Patents by Inventor Edward B. Cambareri

Edward B. Cambareri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8163533
    Abstract: The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of filamentous fungal heterokaryons that are generated from combinations of two or more parent strains into which recombinant DNA molecules encoding variants of antigens derived from pathogenic organisms have been introduced. The resulting vaccines are multivalent.
    Type: Grant
    Filed: October 17, 2005
    Date of Patent: April 24, 2012
    Assignee: Intrexon Corporation
    Inventors: W. Dorsey Stuart, Edward B. Cambareri
  • Publication number: 20080318274
    Abstract: The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of filamentous fungal heterokaryons that are generated from combinations of two or more parent strains into which recombinant DNA molecules encoding variants of antigens derived from pathogenic organisms have been introduced. The resulting vaccines are multivalent.
    Type: Application
    Filed: October 17, 2005
    Publication date: December 25, 2008
    Applicant: Neugenesis Corporation
    Inventors: W. Dorsey Stuart, Edward B. Cambareri
  • Patent number: 7323299
    Abstract: Methods and compositions are provided for the efficient in vivo diversification of gene-products in filamentous fungi, starting from (but not limited to) two or more copies of a single gene constituent. The diversification involve use of the Repeat-Induced Point mutation (RIP) process in N. crassa, and other fungi that have analogous mutational processes. The invention takes advantage of the induction of G:C to A:T transition mutations specific to duplicated DNA sequences during the premeiotic dikaryon phase of the life cycle of the fungus. The methods and compositions of the invention can be utilized to generate diversity in target genes, and are proposed for the purpose of altering and generating novel forms and activities of gene-products thus encoded. Duplicated genes may be introduced into the organism and are present either in tandem, or at separate ectopic locations within the genome of the fungus.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: January 29, 2008
    Assignee: Neugenesis Corporation
    Inventors: Edward B. Cambareri, Eli E. Kato
  • Publication number: 20030215933
    Abstract: Methods and compositions are provided for the efficient in vivo diversification of gene-products in filamentous fungi, starting from (but not limited to) two or more copies of a single gene constituent. The diversification involve use of the Repeat-Induced Point mutation (RIP) process in N. crassa, and other fungi that have analogous mutational processes. The invention takes advantage of the induction of G:C to A:T transition mutations specific to duplicated DNA sequences during the premeiotic dikaryon phase of the life cycle of the fungus. The methods and compositions of the invention can be utilized to generate diversity in target genes, and are proposed for the purpose of altering and generating novel forms and activities of gene-products thus encoded. Duplicated genes may be introduced into the organism and are present either in tandem, or at separate ectopic locations within the genome of the fungus.
    Type: Application
    Filed: April 15, 2003
    Publication date: November 20, 2003
    Inventors: Edward B. Cambareri, Eli E. Kato