Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof, that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: A hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a substantially non-expandable, non-compressible prosthetic valve member having a peripheral sealing ring and an expandable stent frame projecting from an inflow end, thereby enabling attachment to the annulus without sutures. The stent frame may be plastically-expandable and may have a thin fabric layer covering its entirety as well as secondary sealing structures around its periphery to prevent paravalvular leaking. Other sealing solutions include interactive steps at the time of valve implant to establish seals around the stent and especially between the stent and the sealing ring of the valve member.

Abstract: A device and method for measuring angles of orientation of an x-ray imaging system including an x-ray source, an x-ray detector and a sample holder arranged to receive a sample to be analysed. The method includes: emitting a polychromatic x-ray beam through a reference sample installed on the sample holder in order to form a diffraction pattern on the sensing area of the x-ray detector, generating, with the x-ray detector, an observed image comprising the diffraction pattern, and determining the orientation of the x-ray source and the orientation of the x-ray detector by comparing the observed image with at least one target image comprising a diffraction pattern obtained for the reference sample with preset orientations of the x-ray source and of the x-ray detector.

Abstract: A hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a substantially non-expandable, non-compressible prosthetic valve member having a peripheral sealing ring and an expandable stent frame projecting from an inflow end, thereby enabling attachment to the annulus without sutures. The stent frame may be plastically-expandable and may have a thin fabric layer covering its entirety as well as secondary sealing structures around its periphery to prevent paravalvular leaking. Other sealing solutions include interactive steps at the time of valve implant to establish seals around the stent and especially between the stent and the sealing ring of the valve member.

Abstract: Provided is a control unit for displaying a network load sustained on a networking cable. The control unit requests a current network load of the networking cable from a monitoring circuit. The control unit receives the current network load from the monitoring circuit. The control unit instructs a visual indicator to display the current network load of the networking cable.

Abstract: A method for controlling the crystallographic orientation of at least one grain of a turbo engine part. The method includes emitting a beam of electromagnetic radiation through an elementary volume of the part and record diffraction information on the electromagnetic radiation passing through the part. This step is repeated on a given area of the part. The method further includes determining the crystal spatial orientation of each of said elementary volumes and deducing the presence of at least one first crystallographic grain for which the elementary volumes are oriented according to the same crystallographic orientation. The method further includes calculating the angular difference between the crystal spatial orientation of said first grain and a predetermined direction taken from the part and comparing it to a first predetermined threshold value and determining a state of use of the part.

Abstract: A method for controlling the crystallographic orientation of at least one grain of a turbo engine part. The method includes emitting a beam of electromagnetic radiation through an elementary volume of the part and record diffraction information on the electromagnetic radiation passing through the part. This step is repeated on a given area of the part. The method further includes determining the crystal spatial orientation of each of said elementary volumes and deducting the presence of at least one first crystallographic grain for which the elementary volumes are oriented according to the same crystallographic orientation. The method further includes calculating the angular difference between the crystal spatial orientation of said first grain and a predetermined direction taken from the part and comparing it to a first predetermined threshold value and determining a state of use of the part.

Abstract: The method of non-destructive inspection is carried out on an aviation part by a digital imaging system including a source of electromagnetic rays and a detector, and the method includes a prior step of estimating settings for the digital imaging system, which step includes: obtaining a digital model characterizing the digital imaging system and including models characterizing the source and the detector; obtaining a digital model characterizing the aviation part; evaluating a contrast-to-noise ratio for the digital imaging system and the aviation part for a plurality of distinct values of the settings, by making use of the digital models that have been obtained characterizing the digital imaging system and the aviation part; and determining optimum values for the settings that optimize the contrast-to-noise ratio and that are applied to the digital imaging system during a setting up step.

Abstract: Provided is a control unit for displaying a network load sustained on a networking cable. The control unit requests a current network load of the networking cable from a monitoring circuit. The control unit receives the current network load from the monitoring circuit. The control unit instructs a visual indicator to display the current network load of the networking cable.

Abstract: A method is provided that includes accessing, by a debugging device associated with an external user device, (i) a serial console of a hardware network device, and (ii) a management Ethernet port of the hardware network device. The method includes providing, by the debugging device, (i) a serial console interface from the serial console of the hardware network device to the external user device, and (ii) a management Ethernet interface from the management Ethernet port of the hardware network device to the external user device. The method includes receiving, by serial console interface and the management Ethernet interface of the debugging device, user input from the external user device. The method includes sending, using a hardware bypass in the debugging device. Ethernet management traffic from the hardware network device to the external user device through an internal network, responsive to the debugging device improperly operating.

