Abstract: One aspect of the present application relates to a pharmaceutical composition comprising a sulfated glycosaminoglycan having an average molecular weight ranging from 3,000 to 15,000 Daltons, a skin penetrating agent, where the skin penetrating agent promotes transdermal penetration of the sulfated glycosaminoglycan when applied to intact skin surfaces, and a pharmaceutical carrier for topical application, where the pharmaceutical carrier is mixed with the sulfated glycosaminoglycan and the skin penetrating agent. This composition is useful in carrying out a method of treating a subject for pain, joint stiffness, soft tissue injury, connective tissue disorders, and/or muscle soreness.

Abstract: Provided are compositions that are stable formulations of a hyaluronan-degrading enzyme or are stable co-formulations of a fast-acting insulin and a hyaluronan degrading enzyme, including a recombinant human PH20 (rHuPH20).

Abstract: Provided herein are modified anti-EGFR antibodies and nucleic acid molecules encoding modified anti-EGFR antibodies. Also provided are methods of treatment and uses using modified anti-EGFR antibodies.

Abstract: An electric drive module for use in electric vehicles includes an electric traction motor, a geared reduction unit driven by the electric motor, a differential unit interconnecting a pair of axleshafts to a pair of wheels, and a disconnect mechanism for selectively coupling and uncoupling the geared reduction unit and the differential unit. The disconnect mechanism is configured to normally couple the geared reduction unit to the differential unit. The disconnect mechanism uncouples the geared reduction unit from the differential unit to prevent peak torque transients and torque reversals between the electric motor and the wheels.

Abstract: Provided herein are modified anti-EGFR antibodies and nucleic acid molecules encoding modified anti-EGFR antibodies. Also provided are methods of treatment and uses using modified anti-EGFR antibodies.

Abstract: Provided are methods for continuous subcutaneous insulin infusion (CSII) that employ a hyaluronan-degrading enzyme, including a recombinant human PH20 (rHuPH20). The methods can be used to more consistently control blood glucose during the course of CSII. The methods can be used to treat subjects having diabetes or other insulin-associated disease or condition.

Abstract: Provided are compositions that are stable formulations of a hyaluronan-degrading enzyme or are stable co-formulations of a fast-acting insulin and a hyaluronan degrading enzyme, including a recombinant human PH20 (rHuPH20).

Abstract: Provided are compositions that are stable formulations of a hyaluronan-degrading enzyme or are stable co-formulations of a fast-acting insulin and a hyaluronan degrading enzyme, including a recombinant human PH20 (rHuPH20).

Abstract: A molded article, for example, a filter or a preform used in the manufacture of fiber-reinforced composites, is manufactured from an air laid batt from a single fiber type or a mixture of fibers. The batt is either resinated with a thermoplastic material or includes a thermoplastic binder fiber. The batt is formed into the desired shape of the molded article in a through-air mold and heated sufficiently to set the thermoplastic material, so that the resulting article retains the desired shape. If the article is to be used as a fluid filter, it can be used either as it is removed from the mold if a filter of uniform density is desired, of the article can be further processed in a compression mold to densify portions of the article to thereby form, for example, a fluid impervious portion used as a gasket. If the article is to be used as a preform for a structural composite, it is then to be transferred to a resin injection mold.

Abstract: A fiber reinforced, composite article is manufactured by forming a nonwoven, air-laid batt from a single fiber type or a mixture of fibers. The batt is either resinated with a thermoplastic material or includes a thermoplastic binder fiber. The batt is formed into a preform having the desired shape in a through-air mold and heated sufficiently to set the thermoplastic material, so that the resulting preform retains the desired shape and is sufficiently stiff to withstand the pressure of the injected resin. The preform is then transferred to a resin injection mold, where the interstices between the fibers are saturated with an appropriate resin matrix. As the fibers of the preform are saturated (or after a saturation but before the resin sets) the resin transfer mold is compressed, thereby forming the preform into its final desired thickness and increasing the concentration of the fibers to give the preform appropriate strength.

Abstract: A product formed of a plurality of unstable layers of textile fiber pleated together with both the layers and the pleats in close contact, forming a stable body the upper and lower surfaces of which are formed by the folds between the pleats.

Abstract: A method and machine for forming nonwoven batts containing refractory fibers such as carbon, glass, ceramic or metallic fibers, includes a conveying table (12) provided with scalloped rollers (90, 92) which separate tows of filaments (16) and spread the filaments on a conveying table. A feed roller (80) holds the filaments on the table so that they are conveyed to a rotating lickerin (60). The lickerin (60) is provided with teeth (62) which grasp the filaments so that a tensile force is applied thereto, thereby breaking the filaments at structurally weak points in the filaments. The fibers are mixed with textile fibers and transferred to a foraminous condenser (144) by blowing the fibers through a duct (112). The fibers are arranged on the conveyor (114) in a random fashion to form a batt.