Abstract: A battery housing assembly for an electric vehicle includes a battery housing, at least one mounting structure, and a strike bar. The battery housing is configured to house battery components. The mounting structure is secured to the battery housing and is configured to mount the battery housing to a vehicle frame. The mounting structure includes a recess. The strike bar is disposed within the recess and is secured to the mounting structure. The strike bar extends beyond an exterior profile of the battery housing and includes an upper end portion that tapers inwardly within the recess. The strike bar is configured to detach from the mounting structure in a downward direction during a vehicle impact event.

Abstract: A power cell and a method of assembling a power cell is described. The power cell comprises a valve operable to vent gas from a power cell housing, the valve comprising a first alignment feature. The power cell further comprises a duct attachable to the power cell housing and configured to direct gas released from the valve, wherein the duct comprises a second alignment feature configured to cooperate with the first alignment feature of the valve, in an assembled configuration.

Abstract: Systems and methods for operating an electric power distribution bus of an electric or hybrid vehicle are described. In one example, an output of an electric power consumer is decoupled from other electric power consumers so that electric current drawn from the electric power distribution bus is lowered while the electric power consumer provides a capacitive load to the electric power distribution bus, thereby reducing voltage ripple associated with the electric power distribution bus.

Abstract: A vehicle includes an internal combustion engine, an electric machine, and a controller. The electric machine is rotatably coupled to the engine and is configured to deliver electrical power to electrical accessories. The controller is programmed to, in response to a control signal loss between the electric machine and the controller, limit torque output of electric machine to less than a torque threshold that corresponds to the power threshold. The controller is further programmed to, in response an accessory power demand being greater than the power threshold, control the engine to power the electric machine to increase the torque output of electric machine to greater than the torque threshold to meet the accessory power demand.

Abstract: Systems and methods for operating an electric power distribution bus of an electric or hybrid vehicle are described. In one example, an output of an electric power consumer is decoupled from other electric power consumers so that electric current drawn from the electric power distribution bus is lowered while the electric power consumer provides a capacitive load to the electric power distribution bus, thereby reducing voltage ripple associated with the electric power distribution bus.

Abstract: A vehicle includes an internal combustion engine, an electric machine, and a controller. The electric machine is rotatably coupled to the engine and is configured to deliver electrical power to electrical accessories. The controller is programmed to, in response to a control signal loss between the electric machine and the controller, limit torque output of electric machine to less than a torque threshold that corresponds to the power threshold. The controller is further programmed to, in response an accessory power demand being greater than the power threshold, control the engine to power the electric machine to increase the torque output of electric machine to greater than the torque threshold to meet the accessory power demand.

Abstract: A method includes receiving fault management data and service quality management data from an integrated feedback control loop, wherein a first set of faults in the fault management data is correlated with service quality management data if a root cause of the first set of faults is known and wherein a second set of faults in the fault management data are categorized as silent faults if no root cause of the second faults is known, The silent faults in the fault management are correlated with the service quality management data. The disclosure includes prioritizing analysis of the silent faults that affect the service quality management data, and prioritizing repair of faults in the fault management data that affect the service quality management data.

Abstract: A method includes collecting operational data from a system, segregating the data into a first component comprising one or more service quality anomalies and a second component comprising one or more network-based events, correlating the first component and the second component to determine whether the one or more network-based events have an impact on service quality, and prioritizing a resolution of the network-based events that have an impact on service quality.

Abstract: A method includes collecting operational data from a system, segregating the data into a first component comprising one or more service quality anomalies and a second component comprising one or more network-based events, correlating the first component and the second component to determine whether the one or more network-based events have an impact on service quality, and prioritizing a resolution of the network-based events that have an impact on service quality.

Abstract: A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.

Abstract: Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.

Abstract: A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.

Abstract: Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.

Abstract: Methods and apparatus to assess current aspects of Quality Control useful for release of radioactive compounds for imaging, such as PET tracers as injectables, in an automated manner, without user interference, and in compliance with regulatory guidelines. The present method and system relates to an integrated automated quality control analysis of a substance utilizing a single sample injection for a plurality of inline quality control tests. A quantitative analysis of the sample via the plurality of quality control tests is conducted. A measurement value of each of the plurality of quality control parameters is determined and a comparison of each measurement value of the plurality of quality control parameters with a predetermined corresponding criterion value is made. A cumulative quality rating for the sample is determined and the validated sample is released based on the quality rating.

Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

Abstract: Methods and apparatus for facilitating the synthesis of compounds in a batch device are presented. Application of the batch type microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the selective introduction of multiple reagents via an enhanced rotary flow distribution valve through a single inlet port of the synthetic device. The sequential introduction of multiple reagents through a single inlet port allows an optimal delivery of highly concentrated reagents into the reactor and facilitates the synthesis of the desired products with a minimal loss of materials during transfers, which is critical to the synthesis of radiolabeled biomarkers.

Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.

Abstract: An apparatus and method for chemical synthesis, the method includes accessing a recipe, the recipe including a sequence of one or more processing steps for the chemical synthesis. The processing steps including one or more steps. The recipe is executed by sorting the processing steps and executing the one or more selected steps prior to executing other steps. The chemical synthesis is monitored by providing status data, indicating a status of the execution and enabling input of control data to modify execution based on the status data or user-initiated modification. Information related to the status of the execution is displayed, typically as a graphical representation of a process action.

Abstract: Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.

Abstract: Methods and apparatus for facilitating the synthesis of compounds in a nonflow-through device are presented. Application of the nonflow-through methods and microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the introduction of a pressurized gas through a tangential slit into a vortex reactor of the nonflow-through device, while one or more liquids are delivered to the reaction chamber through the same or different inlet ports. The introduction of the pressurized gas produces a cyclonic motion of the mixture within the reactor. Such a mechanism may be used to facilitate the evaporation of various liquids within the reactor at lower temperatures, thus reducing the production of unwanted byproducts that are associated with the use of high temperatures. In addition, thorough mixing of various liquids may be effected rapidly while allowing chemical reactions to take place efficiently within the vortex reactor.