Patents by Inventor Edward Boyden

Edward Boyden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240264163
    Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
    Type: Application
    Filed: January 17, 2024
    Publication date: August 8, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Edward BOYDEN, Adam Henry MARBLESTONE, Samuel Gordon RODRIQUES
  • Patent number: 11906525
    Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: February 20, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Edward Boyden, Adam Henry Marblestone, Samuel Gordon Rodriques
  • Patent number: 11759634
    Abstract: In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.
    Type: Grant
    Filed: January 1, 2021
    Date of Patent: September 19, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Nir Grossman, David Bono, Edward Boyden
  • Publication number: 20230111776
    Abstract: Systems and methods of the present disclosure are directed to neural stimulation via non-invasive sensory stimulation. Non-invasive sensory stimulations can comprise audio stimulation, visual stimulation, mechanical stimulation, or a combination thereof. The combination and/or sequence of one or more of audio, visual, and mechanical brain stimulations can adjust, control or otherwise manage the frequency of the neural oscillations to provide beneficial effects to one or more cognitive states or cognitive functions of the brain, while mitigating or preventing adverse consequences on a cognitive state or cognitive function that stems from, for example, sleep deprivation, stress, hormonal imbalance, or other physical, physiological, or psychological conditions. In doing so, the present systems and methods can improve the cognitive potential of a person.
    Type: Application
    Filed: September 26, 2022
    Publication date: April 13, 2023
    Inventors: Zach Malchano, Brent Vaughan, Martin Williams, Mihaly Hajos, Edward Boyden, Aylin Cimenser, Xiao Da
  • Publication number: 20230104621
    Abstract: The present disclosure describes a method for neuromodulating a subject, comprising providing (i) a cognitively engaging content, and (ii) a gamma oscillation inducing waveform, wherein said gamma oscillation inducing waveform: comprises an intensity that renders said gamma oscillation inducing waveform imperceptible to said subject; and causes a therapeutic improvement in a cognitive function, thereby neuromodulating said subject.
    Type: Application
    Filed: September 26, 2022
    Publication date: April 6, 2023
    Inventors: Zach Malchano, Brent Vaughan, Martin Williams, Mihaly Hajos, Edward Boyden, Aylin Cimenser, Xiao Da
  • Publication number: 20220291226
    Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
    Type: Application
    Filed: May 25, 2022
    Publication date: September 15, 2022
    Applicant: Massachusetts Institute of Technology
    Inventors: Edward BOYDEN, Adam Henry MARBLESTONE, Samuel Gordon RODRIQUES
  • Publication number: 20220169684
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Application
    Filed: February 10, 2022
    Publication date: June 2, 2022
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan KLAPOETKE, Brian Yichiun CHOW, Edward BOYDEN, Gane KA-Shu WONG, Yongku Peter CHO
  • Patent number: 11346842
    Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: May 31, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Edward Boyden, Adam Henry Marblestone, Samuel Gordon Rodriques
  • Patent number: 11324824
    Abstract: The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to target opsins to the soma of cells in which they are expressed. Compositions of the invention may be delivered to cells and subjects and used in methods to modulate electrical activity of cells in which they are expressed, and for treatment of diseases and conditions in subjects.
    Type: Grant
    Filed: June 3, 2017
    Date of Patent: May 10, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Or A. Shemesh, Changyang Linghu, Edward Boyden
  • Patent number: 11318278
    Abstract: A neuromodulator may output stimuli that causes a user to fall asleep faster than the user would in the absence of the stimuli. Alternatively, the stimuli may modify a sleep state or behavior associated with a sleep state, or may cause or hinder a transition from a waking state to a sleep state or from a sleep state to another sleep state. The neuromodulator may take electroencephalography measurements. Based on these measurements, the neuromodulator may detect, in real time, instantaneous amplitude and instantaneous phase of an endogenous brain signal. The neuromodulator may output stimulation that is, or that causes sensations which are, phase-locked with the endogenous brain signal. In the course of calculating instantaneous phase and amplitude, the neuromodulator may perform an endpoint-corrected Hilbert transform. The stimuli may comprise auditory, visual, electrical, magnetic, vibrotactile or haptic stimuli.
    Type: Grant
    Filed: December 22, 2018
    Date of Patent: May 3, 2022
    Assignees: Massachusetts Institute of Technology, Elemind Technologies, Inc.
    Inventors: Nir Grossman, David Wang, Edward Boyden
  • Patent number: 11278633
    Abstract: The invention, in some aspects, relates to dummy-fluorescent (DF) polypeptide molecules and their encoding nucleic acid molecules and use of such molecules in fusion proteins and their encoding nucleic acid molecules. Compositions of the invention may be delivered to cells and subjects and used in methods to modulate electrical activity of cells in which they are expressed, and for treatment of diseases and conditions in subjects.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: March 22, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Aimei Yang, Demian Park, Kiryl Piatkevich, Edward Boyden
  • Patent number: 11274128
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: March 15, 2022
    Assignees: Massachusetts Institute of Technology, The Governors of the University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Patent number: 11275079
    Abstract: Voltage reporter molecules and compositions, and methods for detecting voltage and voltage change in cells are provided. Also provided are methods for delivery, expression, and use of the voltage reporter molecules in cells, tissues, and subjects.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: March 15, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Edward Boyden, Kiryl Piatkevich, Eunjung Jung
  • Publication number: 20210348217
    Abstract: The invention, in some aspects, includes systems, methods and components of molecular recorders that encode the timing of transcriptional activity into the sequence of RNA, which can then enable a sequencing-based readout of the internal dynamics of cells.
    Type: Application
    Filed: July 16, 2019
    Publication date: November 11, 2021
    Inventors: Samuel Gordon RODRIQUES, Edward BOYDEN, Fei CHEN, Linlin CHEN, Sophia LIU, Ellen ZHONG, Joseph SCHERRER
  • Patent number: 11166632
    Abstract: A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: November 9, 2021
    Assignees: Massachusetts Institute of Technology, Elemind Technologies, Inc.
    Inventors: Nir Grossman, David Wang, Edward Boyden
  • Patent number: 11007374
    Abstract: Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing an NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events occurring in the cell. Light is provided to the cell to activate the expressed NpHR ion pump, thereby decreasing the probability of depolarization events occurring in the cell.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: May 18, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Feng Zhang, Edward Boyden
  • Publication number: 20210121693
    Abstract: In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.
    Type: Application
    Filed: January 1, 2021
    Publication date: April 29, 2021
    Inventors: Nir Grossman, David Bono, Edward Boyden
  • Publication number: 20210059528
    Abstract: A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.
    Type: Application
    Filed: July 30, 2020
    Publication date: March 4, 2021
    Inventors: Nir Grossman, David Wang, Edward Boyden
  • Patent number: 10905878
    Abstract: In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: February 2, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Nir Grossman, David Bono, Edward Boyden
  • Patent number: 10882892
    Abstract: CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: January 5, 2021
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho