Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.

Abstract: A multi-tiered work arrangement includes stacked horizontal planar surfaces that have footprints that enable stacking of the planar surfaces to provide work surfaces that are easily accessible to a user in both a sitting and a standing position. A first work surface can have a wide end and a narrow end, and a second work surface can have corresponding narrow and wide ends. The wide end of the first planar surface is substantially equivalent in length to the narrow end of the second planar surface such that the work surfaces can be stacked in use, providing two unobstructed work surfaces at different heights.

Abstract: Latches and latch systems configured for providing an access indication are disclosed. One latch comprises an actuator, an indicator, and a reset mechanism. The actuator has an unopened position and an opened position. The indicator has a first position in which the indicator provides a first indication and a second position in which the indicator provides a second indication. The indicator is configured to move from the first position to the second position when the actuator is moved from the unopened position toward the opened position. The reset mechanism is configured to move the indicator from the second position to the first position. Once the indicator is moved from the first position to the second position, it is configured to remain in the second position independent of movement of the actuator until the reset mechanism moves the indicator to the first position from the second position.

Abstract: A multi-tiered work arrangement includes stacked horizontal planar surfaces that have footprints that enable stacking of the planar surfaces to provide work surfaces that are easily accessible to a user in both a sitting and a standing position. A first work surface can have a wide end and a narrow end, and a second work surface can have corresponding narrow and wide ends. The wide end of the first planar surface is substantially equivalent in length to the narrow end of the second planar surface such that the work surfaces can be stacked in use, providing two unobstructed work surfaces at different heights.

Abstract: A multi-tiered work arrangement includes stacked horizontal planar surfaces that have footprints that enable stacking of the planar surfaces to provide work surfaces that are easily accessible to a user in both a sitting and a standing position. A first work surface can have a wide end and a narrow end, and a second work surface can have corresponding narrow and wide ends. The wide end of the first planar surface is substantially equivalent in length to the narrow end of the second planar surface such that the work surfaces can be stacked in use, providing two unobstructed work surfaces at different heights.

Abstract: Latches and latch systems configured for providing an access indication are disclosed. One latch comprises an actuator, an indicator, and a reset mechanism. The actuator has an unopened position and an opened position. The indicator has a first position in which the indicator provides a first indication and a second position in which the indicator provides a second indication. The indicator is configured to move from the first position to the second position when the actuator is moved from the unopened position toward the opened position. The reset mechanism is configured to move the indicator from the second position to the first position. Once the indicator is moved from the first position to the second position, it is configured to remain in the second position independent of movement of the actuator until the reset mechanism moves the indicator to the first position from the second position.

Abstract: A multi-tiered work arrangement includes stacked horizontal planar surfaces that have footprints that enable stacking of the planar surfaces to provide work surfaces that are easily accessible to a user in both a sitting and a standing position. A first work surface can have a wide end and a narrow end, and a second work surface can have corresponding narrow and wide ends. The wide end of the first planar surface is substantially equivalent in length to the narrow end of the second planar surface such that the work surfaces can be stacked in use, providing two unobstructed work surfaces at different heights.

Abstract: Anti-uPA antibodies and antigen-binding regions thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding regions, are described. Also described are methods of using such antibodies and antigen-binding regions to bind uPA epitopes and activate uPA function, such as inhibition of uPA mediated inflammation. Epitopes that can be used to activate uPA function and anti-inflammation activity are also described, as well as methods of identifying compounds that can bind them.

Abstract: Anti-uPA antibodies and antigen-binding regions thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding regions, are described. Also described are methods of using such antibodies and antigen-binding regions to bind uPA epitopes and activate uPA function, such as inhibition of uPA mediated inflammation. Epitopes that can be used to activate uPA function and anti-inflammation activity are also described, as well as methods of identifying compounds that can bind them.

Abstract: Radiolabeled adenosine or radiolabeled adenosine containing molecules for use in positron emission tomography for assessing alterations in adenylate metabolism in a patient are provided.

Abstract: Disclosed are methods for treating conditions resulting from hyperoxia or mechanical ventilation comprising the administration of a compound of the formula: ##STR1## wherein R.sub.1 is a substantially pure resolved R enantiomer .omega.-1, secondary alcohol-substituted (C.sub.5-8) alkyl; and R.sub.2 and R.sub.3 are independently hydrogen atom or a (C.sub.1-12) alkyl optionally containing one or two oxygen atoms in place of non-adjacent carbon atoms.

Abstract: Previously unisolated serum immunoregulatory polypeptides (SIPs) having a molecular weight of approximately 14,000 to 31,000 are provided. The SIPs may be obtained from hemorrhagic serum of mammals and have been shown to activate suppressor T-cells and suppress lymphocyte proliferation and interleukin production. There is a significant homology between SIPs of different mammalian species. The amino acid sequence of an SIP having a molecular weight of about 16,000 is provided. In addition, immunosuppressive polypeptides are identified which have the formula (SEQ ID NO:2):X-Met-Asp-Ala-His-Pro-Pro-Arg-Leu-Phe-Ala-Cys-Ser-Ywherein X is an amino acid sequence having from 0 to 10 amino acids and Y is an amino acid sequence having from 0 to 110 amino acids.

Abstract: Previously unisolated serum immunoregulatory polypeptides (SIPs) having a molecular weight of approximately 14,000 to 31,000 are provided. The SIPs may be obtained from hemorrhagic serum of mammals and have been shown to activate suppressor T-cells and suppress lymphocyte proliferation and interleukin production. There is a significant homology between SIPs of different mammalian species. The amino acid sequence of an SIP having a molecular weight of about 16,000 is provided. In addition, immunosuppressive polypeptides are identified which have the formula:X-Met-Asp-Ala-His-Pro-Pro-Arg-Leu-Phe-Ala-Cys-Ser-Ywherein X is an amino acid sequence having from 0 to 10 amino acids and Y is an amino acid sequence having from 0 to 110 amino acids.