Patents by Inventor Edward Appelbaum

Edward Appelbaum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • WAY TO OBTAIN HIGH EXPRESSION CLONES OF MAMMALIAN CELLS USING A METHYLCELLULOSE WITH FLUORESCENT PROTEIN A OR G AND FLUORESCENT SCREENING METHOD
    Publication number: 20100028904
    Abstract: The invention provides a genetic screening method for identifying a transfected cell expressing the polypeptide of interest. The methods allows for high throughput screening of recombinant cells for elevated levels of expression of the polypeptide of interest using methylcellulose comprising fluorescent protein A or G to improve detection and cloning. The invention also provides capture media, formulations and methods of making and using thereof.
    Type: Application
    Filed: March 28, 2008
    Publication date: February 4, 2010
    Applicant: CENTOCOR, INC.
    Inventors: Edward Appelbaum, Susanne Corisdeo, Subiney Ganguly, Dennis M. Kraichely, Sunil Mehta, Gordon Moore, Richard Siegel
  • Human Chemokines CKBeta-4 and CKBeta-10/MCP-4
    Publication number: 20070238644
    Abstract: Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
    Type: Application
    Filed: November 21, 2006
    Publication date: October 11, 2007
    Applicant: Human Genome Sciences, Inc.
    Inventors: Haodong Li, Mark Adams, Solange Lima, Ralph Alderson, Yuling Li, David Parmelee, John White, Edward Appelbaum
  • Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
    Publication number: 20060029594
    Abstract: Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
    Type: Application
    Filed: October 20, 2005
    Publication date: February 9, 2006
    Inventors: Robert Ames, Edward Appelbaum, Irwin Chaiken, Richard Cook, Mitchell Gross, Stephen Holmes, Lynette McMillan, Timothy Theisen
  • Antibodies to human CK&bgr;-10/MCP-4
    Patent number: 6673344
    Abstract: Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: January 6, 2004
    Assignee: Human Genome Sciences, Inc.
    Inventors: Haodong Li, Mark Adams, Solange Hanschke Lima, Ralph Alderson, Yuling Li, David Parmelee, John White, Edward Appelbaum
  • Short forms of chemokine beta-8
    Publication number: 20030138400
    Abstract: Novel polypeptides of the truncated form of human Ck&bgr;-8 are provided. Methods for using the polypeptides are also provided.
    Type: Application
    Filed: August 20, 2002
    Publication date: July 24, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: John White, Edward Appelbaum, Daniel O'Shannessy, James Allan Fornwald, Kevin O'Donnell
  • Short forms of chemokine beta-8
    Publication number: 20020007047
    Abstract: Novel polypeptides of the truncated form of human Ck&bgr;-8 are provided. Methods for using the polypeptides are also provided.
    Type: Application
    Filed: February 8, 2001
    Publication date: January 17, 2002
    Inventors: John White, Edward Appelbaum, Daniel O'Shannessy, James Allan Fornwald, Kevin O'Donnell