Abstract: The method of non-destructive inspection is carried out on an aviation part by a digital imaging system including a source of electromagnetic rays and a detector, and the method includes a prior step of estimating settings for the digital imaging system, which step includes: obtaining a digital model characterizing the digital imaging system and including models characterizing the source and the detector; obtaining a digital model characterizing the aviation part; evaluating a contrast-to-noise ratio for the digital imaging system and the aviation part for a plurality of distinct values of the settings, by making use of the digital models that have been obtained characterizing the digital imaging system and the aviation part; and determining optimum values for the settings that optimize the contrast-to-noise ratio and that are applied to the digital imaging system during a setting up step.

Abstract: A method is provided that includes accessing, by a debugging device associated with an external user device, (i) a serial console of a hardware network device, and (ii) a management Ethernet port of the hardware network device. The method includes providing, by the debugging device, (i) a serial console interface from the serial console of the hardware network device to the external user device, and (ii) a management Ethernet interface from the management Ethernet port of the hardware network device to the external user device. The method includes receiving, by serial console interface and the management Ethernet interface of the debugging device, user input from the external user device. The method includes sending, using a hardware bypass in the debugging device, Ethernet management traffic from the hardware network device to the external user device through an internal network, responsive to the debugging device improperly operating.

Abstract: A method and fiber optic coupling system are provided. The method includes establishing that a physical coupling has occurred between a fiber optic cable and a fiber optic Small Form-factor Pluggable (SFP). The fiber optic cable includes a cable magnetic connector. The fiber optic SFP includes a SFP magnetic connector having a plurality of magnetic switches. The fiber optic SFP is operably coupled to a SFP circuit board, an emitter, and a receiver. The method further includes determining that the cable magnetic connector has applied a magnetic field to the plurality of magnetic switches. The method further includes activating the emitter and the receiver, responsive to the magnetic field being applied to the plurality of magnetic switches.

Abstract: An coupon distribution and processing platform system allows its members/constituents to receive services associated with the purchase of consumer products. Specifically, a user, registered with the system, accesses an account and electronically selects one or more coupons to be associated with a card device. Thereafter, when the user's card device is scanned at a particular retail entity, the accounts associated with the user and retail entity are credited, while the account associated with the manufacturer is debited. Further, the user, the manufacturer, and the retail entity, each having a corresponding account, may select one or more services provided by with the system website.

Abstract: A coupon distribution and processing platform (CDPP) allows its members/constituents to receive services associated with the purchase of consumer products. Specifically, a shopper, registered with the CDPP, accesses an account and electronically selects one or more coupons to be associated with a coupon card. Thereafter, when the shopper's coupon card is scanned or credit card is scanned at a particular grocer entity, the accounts associated with the shopper and grocer entity are credited, while the account associated with the manufacturer is debited. Further, the shopper, the manufacturer, and the grocer entity, each having a corresponding account, may select one or more services provided by the CDPP utilizing by a CDPP website.

Abstract: An iron type golf club head having a face with a parabolic cross-sectional shape of the face from the heel to the toe of the head.

Abstract: Ventilated (air-cooled) shoes and other footwear having a plurality of crosswise passages opening to the outside of the sole portion on the sides of the footwear, and in which each of the crosswise passages has at least one upright channel opening on the top of the sole portion.

Abstract: A capacitive discharge ignition (CDI) system for generating ignition sparks in an internal combustion engine comprises a single CDI module including a plurality of charge storage capacitor devices, a corresponding plurality of sets of ignition outputs, at least one charging circuit for charging at least one of the plurality of charge storage capacitor devices, and an ignition controller for selectively and individually controlling each of the plurality of charge storage capacitor devices and the at least one power supply circuit. Each of the plurality of charge storage capacitor devices is operatively coupled to the ignition outputs of one of the plurality of sets of ignition outputs. This allows for the single CDI module to power multiple, independent spark plugs either simultaneous of, immediately prior to or after each other while still delivering full energy to each ignition device.

Abstract: A tool for creating grooves or cut-away portions in the inwardly extending corrugations of a flexible corrugated hose in order to eliminate noises created by movements of fluids, such as air, through the interior passage of the hose. The tool is a generally cylindrical member having outwardly extending fins extending at an angle to the longitudinal direction thereof. The tool is placed within the hose and relative movement in an axial or longitudinal direction causes the fins to act as cutting members and create the grooves or cut portions. The movement causes the fins to create an angled pattern of grooves relative to the axial direction.

Abstract: A corrugated non-reinforced polymeric flexible hose which has at least the outer crests formed with flat apices. The valleys of the corrugations may also have flat apices. The crests and valleys are connected by side walls extending at a shallow angle.