Patents by Inventor Edward A. Hunter
Edward A. Hunter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7352920Abstract: A method for managing a digital image of a biological specimen is disclosed. The method includes storing image data in a storage device. The image data is data for showing the image on a display. The method also includes identifying a portion of the image to be processed and transferring a first portion of the image data from the storage device to a working memory. The first portion of the image data is a portion of the image data for displaying the identified portion of the image on the display.Type: GrantFiled: August 26, 2002Date of Patent: April 1, 2008Assignee: Q3DM, LLCInventors: W. Scott Callaway, Edward A. Hunter
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Publication number: 20070016373Abstract: A system, a method, and a programmed device for measurement of translocational activity among cellular compartments process magnified images of cellular material exposed to an agent by segmenting and compartmentalizing the images and then measuring fractional localized intensity of two or more components in the segmented, compartmentalized image. The measured fractional localized intensities are compared to determine translocation of cellular material among the measured components caused by the agent.Type: ApplicationFiled: March 13, 2003Publication date: January 18, 2007Inventors: Edward Hunter, Randall Ingermanson, William Callaway
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Patent number: 7012055Abstract: Fabric treatment compositions comprising a textile compatible carrier and particles having a layered structure comprising oxygen atoms and silicon and/or phosphorus atoms and comprising organic functional groups which are bonded to silicon and/or phosphorus atoms by direct covalent bonds between the silicon and/or phosphorus atoms and a carbon atom. The functional groups are selected to impart lubricating properties to the particles.Type: GrantFiled: April 4, 2003Date of Patent: March 14, 2006Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.Inventors: Paul Hugh Findlay, Joseph Edward Hunter, Laxmikant Tiwari, Nicola Whilton
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Publication number: 20060008522Abstract: A method of preparing an excipient composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and a surfactant, said surfactant being present in an amount from about 0.1% to about 0.5% by weight of the wet-cake microcrystalline cellulose; and drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of microcrystalline cellulose in intimiate association with said surfactant. The excipient may be mixed with a therapeutically active agent to form a dosage form. The surfactant provides a hydrophobic boundary at cellulose surfaces, and improves absorptivity of the therapeutically active agent.Type: ApplicationFiled: July 5, 2005Publication date: January 12, 2006Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John Staniforth, Edward Hunter, Bob Sherwood
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Patent number: 6936277Abstract: A method of preparing an excipient composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and a surfactant, said surfactant being present in an amount from about 0.1% to about 0.5% by weight of the wet-cake microcrystalline cellulose; and drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of microcrystalline cellulose in intimate association with said surfactant. The excipient may be mixed with a therapeutically active agent to form a dosage form. The surfactant provides a hydrophobic boundary at cellulose surfaces, and improves absorptivity of the therapeutically active agent.Type: GrantFiled: May 14, 2002Date of Patent: August 30, 2005Assignee: J. Rettenmaier & Soehne GmbH & Co. KGInventors: John N. Staniforth, Edward A. Hunter, Bob E. Sherwood
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Publication number: 20050185494Abstract: A system and method of assembling an application for processing image or image-derived data is disclosed. The system includes a base operator configured to interface with one or more derivative operator classes, each operator class including an operator object for executing a processing function on the image or image-derived data. A base multiport node class is provided, which is configured to provide a multiport node for each operator object. The multiport nodes instantiates a pluggable operator for connecting the multiport nodes together at runtime according to user-defined parameters. The connection of multiport nodes implements the processing functions of the operator objects to execute the application.Type: ApplicationFiled: April 26, 2005Publication date: August 25, 2005Inventors: W. Callaway, Edward Hunter, Jeffrey Price
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Publication number: 20050147673Abstract: The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a microcrystalline cellulose compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; (ii) inhibits interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces; or (iii) accomplishes both (i) and (ii) above; and (c) an active agent; (2) thereafter drying the resultant aqueous slurry in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.Type: ApplicationFiled: February 8, 2005Publication date: July 7, 2005Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John Staniforth, Edward Hunter, Bob Sherwood, Clifford Davidson
