Abstract: Paper supports for fluid or cells having a decreased surface area are provided. Methods of producing such support comprise contacting the support with a composition comprising sodium periodate such that the surface area is decreased. The support or a portion thereof are reduced in surface area and the reduced portion or reduced entire support is degradable. The resulting paper support may also have hydrophilic channels and/or hydrophobic barriers that are also reduced in surface area. In embodiments the support may be a micropad or support for producing a tissue have desired structure. The support is miniaturized dialdehyde paper support that is malleable and retains its structure.