Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.

Abstract: A computer implemented system enabling information relating to persons or events to be made available by a user to one or more other users, the system including a user interface, a coordinate system, and a mapping application, wherein the user interface enables the user to navigate the coordinate system by the use of the mapping application to identify the person or event, and enter, amend and/or delete information in a database, relating to the person or event.

Abstract: A computer implemented system enabling the discovery of information pertaining to a first user, the system including a user interface for use by first and second users, an image, a mapping application, wherein the user interface enables a first user to anchor information to the image for discovery by one or more second users, and wherein the user interface enables the one or more second users to search the image by use of the mapping application in order to discover anchored information pertaining to the first user.

Abstract: A reclosable lid 310 for a container holding a flowable substance has a cover 312 and a rotatable element 50 rotatably supported by the cover 312. The cover 312 has an opening 28 and a slot 30 located in a top wall 14 of the cover 312. The cover 312 also has a tab 323 extending outward from a portion of the cover 312. The rotatable element 50 has at least one aperture 78 and an actuator 54 that is accessible through the slot 30. The element 50 is moveable by manipulation of the actuator 54 between a first position wherein the aperture 78 is misaligned with the opening 28, and a second position wherein the aperture 78 is aligned with the opening 28. The cover 312 has at least one support member 102 extending radially inward from an inner surface 100 of the cover 312, wherein the support member 102 rotatably supports the element 50.

Abstract: A reclosable lid 10 for a container holding a flowable substance has a first piece or cover 12, and a movable second piece or disk 50. The cover 10 has a top wall 14, a side wall 16 and a mounting portion 22 for connecting the lid 10 on the container. The cover 12 has an opening 28 adapted to permit the flow of the substance through the lid 10. The cover 12 further includes a slot 30 located in the top wall 14. The disk 50 has at least one aperture 78, a post 54, and a projection 52. The aperture 78 and the projection 52 are each cooperatively dimensioned with the opening 28. The post 54 is adapted to be received by the slot 30 in the cover 12. The disk 50 is movable between a first position wherein at least a portion of the projection 52 is received in the opening 28 in the first position, and a second position wherein the aperture 78 is aligned with the opening 28 in the second position.

Abstract: A reclosable lid 10 for a container holding a flowable substance has a first piece or cover 12, and a movable second piece or disk 50. The cover 10 has a top wall 14, a side wall 16 and a mounting portion 22 for connecting the lid 10 on the container. The cover 12 has an opening 28 adapted to permit the flow of the substance through the lid 10. The cover 12 further includes a slot 30 located in the top wall 14. The disk 50 has at least one aperture 78, a post 54, and a projection 52. The aperture 78 and the projection 52 are each cooperatively dimensioned with the opening 28. The post 54 is adapted to be received by the slot 30 in the cover 12. The disk 50 is movable between a first position wherein at least a portion of the projection 52 is received in the opening 28 in the first position, and a second position wherein the aperture 78 is aligned with the opening 28 in the second position.

Abstract: A lid for a container holding a flowable substance has an annular top wall. A side wall depends from the top wall, and has a mounting portion for connecting the lid on the container. The top wall has an opening that is adapted to permit the flow of the substance through the lid. The top wall also has a retaining member. The lid further has a closure member positioned on the mounting portion. The closure member is movable between a first position and a second position, wherein at least a portion of the closure member is received in the opening in the first position and at least a portion of the closure member is received in the retaining member in the second position. The opening and the closure member are cooperatively dimensioned such that the closure member is removably inserted in the opening. The retaining member and the closure member are cooperatively dimensioned such that the closure member is removably inserted in the retaining member.

Abstract: A reclosable lid 310 for a container holding a flowable substance has a cover 312 and a rotatable element 50 rotatably supported by the cover 312. The cover 312 has an opening 28 and a slot 30 located in a top wall 14 of the cover 312. The cover 312 also has a tab 323 extending outward from a portion of the cover 312. The rotatable element 50 has at least one aperture 78 and an actuator 54 that is accessible through the slot 30. The element 50 is moveable by manipulation of the actuator 54 between a first position wherein the aperture 78 is misaligned with the opening 28, and a second position wherein the aperture 78 is aligned with the opening 28. The cover 312 has at least one support member 102 extending radially inward from an inner surface 100 of the cover 312, wherein the support member 102 rotatably supports the element 50.

Abstract: A reclosable lid 10 for a container holding a flowable substance has a first piece or cover 12, and a movable second piece or disk 50. The cover 10 has a top wall 14, a side wall 16 and a mounting portion 22 for connecting the lid 10 on the container. The cover 12 has an opening 28 adapted to permit the flow of the substance through the lid 10. The cover 12 further includes a slot 30 located in the top wall 14. The disk 50 has at least one aperture 78, a post 54, and a projection 52. The aperture 78 and the projection 52 are each cooperatively dimensioned with the opening 28. The post 54 is adapted to be received by the slot 30 in the cover 12. The disk 50 is movable between a first position wherein at least a portion of the projection 52 is received in the opening 28 in the first position, and a second position wherein the aperture 78 is aligned with the opening 28 in the second position.

