Patents by Inventor Edward Bradley

Edward Bradley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHYSICAL FACE CLONING
    Publication number: 20120185218
    Abstract: A computer-implemented method is provided for physical face cloning to generate a synthetic skin. Rather than attempt to reproduce the mechanical properties of biological tissue, an output-oriented approach is utilized that models the synthetic skin as an elastic material with isotropic and homogeneous properties (e.g., silicone rubber). The method includes capturing a plurality of expressive poses from a human subject and generating a computational model based on one or more material parameters of a material. In one embodiment, the computational model is a compressible neo-Hookean material model configured to simulate deformation behavior of the synthetic skin. The method further includes optimizing a shape geometry of the synthetic skin based on the computational model and the captured expressive poses. An optimization process is provided that varies the thickness of the synthetic skin based on a minimization of an elastic energy with respect to rest state positions of the synthetic skin.
    Type: Application
    Filed: October 18, 2011
    Publication date: July 19, 2012
    Applicant: DISNEY ENTERPRISES, INC.
    Inventors: Bernd Bickel, Peter Kaufmann, Bernhard Thomaszewski, Derek Edward Bradley, Philip John Jackson, Stephen R. Marschner, Wojciech Matusik, Markus Gross, Thabo Dominik Beeler
  • GPCR Agonists
    Publication number: 20120172358
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
    Type: Application
    Filed: February 14, 2012
    Publication date: July 5, 2012
    Applicant: Prosidion Limited
    Inventors: Stuart Edward Bradley, Matthew Colin Thor Fyfe, Lisa Sarah Bertram, William Gattrell, Revathy Perpetua Jeevaratnam, John Keily, Martin James Procter, Chrystelle Marie Rasamison, Philip John Rushworth, Colin Peter Sambrook-Smith, David French Stonehouse, Simon Andrew Swain, Geoffrey Martyn Williams
  • G-protein coupled receptor agonists
    Patent number: 8193359
    Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.
    Type: Grant
    Filed: December 23, 2005
    Date of Patent: June 5, 2012
    Assignee: Prosidion Limited
    Inventors: Matthew Colin Thor Fyfe, Gerard Hugh Thomas, Lisa Sarah Bertram, Stuart Edward Bradley, William Gattrell, Chrystelle Marie Rasamison, Vilasben Kanji Shah
  • Pyridine, pyrimidine and pyrazine derivatives as GPCR agonists
    Patent number: 8173807
    Abstract: Compounds of formula (I): R1-A-V—B—R2, wherein V is phenyl or a 6-membered heteroaryl ring containing up to three N-atoms, or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.
    Type: Grant
    Filed: December 30, 2005
    Date of Patent: May 8, 2012
    Assignee: Prosidion Limited
    Inventors: Stuart Edward Bradley, Matthew Colin Thor Fyfe, Gerard Hugh Thomas
  • Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
    Patent number: 8158622
    Abstract: Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: April 17, 2012
    Assignee: Prosidion Limited
    Inventors: Stuart Edward Bradley, Thomas Martin Krulle, Peter John Murray, Martin James Procter, Robert John Rowley, Colin Peter Sambrook Smith, Gerard Hugh Thomas, Karen Lesley Schofield
  • Bicyclic aryl and heteroaryl receptor modulators
    Patent number: 8063247
    Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful inter alia for the treatment of obesity.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: November 22, 2011
    Assignee: Prosidion Limited
    Inventors: Jason Bloxham, Stuart Edward Bradley, Thomas Martin Krulle, Martin James Procter, Colin Peter Sambrook-Smith, Karen Lesley Schofield, Donald Smyth
  • Indole-2-carboxylic acid amides
    Publication number: 20110086885
    Abstract: Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
    Type: Application
    Filed: November 25, 2005
    Publication date: April 14, 2011
    Inventors: Stuart Edward Bradley, Thomas Martin Krulle, Gerard Hugh Thomas
  • Pyrrolopyridine-2-carboxylic acid hydrazides
    Patent number: 7884112
    Abstract: Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, or as cardioprotectants or inhibitors of abnormal cell growth.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: February 8, 2011
    Inventors: Stuart Edward Bradley, Revathy Perpetua Jeevaratnam, Thomas Martin Krulle, Martin James Procter, Robert John Rowley, Gerard Hugh Thomas, Ana Valdesabril
  • COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
    Publication number: 20100286112
    Abstract: The present invention is directed to therapeutic compounds which have dual activity as agonists of GPR119 and inhibitors of DPP-IV and are useful for the treatment of metabolic disorders including type II diabetes.
    Type: Application
    Filed: September 10, 2008
    Publication date: November 11, 2010
    Inventors: Oscar Barba, Stuart Edward Bradley, Matthew Colin Thor Fyfe, Patrick Eric Hanrahan, Thomas Martin Krulle, Martin James Procter, Christine Reynet McCormack, Karen Lesley Schofield, Donald Smyth, Alan John William Stewart, Simon Andrew Swain, Peter Widdowson
  • BICYCLIC ARYL AND HETEROARYL RECEPTOR MODULATORS
    Publication number: 20100267780
    Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful inter alia for the treatment of obesity.
    Type: Application
    Filed: September 8, 2008
    Publication date: October 21, 2010
    Inventors: Jason Bloxham, Stuart Edward Bradley, Thomas Martin Krulle, Colin Peter Sambrook-Smith, Karen Lesley Schofield, Donald Smyth
  • BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
    Publication number: 20100173886
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity.
