Patents by Inventor Edward B. Neufeld

Edward B. Neufeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR ASSESSING CARDIOVASCULAR DISEASE OR INFLAMMATORY DISEASE RISK USING NON-EXCHANGEABLE LIPID PROBE
    Publication number: 20220178953
    Abstract: A method of assessing the risk for development of cardiovascular disease (CVD) or an inflammatory disease in a patient comprises (i) incubating a sample of body fluid with donor particles, wherein the donor particles are coated with a lipid and a first quantity of detectably labeled, non-exchangeable lipid probe (NELP); (ii) separating the detectably labeled NELP-associated HDL into a first portion and the donor particles into a second portion; (iii) measuring the second quantity of detectably labeled NELP in the first portion; (iv) determining a detectably labeled NELP efflux value for the patient; and (v) comparing the detectably labeled NELP efflux value for the patient to a reference standard. Related methods of lowering the risk for development of CVD or an inflammatory disease in a patient and methods of measuring the quantity of functional HDL in a sample of body fluid are also provided.
    Type: Application
    Filed: March 6, 2020
    Publication date: June 9, 2022
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Alan T. Remaley, Edward B. Neufeld, Masaki Sato
  • Multi-domain amphipathic helical peptides and methods of their use
    Patent number: 8835378
    Abstract: Disclosed herein are peptides or peptide analogs with multiple amphipathic ?-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic ?-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: September 16, 2014
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Alan T. Remaley, Stephen J. Demosky, John A. Stonik, Marcelo J. A. Amar, Edward B. Neufeld, H. Bryan Brewer, Fairwell Thomas
  • MULTI-DOMAIN AMPHIPATHIC HELICAL PEPTIDES AND METHODS OF THEIR USE
    Publication number: 20120148642
    Abstract: Disclosed herein are peptides or peptide analogs with multiple amphipathic ?-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic ?-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
    Type: Application
    Filed: February 28, 2012
    Publication date: June 14, 2012
    Applicants: Health and Human Services
    Inventors: Alan T. Remaley, Stephen J. Demosky, John A. Stonik, Marcelo J.A. Amar, Edward B. Neufeld, H. Bryan Brewer, Fairwell Thomas
  • Method of treating or inhibiting inflammation by multi-domain amphipathic helical peptides
    Patent number: 8148323
    Abstract: Disclosed herein are peptides or peptide analogs with multiple amphipathic ?-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic ?-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: April 3, 2012
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Alan T. Remaley, Stephen J. Demosky, John A. Stonik, Marcelo J. A. Amar, Edward B. Neufeld, H. Bryan Brewer, Fairwell Thomas
  • Isolated nucleic acid molecule encoding a peptide or peptide analog comprising the SEQ ID No. 3
    Patent number: 8071746
    Abstract: Disclosed herein are peptides or peptide analogs with multiple amphipathic ?-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic ?-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: December 6, 2011
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Alan T. Remaley, Stephen J. Demosky, John A. Stonik, Marcele J. A. Amar, Edward B. Neufeld, Bryan H. Brewer, Fairwell Thomas
  • MULTI-DOMAIN AMPHIPATHIC HELICAL PEPTIDES AND METHODS OF THEIR USE
    Publication number: 20100203099
    Abstract: Disclosed herein are peptides or peptide analogs with multiple amphipathic ?-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic ?-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
    Type: Application
    Filed: April 23, 2010
    Publication date: August 12, 2010
    Inventors: ALAN T. REMALEY, STEPHEN J. DEMOSKY, JOHN A. STONIK, MARCELE J.A. AMAR, EDWARD B. NEUFELD, H. BRYAN BREWER, FAIRWELL THOMAS
  • MULTI-DOMAIN AMPHIPATHIC HELICAL PEPTIDES AND METHODS OF THEIR USE
    Publication number: 20090270331
    Abstract: Disclosed herein are peptides or peptide analogs with multiple amphipathic ?-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic ?-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
    Type: Application
    Filed: July 2, 2009
    Publication date: October 29, 2009
    Inventors: Alan T. Remaley, Stephen J. Demosky, John A. Stonik, Marcele J.A. Amar, Edward B. Neufeld, Bryan H. Brewer, Fairwell Thomas
  • Multi-domain amphipathic helical peptides and methods of their use
    Patent number: 7572771
    Abstract: Disclosed herein are peptides or peptide analogs with multiple amphipathic ?-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic ?-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: August 11, 2009
    Assignee: The United States of America as represented by the Departments of Health and Human Services
    Inventors: Alan T. Remaley, Stephen J. Demosky, John A. Stonik, Marcele J. A. Amar, Edward B. Neufeld, H. Bryan Brewer, Fairwell Thomas