Abstract: A reclosable lid 10 for a container holding a flowable substance has a first piece or cover 12, and a movable second piece or disk 50. The cover 10 has a top wall 14, a side wall 16 and a mounting portion 22 for connecting the lid 10 on the container. The cover 12 has an opening 28 adapted to permit the flow of the substance through the lid 10. The cover 12 further includes a slot 30 located in the top wall 14. The disk 50 has at least one aperture 78, a post 54, and a projection 52. The aperture 78 and the projection 52 are each cooperatively dimensioned with the opening 28. The post 54 is adapted to be received by the slot 30 in the cover 12. The disk 50 is movable between a first position wherein at least a portion of the projection 52 is received in the opening 28 in the first position, and a second position wherein the aperture 78 is aligned with the opening 28 in the second position.

Abstract: A lid for a container holding a flowable substance has an annular top wall. A side wall depends from the top wall, and has a mounting portion for connecting the lid on the container. The top wall has an opening that is adapted to permit the flow of the substance through the lid. The top wall also has a retaining member. The lid further has a closure member positioned on the mounting portion. The closure member is movable between a first position and a second position, wherein at least a portion of the closure member is received in the opening in the first position and at least a portion of the closure member is received in the retaining member in the second position. The opening and the closure member are cooperatively dimensioned such that the closure member is removably inserted in the opening. The retaining member and the closure member are cooperatively dimensioned such that the closure member is removably inserted in the retaining member.

Abstract: A reclosable lid 10 for a container holding a flowable substance has a first piece or cover 12, and a movable second piece or disk 50. The cover 10 has a top wall 14, a side wall 16 and a mounting portion 22 for connecting the lid 10 on the container. The cover 12 has an opening 28 adapted to permit the flow of the substance through the lid 10. The cover 12 further includes a slot 30 located in the top wall 14. The disk 50 has at least one aperture 78, a post 54, and a projection 52. The aperture 78 and the projection 52 are each cooperatively dimensioned with the opening 28. The post 54 is adapted to be received by the slot 30 in the cover 12. The disk 50 is movable between a first position wherein at least a portion of the projection 52 is received in the opening 28 in the first position, and a second position wherein the aperture 78 is aligned with the opening 28 in the second position.

Abstract: A lid for a container holding a flowable substance has an annular top wall. A side wall depends from the top wall, and has a mounting portion for connecting the lid on the container. The top wall has an opening that is adapted to permit the flow of the substance through the lid. The top wall also has a retaining member. The lid further has a closure member positioned on the mounting portion. The closure member is movable between a first position and a second position, wherein at least a portion of the closure member is received in the opening in the first position and at least a portion of the closure member is received in the retaining member in the second position. The opening and the closure member are cooperatively dimensioned such that the closure member is removably inserted in the opening. The retaining member and the closure member are cooperatively dimensioned such that the closure member is removably inserted in the retaining member.

Abstract: A reclosable lid 10 for a container holding a flowable substance has a first piece or cover 12, and a movable second piece or disk 50. The cover 10 has a top wall 14 , a side wall 16 and a mounting portion 22 for connecting the lid 10 on the container. The cover 12 has an opening 28 adapted to permit the flow of the substance through the lid 10. The cover 12 further includes a slot 30 located in the top wall 14. The disk 50 has at least one aperture 78, a post 54, and a projection 52. The aperture 78 and the projection 52 are each cooperatively dimensioned with the opening 28. The post 54 is adapted to be received by the slot 30 in the cover 12. The disk 50 is movable between a first position wherein at least a portion of the projection 52 is received in the opening 28 in the first position, and a second position wherein the aperture 78 is aligned with the opening 28 in the second position.

Abstract: A method is described for ordering a plurality of messages from a plurality of sources wherein, in order for all the application processes to receive the messages in the same order, a single relay process common to all the sources is selected from the application processes, the other application processes constituting slave processes. All messages broadcast by the sources are rebroadcast from the relay process to all the application processes, including the relay process. The relay process processes data from all messages that it rebroadcasts. The slave process processes only data from messages received via the relay process, data from messages received directly from the sources not being processed. Applications include data processing systems, in particular where part of the software is replicated.

Abstract: A network of interconnected, remotely distributed, location and messaging systems. Each of the remotely distributed location and messaging systems can be dynamically configured to use different frequencies that are assigned to the regions. Each of the remotely distributed location and messaging systems performs location requests for specified subscriber unit using one or more radio frequency transmitting sites and a plurality of radio frequency receiving sites. The location request is initiated by identifying a particular one of the location and messaging systems having a coverage area for the specified subscriber unit. The location request is routed to the identified location and messaging systems, and a unique paging message is transmitted to the subscriber unit. A response is received from the subscriber unit, and forwarded to a processor coupled to the identified location and messaging system.