Patents by Inventor Edward Boyden

Edward Boyden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10882892
    Abstract: CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: January 5, 2021
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Publication number: 20200400677
    Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
    Type: Application
    Filed: June 22, 2020
    Publication date: December 24, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Edward BOYDEN, Adam Henry MARBLESTONE, Samuel Gordon RODRIQUES
  • Publication number: 20200348502
    Abstract: A light field microscope may record a raw light field video of a sample. The raw video recording may be decomposed into a non-negative low-rank component and a non-negative sparse component. The low-rank component may correspond to a static portion of the sample, and the sparse component may correspond to a dynamically changing portion of the sample. Volume reconstruction may be performed on the sparse component to generate a three-dimensional video of the sample, with improved spatial resolution. In some cases, the decomposition is calculated by an alternating direction method of multipliers algorithm, with the non-negativity of the sparse component and low-rank component enforced after each iteration. In some cases, the volume reconstruction is calculated by Richardson-Lucy iteration with regularization. The sample may be fluorescent. The fluorescence may be indicative of neural activity in the sample.
    Type: Application
    Filed: November 25, 2019
    Publication date: November 5, 2020
    Inventors: Young-Gyu Yoon, Zeguan Wang, Nikita Pak, Edward Boyden
  • Publication number: 20200291074
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: May 28, 2020
    Publication date: September 17, 2020
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan KLAPOETKE, Brian Yichiun CHOW, Edward BOYDEN, Gane KA-Shu WONG, Yongku Peter CHO
  • Patent number: 10758175
    Abstract: A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: September 1, 2020
    Assignees: Massachusetts Institute of Technology, NuVu LLC
    Inventors: Nir Grossman, David Wang, Edward Boyden
  • Patent number: 10717769
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: July 21, 2020
    Assignees: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane KA-Shu Wong, Yongku Peter Cho
  • Patent number: 10711044
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: July 14, 2020
    Assignees: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Publication number: 20200031883
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: September 13, 2019
    Publication date: January 30, 2020
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Patent number: 10545145
    Abstract: The invention, in some aspects relates to compositions and methods for imaging biological systems and physiological activity and conditions in cells.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: January 28, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Or Shemesh, Asmamaw Wassie, Chih-Chieh Yu, Edward Boyden
  • Publication number: 20200008743
    Abstract: A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.
    Type: Application
    Filed: September 16, 2019
    Publication date: January 9, 2020
    Inventors: Nir Grossman, David Wang, Edward Boyden
  • Patent number: 10520715
    Abstract: The information budget of a light field microscope is increased by increasing the field of view and image circle diameter of the microscope, while keeping the ratio of overall magnification of the microscope to the numerical aperture of the microscope unchanged. Alternatively, the information budget is increased by increasing the field of view and image circle diameter of the microscope by a first factor, while increasing the ratio of overall magnification of the microscope to the numerical aperture of the microscope by a smaller, second factor. In some cases, an infinity-corrected light field microscope has an overall magnification that is greater than the nominal magnification of the objective lens.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: December 31, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Moshe Ben Ezra, Edward Boyden, Christopher Rowlands, Young Gyu Yoon
  • Publication number: 20190388705
    Abstract: Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing an NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell.
    Type: Application
    Filed: June 21, 2019
    Publication date: December 26, 2019
    Inventors: Karl Deisseroth, Feng Zhang, Edward Boyden
  • Patent number: 10514534
    Abstract: The information budget of a light field microscope is increased by increasing the field of view and image circle diameter of the microscope, while keeping the ratio of overall magnification of the microscope to the numerical aperture of the microscope unchanged. Alternatively, the information budget is increased by increasing the field of view and image circle diameter of the microscope by a first factor, while increasing the ratio of overall magnification of the microscope to the numerical aperture of the microscope by a smaller, second factor. In some cases, an infinity-corrected light field microscope has an overall magnification that is greater than the nominal magnification of the objective lens.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: December 24, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Moshe Ben Ezra, Edward Boyden, Christopher Rowlands, Young Gyu Yoon
  • Publication number: 20190352347
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: August 2, 2019
    Publication date: November 21, 2019
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan KLAPOETKE, Brian Yichiun CHOW, Edward BOYDEN, Gane KA-Shu WONG, Yongku Peter CHO
  • Patent number: 10472398
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: November 12, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Patent number: 10472399
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: November 12, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Patent number: 10448883
    Abstract: A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: October 22, 2019
    Assignees: Massachusetts Institute of Technology, NuVu LLC
    Inventors: Nir Grossman, David Wang, Edward Boyden
  • Publication number: 20190307882
    Abstract: The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to target opsins to the soma of cells in which they are expressed. Compositions of the invention may be delivered to cells and subjects and used in methods to modulate electrical activity of cells in which they are expressed, and for treatment of diseases and conditions in subjects.
    Type: Application
    Filed: June 3, 2017
    Publication date: October 10, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Or A. SHEMESH, Changyang LINGHU, Edward BOYDEN
  • Publication number: 20190290786
    Abstract: The invention, in some aspects, relates to dummy-fluorescent (DF) polypeptide molecules and their encoding nucleic acid molecules and use of such molecules in fusion proteins and their encoding nucleic acid molecules. Compositions of the invention may be delivered to cells and subjects and used in methods to modulate electrical activity of cells in which they are expressed, and for treatment of diseases and conditions in subjects.
    Type: Application
    Filed: July 20, 2017
    Publication date: September 26, 2019
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Aimei YANG, Demian PARK, Kiryl PIATKEVICH, Edward BOYDEN
  • Patent number: 10392426
    Abstract: The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: August 27, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of the University of Alberta, President and Fellows of Harvard College
    Inventors: Nathan Klapoetke, Edward Boyden, Yongku Cho, Brian Y. Chow, Gane K. S. Wong, Adam E. Cohen, Daniel R. Hochbaum