March 21, 2024
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Fabio RANCATI, Alessandro ACCETTA, Anna Maria CAPELLI, Daniele PALA, Christine EDWARDS, Adele Elisa PASQUA, Prashant Bhimrao KAPADNIS, Arnaud Jean Francois Auguste CHEGUILLAUME, David Edward CLARK
  • Publication number: 20240059691
    Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in medicine; and methods of treating patients with such compounds; wherein A, W, R5, n, Z, X, Y and B are as defined herein. The present invention also relates to compounds useful as synthetic intermediates of compounds of formula (I).
    Type: Application
    Filed: December 1, 2021
    Publication date: February 22, 2024
    Inventors: Mitchell Lewis CHILDS, Rebecca Louise DAVIE, Hannah Joy EDWARDS, David Michael EVANS, William Jack GREVES, Simon Teanby HODGSON, Alessandro MAZZACANI, Carl Leslie NORTH, Alicja Stela OBARA, Michael Bryan ROE, David Philip ROOKER, Michael John STOCKS, Louise Michelle BIRCH, Mark PICHOWICZ, Rachael PITTAWAY, Alun John SMITH, Adam Eric THROUP, Joseph William WRIGGLESWORTH, Xuezheng YANG, David Edward CLARK
  • Patent number: 11883488
    Abstract: Provided herein are compositions of CD1280 binding proteins and a Hepatitis B virus core antigen (HBcAg) and/or a Hepatitis B virus E antigen (HBeAg), or antigenic fragments or mutants thereof, attached to the CD180 binding protein, and methods for using the compositions to treat or limit the development of hepatitis-B virus (HBV)-related disorders.
    Type: Grant
    Filed: April 15, 2022
    Date of Patent: January 30, 2024
    Assignee: Abacus Bioscience, Inc.
    Inventors: Edward A. Clark, Deborah L. Fuller, Che-Leung Law, Amanda Mak
  • Patent number: 11878150
    Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: January 23, 2024
    Assignee: Sanofi
    Inventors: Michael Schabbach, Anthony Paul Morris, Ronald Antony Smith, Brian Charles Molyneux, Paul Richard Draper, Craig Ashley Mason, Oliver Charles Gazeley, Daniel Edward Clark, David Aubrey Plumptre, Aidan Michael O'Hare, Richard James Thomas, Felix Kramer, Beat Wyss, Philipp Muller
  • Publication number: 20240016941
    Abstract: The invention provides a combinations and pharmaceutical compositions comprising (i) a compound which is an indane according to Formula (I) or a pharmaceutically acceptable salt thereof; and (ii) one or more CFTR modulator; wherein R1, R2, R3, R4, n, Lk, (A), G and m are as defined herein. Also provided are therapeutic uses of such combinations and compositions in the treatment of conditions such as cystic fibrosis.
    Type: Application
    Filed: March 23, 2021
    Publication date: January 18, 2024
    Applicant: Antabio SAS
    Inventors: Martin Everett, Simon Leiris, David Thomas Davies, Nicolas Sprynski, Lilha Beyria, Thomas David Pallin, Andrew Peter Cridland, Toby Jonathan Blench, Richard Leonard Elliott, David Edward Clark
  • Publication number: 20230391211
    Abstract: A charging system for an automated guided vehicle, AGV, is presented. The charging system includes an offboard, meshed charging grid and onboard contact pads. The offboard, meshed charging grid including a charging pole in each grid point, wherein adjacent charging poles are configured with opposite polarity of a charging current. The onboard contact pads include four separate contact pads. An AGV is also presented.
    Type: Application
    Filed: December 29, 2020
    Publication date: December 7, 2023
    Inventors: Haofeng Bai, Panagiotis Bakas, Ahmed Abdelhakim, Rajakrishnan Radjassamy, Edward Clark Fontana
  • Patent number: 11813439
    Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: November 14, 2023
    Assignee: Sanofi
    Inventors: Michael Schabbach, Anthony Paul Morris, Ronald Antony Smith, Brian Charles Molyneux, Paul Richard Draper, Craig Ashley Mason, Oliver Charles Gazeley, Daniel Edward Clark, David Aubrey Plumptre, Aidan Michael O'Hare, Richard James Thomas, Felix Kramer, Beat Wyss, Philipp Müller
  • Publication number: 20230250080
    Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.
    Type: Application
    Filed: March 27, 2023
    Publication date: August 10, 2023
    Inventors: Rebecca Louise DAVIE, Hannah Joy EDWARDS, David Michael EVANS, Simon Teanby HODGSON, Alessandro MAZZACANI, Michael John STOCKS, Thomas Matthew BAKER, Matthew Robert CONROY, Alun John SMITH, David Edward CLARK
  • Patent number: 11642468
    Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.
    Type: Grant
    Filed: November 23, 2018
    Date of Patent: May 9, 2023
    Assignee: Sanofi
    Inventors: Michael Schabbach, Anthony Paul Morris, Ronald Antony Smith, Brian Charles Molyneux, Paul Richard Draper, Craig Ashley Mason, Oliver Charles Gazeley, Daniel Edward Clark, David Aubrey Plumptre, Aidan Michael O'Hare, Richard James Thomas, Felix Kramer, Beat Wyss, Philipp Muller
  • Publication number: 20230139502
    Abstract: The invention provides aza-heterocyclyl carboxamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as bacterial infections, and in inhibiting LpxC activity.
    Type: Application
    Filed: April 27, 2022
    Publication date: May 4, 2023
    Inventors: Michael Dominic Ryan, Thomas David Pallin, Toby Jonathan Blench, Toby Matthew Grover Mullins, David Edward Clark, Emanuela Gancia, Nadia Mamoona Ahmad
  • Publication number: 20230113073
    Abstract: The present invention provides compositions of CD 180 targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease.
    Type: Application
    Filed: December 9, 2022
    Publication date: April 13, 2023
    Inventors: Edward CLARK, Jay Wesley CHAPLIN
  • Patent number: 11613527
    Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: March 28, 2023
    Assignee: KalVista Pharmaceuticals Limited
    Inventors: Rebecca Louise Davie, Hannah Joy Edwards, David Michael Evans, Simon Teanby Hodgson, Alessandro Mazzacani, Michael John Stocks, Thomas Matthew Baker, Matthew Robert Conroy, Alun John Smith, David Edward Clark
  • Publication number: 20230053634
    Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpre S1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.
    Type: Application
    Filed: July 1, 2022
    Publication date: February 23, 2023
    Inventors: Edward A. CLARK, Che-Leung LAW, Deborah FULLER, Michael GALE
  • Patent number: 11549102
    Abstract: The present invention provides compositions of CD180 targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: January 10, 2023
    Assignee: University of Washington
    Inventors: Edward Clark, Jay Wesley Chaplin