    Type: Application
    Filed: May 22, 2008
    Publication date: July 8, 2010
    Inventors: Jason Bloxham, Stuart Edward Bradley, Tom Banksia Dupree, Peter Timothy Fry, Patrick Eric Hanrahan, Thomas Martin Krulle, Martin James Procter, Colin Peter Sambrook-Smith, Karen Lesley Schofield, Donald Smyth, Alan John Stewart
  • GENEMAP OF THE HUMAN GENES ASSOCIATED WITH SCHIZOPHRENIA
    Publication number: 20100144538
    Abstract: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to SCHIZOPHRENIA disease and/or their response to a particular drug or drugs.
    Type: Application
    Filed: March 10, 2008
    Publication date: June 10, 2010
    Inventors: Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquin, Helene Fournier, Pascal Croteau, Nouzha Paquin, Daniel Dubois, Vanessa Bruat, Paul Van Eerdewegh, Jonathan Segal, Randall David Little, Tim Keith
  • GENEMAP OF THE HUMAN GENES ASSOCIATED WITH PSORIASIS
    Publication number: 20100120627
    Abstract: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to psoriasis disease and/or their response to a particular drug or drugs.
    Type: Application
    Filed: August 2, 2006
    Publication date: May 13, 2010
    Inventors: Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquian, Quynh Nguyen-Huu, Pascal Croteau, Rene Allard, Randall David Little, Johanne Cousineau, Sophie Debrus, Tim Keith, Natali Henderson, Daniel Dubois, Paul Van Eerdewegh, Jonathan Segal
  • Genemap of the human genes associated with crohn's disease
    Publication number: 20100081129
    Abstract: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs.
    Type: Application
    Filed: May 1, 2006
    Publication date: April 1, 2010
    Inventors: Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquin, Hélene Fournier, Quynh Nguyen-Huu, Pascal Croteau, Réne Allard, Sophie Debrus, Valerie Serre, Paul Van Eerdewegh, Randall David Little, Jonathan Segal, Tim Keith
  • Pyridine, pyrimidine and pyrazine derivatives as gpcr agonists
    Publication number: 20100035897
    Abstract: Compounds of formula (I): R1-A-V—B—R2, wherein V is phenyl or a 6-membered heteroaryl ring containing up to three N-atoms, or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful for the treatment of obesity, and for the treatment of diabetes.
    Type: Application
    Filed: December 30, 2005
    Publication date: February 11, 2010
    Inventors: Stuart Edward Bradley, Matthew Colin Thor Fyfe, Gerard Hugh Thomas
  • GENEMAP OF THE HUMAN GENES ASSOCIATED WITH LONGEVITY
    Publication number: 20090305900
    Abstract: The present invention relates to the selection of a set of SNP markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's longevity, their protection against age-related diseases and/or their response to a particular drug or drugs.
    Type: Application
    Filed: June 19, 2006
    Publication date: December 10, 2009
    Inventors: Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquin, Quynh Nguyen-Huu, Pascal Croteau, Rene Allard, Johanne Cousineau, Nouzha Paquin, Paul Van Eerdewegh, Randall David Little, Tim Keith, Jonathan Segal
  • Gpcr Agonists
    Publication number: 20090221644
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
    Type: Application
    Filed: June 29, 2006
    Publication date: September 3, 2009
    Inventors: Stuart Edward Bradley, Matthew Colin Thor Fyfe, Lisa Sarah Bertram, William Gattrell, Martin James Procter, Chrystelle Marie Rasamison, Colin Peter Sambrook-Smith, Vilasben Kanji Shah, David French Stonehouse, Simon Andrew Swain, Gerard Hugh Thomas
  • G-protein Coupled Receptor Agonists
    Publication number: 20090203676
    Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
    Type: Application
    Filed: June 30, 2006
    Publication date: August 13, 2009
    Inventors: Oscar Barba, Stuart Edward Bradley, Matthew Colin Thor Fyfe, Lisa Sarah Bertram, William Gattrell, Martin James Procter, Chrystelle Marie Rasamison, Simon Andrew Swain
  • GENEMAP OF THE HUMAN GENES ASSOCIATED WITH CROHN'S DISEASE
    Publication number: 20090181380
    Abstract: The present invention relates to the selection of a set of polymorphism makers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to IBD (ex: Chrohn's disease) and/or their response to a particular drug or drugs.
    Type: Application
    Filed: December 19, 2006
    Publication date: July 16, 2009
    Inventors: Abdelmajid Belouchi, John Verner Raelson, Walter Edward Bradley, Bruno Paquin, Helene Fournier, Quynh Nguyen-Huu, Pascal Croteau, Rene Allard, Sandie Briand, Paul Van Eerdewegh, Randall David Little, Jonathan Segal, Tim Keith
  • Combination Therapies using Melengestrol Acetate and Zilpaterol or its Salts
    Publication number: 20090181906
    Abstract: This invention generally relates to a method for promoting growth and increasing feed utilization efficiency in animals, and, more specifically, to combinations comprising zilpaterol (and salts thereof) and melengestrol acetate. Included within this invention are treatment methods comprising the administration of such combinations to animals, compositions comprising such combinations, uses of such combinations to prepare medicaments, and kits for using such combinations.
    Type: Application
    Filed: December 4, 2008
    Publication date: July 16, 2009
    Applicant: Intervet International B.V.
    Inventors: Mary Irene Wray, Damon Edward Bradley, Melissa A. Petersen, Auddie Sharp, Celia Shelton, Jayden Lloyd Montgomery