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Patent number: 6886168Abstract: A system and method of assembling an application for processing image or image-derived data is disclosed. The system includes a base operator configured to interface with one or more derivative operator classes, each operator class including an operator object for executing a processing function on the image or image-derived data. A base multiport node class is provided, which is configured to provide a multiport node for each operator object. The multiport nodes instantiates a pluggable operator for connecting the multiport nodes together at runtime according to user-defined parameters. The connection of multiport nodes implements the processing functions of the operator objects to execute the application.Type: GrantFiled: January 19, 2001Date of Patent: April 26, 2005Assignee: Q3DM, LLCInventors: W. Scott Callaway, Edward A. Hunter
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Patent number: 6866867Abstract: The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a microcrystalline cellulose compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; (ii) inhibits interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces; or (iii) accomplishes both (i) and (ii) above; and (c) an active agent; (2) thereafter drying the resultant aqueous slurry in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.Type: GrantFiled: December 13, 2001Date of Patent: March 15, 2005Assignee: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter, Clifford M. Davidson
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Patent number: 6858231Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.Type: GrantFiled: January 8, 2003Date of Patent: February 22, 2005Assignee: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Bob E. Sherwood, John H. Staniforth, Edward A. Hunter
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Patent number: 6852336Abstract: Direct compressed solid pharmaceutical dosage forms containing: a) from about 40 to about 95% by weight acetaminophen; b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; and c) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e.Type: GrantFiled: April 1, 2002Date of Patent: February 8, 2005Assignee: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Edward A. Hunter, Bob E. Sherwood, Joseph A. Zeleznik
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Publication number: 20050013861Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.Type: ApplicationFiled: May 20, 2004Publication date: January 20, 2005Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Bob Sherwood, John Staniforth, Edward Hunter
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Publication number: 20040265374Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2%.Type: ApplicationFiled: April 2, 2004Publication date: December 30, 2004Applicant: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter
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Publication number: 20040127392Abstract: Fabric treatment compositions comprising a textile compatible carrier and particles having a layered structure comprising oxygen atoms and silicon and/or phosphorus atoms and comprising organic functional groups which are bonded to silicon and/or phosphorus atoms by direct covalent bonds between the silicon and/or phosphorus atoms and a carbon atom.Type: ApplicationFiled: April 4, 2003Publication date: July 1, 2004Applicant: Unilever Home & Personal Care USA, Division of Conopco, Inc.Inventors: Paul Hugh Findlay, Joseph Edward Hunter, Laxmikant Tiwari, Nicola Whilton
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Patent number: 6746693Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2%.Type: GrantFiled: October 8, 2002Date of Patent: June 8, 2004Assignee: J. Rettenmaier & Soehne GmbH + Co. KGInventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter
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Publication number: 20030147949Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2%.Type: ApplicationFiled: October 8, 2002Publication date: August 7, 2003Inventors: John N. Staniforth, Bob E. Sherwood, Edward A. Hunter
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Publication number: 20030099702Abstract: A method of preparing an excipient composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and a surfactant, said surfactant being present in an amount from about 0.1% to about 0.5% by weight of the wet-cake microcrystalline cellulose; and drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of microcrystalline cellulose in intimate association with said surfactant. The excipient may be mixed with a therapeutically active agent to form a dosage form. The surfactant provides a hydrophobic boundary at cellulose surfaces, and improves absorptivity of the therapeutically active agent.Type: ApplicationFiled: May 14, 2002Publication date: May 29, 2003Applicant: Penwest Pharmaceuticals Co.Inventors: John N. Staniforth, Edward A. Hunter, Bob E. Sherwood
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Publication number: 20030096005Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.Type: ApplicationFiled: January 8, 2003Publication date: May 22, 2003Inventors: Bob E. Sherwood, John H. Staniforth, Edward A. Hunter
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Patent number: 6521261Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.Type: GrantFiled: October 16, 2001Date of Patent: February 18, 2003Assignee: Edward Mendell Co., Inc.Inventors: Bob E. Sherwood, John H. Staniforth, Edward A. Hunter
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Publication number: 20030033090Abstract: A method for managing a digital image of a biological specimen is disclosed. The method includes storing image data in a storage device. The image data is data for showing the image on a display. The method also includes identifying a portion of the image to be processed and transferring a first portion of the image data from the storage device to a working memory. The first portion of the image data is a portion of the image data for displaying the identified portion of the image on the display.Type: ApplicationFiled: August 26, 2002Publication date: February 13, 2003Inventors: W. Scott Callaway, Edward A. Hunter, Jeffrey H. Price