Abstract: An aerosol-generating device (100) comprises a first power source (120), an aerosolizer (110) configured to receive power from the first power source and configured to generate aerosol from an aerosol-generating substrate (170), a second power source (130), and a heating circuit (160) configured to receive power from the second power source to heat the first power source.

Abstract: An aerosol-generating device is provided, including: a battery, and a heater configured to heat the battery, in which one or both of the battery and the heater are movably mounted in the aerosol-generating device, such that the battery and the heater are relatively movable towards each other between a near position and a distanced position, the near position being different from the distanced position. An aerosol-generating system including an aerosol-generating article and the aerosol-generating device, and a method for heating a battery in the aerosol-generating device, are also provided.

Abstract: An electronic device is provided, including: a battery, and a heater configured to heat the battery as a first heating function of the heater, the heater being further configured to perform a second heating function, the first heating function being different from the second heating function, the electronic device being configured to switch between the first and the second heating functions of the heater in dependence on a temperature of the battery, the electronic device being an aerosol-generating device, and in which heating an aerosol-forming substrate is the second heating function. An aerosol-generating system including an aerosol-generating article and the electronic device, and a method for operating the electronic device, are also provided.

Abstract: The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.

Abstract: The present disclosure provides long-acting formulations and vehicles, methods of making the same and methods of using the same.

Abstract: The present disclosure provides long-acting formulations of tenofovir alafenamide, methods of making the same and methods of using the same.

Abstract: The present disclosure provides a biodegradable drug delivery composition including a vehicle and an insoluble component comprising beneficial agent dispersed in the vehicle. In some cases, the composition includes sucrose acetate isobutyrate, biodegradable polymer, hydrophobic solvent, and a complex comprising a counterion and beneficial agent, such as protein, peptide, nucleic acid, or small molecular weight compound. Also provided, are kits including the biodegradable drug delivery composition or components thereof, as well as methods of making and using the biodegradable drug delivery composition.

Abstract: The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.

Abstract: The present disclosure provides a biodegradable drug delivery composition including a vehicle and an insoluble component comprising beneficial agent dispersed in the vehicle. Typically, the composition is not an emulsion, but has a low viscosity and further provides for minimized initial burst and sustained release of the beneficial agent over time. Also provided, are kits including the biodegradable drug delivery composition or components thereof, as well as methods of making and using the biodegradable drug delivery composition.

Abstract: Useful materials are produced from keratin containing raw materials by a process that includes gentle lanthionization of cystine disulfide bonds. Hydratable materials are produced for use in medical and cosmetic applications.

Abstract: Useful materials are produced from keratin containing raw materials by a process that includes gentle lanthionization of cystine disulfide bonds. Hydratable materials are produced for use in medical and cosmetic applications.