Patents by Inventor Edward Botchwey

Edward Botchwey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF INCREASING MESENCHYMAL STROMAL CELL BIOSYNTHESIS OF SPECIALIZED PRO-RESOLVING MEDIATORS AND METHODS OF USE
    Publication number: 20260061008
    Abstract: Methods of stimulating production of specialized pro-resolving mediators (SPMs) by mesenchymal stem cells (MSCs) are provided. The methods include contacting MSCs with one or more SPM fatty acid precursors, SPM intermediates, or a combination of two or more thereof. Also provided are compositions including the stimulated MSCs or conditioned media from the stimulated MSCs. Methods of treating or inhibiting inflammation are also provided, including administering to a subject stimulated MSCs or conditioned media from stimulated MSCs.
    Type: Application
    Filed: August 24, 2023
    Publication date: March 5, 2026
    Applicants: University of Oregon, Georgia Tech Research Corporation
    Inventors: Nick Willett, Elaine deLorimier, Edward Botchwey, Thomas Turner
  • HYDROGELS COMPRISING CELL ADHESIVE PEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20240376438
    Abstract: The present disclosure relates to a hydrogel biomaterial comprising cell adhesive peptides to generate in vivo tumor models.
    Type: Application
    Filed: August 26, 2022
    Publication date: November 14, 2024
    Inventors: Susan Napier THOMAS, Edward BOTCHWEY, Andres J. GARCIA, Meghan O'MELIA
  • UNIAXIALLY-ALIGNED NANOFIBER SCAFFOLDS AND METHODS FOR PRODUCING AND USING SAME
    Publication number: 20210001010
    Abstract: Oral cavity wound healing occurs in an environment that sustains ongoing physical trauma and is rich in bacteria. Patients undergoing cleft palate repair have a high degree of wound healing complications, such as oronasal fistula (ONF) formation. Following hard palate injury, ONF was created that demonstrated little change in pro-regenerative monocytes LY6Clo monocytes; however, there were increased M2 macrophages observed. Delivery of FTY720 nanofiber scaffolds following hard palate injury prevented ONF formation, allowed complete wound healing and was associated with increased LY6Clo monocytes and pro-regenerative M2 macrophages. Evaluation of interleukin gene expression revealed reduction in pro-inflammatory IL1 and IL6 and increased expression of pro-regenerative IL10 with FTY720 nanofiber delivery.
    Type: Application
    Filed: February 3, 2020
    Publication date: January 7, 2021
    Inventors: Steven L. Goudy, Edward Botchwey
  • Degradable Microparticles for Protein and Small Molecule Delivery
    Publication number: 20180133148
    Abstract: The invention relates to a microparticle platform and pharmaceutical compositions capable of recruiting pro-regenerative cells to and/or reducing inflammation at the site of muscle, joint, tendon, and/or ligament damage. The invention further relates to methods of treating muscle, joint, tendon, and/or ligament damage comprising administering the microparticles or pharmaceutical compositions comprising the microparticles.
    Type: Application
    Filed: October 12, 2017
    Publication date: May 17, 2018
    Inventors: Liane Elizabeth Tellier, Edward Botchwey, Alexandra Ann Falis, Johnna Sue Temenoff
  • Biocompatible, biodegradable polymer-based, lighter than or light as water scaffolds for tissue engineering and methods for preparation and use thereof
    Patent number: 8137972
    Abstract: Scaffolds for tissue engineering prepared from biocompatible, biodegradable polymer-based, lighter than or light as water microcarriers and designed for cell culturing in vitro in a rotating bioreactor are provided. Methods for preparation and use of these scaffolds as tissue engineering devices are also provided.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: March 20, 2012
    Assignees: Drexel University, The Wistar Institute, The Trustees Of The University of Pennsylvania
    Inventors: Cato T. Laurencin, Solomon R. Pollack, Elliot Levine, Edward Botchwey, Helen H. Lu, Mohammed Yusuf Khan
  • Biocompatible, biodegradable polymer-based, lighter than or light as water scaffolds for tissue engineering and methods for preparation and use thereof
    Publication number: 20070231900
    Abstract: Scaffolds for tissue engineering prepared from biocompatible, biodegradable polymer-based, lighter than or light as water microcarriers and designed for cell culturing in vitro in a rotating bioreactor are provided. Methods for preparation and use of these scaffolds as tissue engineering devices are also provided.
    Type: Application
    Filed: May 30, 2007
    Publication date: October 4, 2007
    Inventors: Cato Laurencin, Solomon Pollack, Elliot Levine, Edward Botchwey, Helen Lu, Mohammed Khan
  • Biocompatible, biodegradable polymer-based, lighter than or light as water scaffolds for tissue engineering and methods for preparation and use thereof
    Publication number: 20020155559
    Abstract: Scaffolds for tissue engineering prepared from biocompatible, biodegradable polymer-based, lighter than or light as water microcarriers and designed for cell culturing in vitro in a rotating bioreactor are provided. Methods for preparation and use of these scaffolds as tissue engineering devices are also provided.
    Type: Application
    Filed: January 17, 2002
    Publication date: October 24, 2002
    Inventors: Cato T. Laurencin, Solomon R. Pollack, Elliot Levine, Edward Botchwey, Helen H. Lu, Mohammed Yusuf Khan