Abstract: The present invention relates to treatments of hereditary angioedema (HAE). In particular, the present invention provides on-demand treatments of hereditary angioedema (HAE) by orally administering a plasma kallikrein inhibitor to a patient in need thereof on-demand.

Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

Abstract: A tool system for installing a parking pawl includes a tool that includes a base, a plate, and an actuator. The base includes a base surface configured to support a parking pawl in a predetermined position. The plate includes a protrusion that extends upward from a front portion of the plate. A rear portion of the plate is coupled to a front portion of the base. The plate is movable relative to the base between a retention position in which the protrusion is positioned to retain a pawl spring loaded on the parking pawl in a pretensioned state, and a release position in which the protrusion is configured to release the pawl spring. The actuator is operably coupled to the plate such that activation of the actuator moves the plate between the retention position and the release position.

Abstract: Disinfectant compositions are disclosed which provide a durable residual antimicrobial benefit to surfaces treated with such compositions. The disinfectant compositions include a biocidal agent, an amphoteric copolymer, and other functional agents. Methods of making and using the disinfectant compositions are further provided.

Abstract: In one embodiment, a method for auditing the results of a machine learning model includes: retrieving a set of state estimates for original time series data values from a database under audit; reversing the state estimation computation for each of the state estimates to produce reconstituted time series data values for each of the state estimates; retrieving the original time series data values from the database under audit; comparing the original time series data values pairwise with the reconstituted time series data values to determine whether the original time series and reconstituted time series match; and generating a signal that the database under audit (i) has not been modified where the original time series and reconstituted time series match, and (ii) has been modified where the original time series and reconstituted time series do not match.

Abstract: Method for preventing or reducing low speed pre-ignition events in a spark-ignited internal combustion engine is provided. The method includes supplying to the engine the lubricant composition comprising a primary additive having a structure given by or a salt thereof. R1 and R2 are independently H, C1-C20 hydrocarbyl group, carboxyl group, ester, amide, ketone, ether, or hydroxyl group. R3 and R4 are independently H, C1-C20 hydrocarbyl group, carboxyl group, ester, amide, ketone, ether, amino, or hydroxyl group or wherein R3 and R4 are part of a cyclic group. R5 is C1-C100 hydrocarbyl group, carboxyl group, ether, or hydroxyl group. Lastly, p is 0 to 2, n is 1 to 5, m is 0 to 2, and p+n+m is less than 6.

Abstract: A method for securing a plurality of compute nodes includes authenticating a hardware architecture of each of a plurality of components of the compute nodes. The method also includes authenticating a firmware of each of the plurality of components. Further, the method includes generating an authentication database comprising a plurality of authentication descriptions that are based on the authenticated hardware architecture and the authenticated firmware. Additionally, a policy for securing a specified subset of the plurality of compute nodes is implemented by using the authentication database.

Abstract: A bottle comprises a body having an opening in an upper end for receiving fluid; a membrane provided to seal across the opening; and a receptacle sealingly secured to a surface of the membrane within the body. Separation of the membrane from the opening in the receptacle releases the receptacle such that the contents of the receptacle are released into the body.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.

Abstract: A shingle coating asphalt composition is provided that is produced from a paving grade asphalt. The asphalt composition comprises a paving-grade asphalt that has been modified with one or more polymer additives; and a secondary additive comprising one or more of a viscosity reducing agent, a wax, a salt of a fatty acid ester, and an amide of a fatty acid. The shingle coating asphalt coating composition is used to make a shingle. The shingle includes a substrate, the asphalt, and roofing granules.

Abstract: Systems and methods for minimally invasive computer-assisted telesurgery are described. For example, this disclosure describes computer-assisted teleoperated surgery instruments with cable-actuated joint mechanisms Some such joint mechanisms include linkages that maintain the joints in operable configurations without relying on cable tension to do so.

Abstract: A referential amplifier device includes an input port configured to be electrically coupled to a source to receive an input signal from the source at an input voltage level. A first current path system is coupled to the input port and comprises a first transconductor device, a third transconductor device, a first resistor device, and a second resistor device. A second current path system is in parallel with the first current path system and comprises a second transconductor device and a fourth transconductor device. A current level in the second transconductor device is set equal to a current level in the first transconductor device, and a current level in the second transconductor device is set equal to a current level in the fourth transconductor device. An output port is coupled to the second current path system and configured to provide an output voltage based on a difference between the input voltage level and a threshold voltage level for the referential amplifier device.

Abstract: Disposable absorbent articles suitable for providing leakage protection for users that experience relatively small to relatively large discharges of fluids are described. The article includes a primary topsheet, a backsheet, and an absorbent system disposed between the topsheet and the backsheet. The absorbent system includes a first absorbent core and a second absorbent core, and wherein the primary topsheet and at least the first absorbent core include a plurality of recessed areas.

Abstract: The present invention relates to treatments of bradykinin-mediated angioedema. In particular, the present invention provides on-demand treatments of bradykinin-mediated angioedema by orally administering a plasma kallikrein inhibitor to a patient in need thereof on-demand as an oral dosage form particularly suitable for patients who may struggle to swallow tablets.

Abstract: Disclosed herein are systems and methods for scalable and secure transmission of multicast data over a public communication network. In exemplary embodiments of the present disclosure, a virtual overlay network can be presented as a single virtual interface to a computing device, for the receipt and transfer of multicast data in a secure and scalable manner across a public insecure communication network.

Abstract: Systems and methods for coupling a tag to an item. The methods comprise: dispensing the tag from a tag feeder of a tag applicator; performing first operations by the tag applicator to mechanically move the tag into a nest of the tag applicator; determining if a given criteria is met based on feedback information received from at least one of a user of the tag applicator and a sensor provided with the tag applicator; and performing second operations by the tag applicator to couple the tag to the item, when a determination is made that the given criteria is met.

Abstract: Systems and methods for coupling a tag to an item. The methods comprise: dispensing the tag from a tag feeder of a tag applicator; performing first operations by the tag applicator to mechanically move the tag into a nest of the tag applicator; determining if a given criteria is met based on feedback information received from at least one of a user of the tag applicator and a sensor provided with the tag applicator; and performing second operations by the tag applicator to couple the tag to the item, when a determination is made that the given criteria is met.

Abstract: Provided here are therapeutically effective pharmaceutical compositions containing one or more TREX2 inhibitors, and more specifically methods of administering TREX2 inhibitors to increase the effectiveness of a chemotherapeutic agent. Also provided here are methods of identifying agents that inhibit the exonuclease activity of TREX2.

Abstract: Methods and systems are disclosed for generating a view of data to emphasize similar orders or patterns. Based on a pattern associated with a particular characteristic in a set of data, at least a subset of a plurality of data groupings to display is determined. For a particular subset of data groupings to display, a first graphical object is generated. A second graphical object represents an executable algorithm. After detecting user input causing a change in placement of the second graphical object in relation to the first graphical object, an automatic operation indicated by the executable algorithm is executed in connection with an item in the at least one order grouping indicated by the first graphical object.

Abstract: The present disclosure relates generally to security tags, and more specifically relates to electronic article surveillance (EAS) tags. The tag prevents unauthorized removal of an article as well as triggers an alarm when the tag is attempted for tampering. The tag comprises a housing, a switch, and a processing circuit. The switch includes a first contact coupled with the housing and a second contact coupled with an article. The second contact is movable relative to the first contact. The processing circuit is provided to detect electrical disconnection between the first contact and the second contact, and trigger an alarm upon detecting the electrical disconnection.