Abstract: Provided herein are novel in vitro biomimetic aerosol exposure systems designed to enhance the understanding of respiratory health impacts from aerosol inhalant devices, such as e-cigarettes. The systems and methods described herein improve biomimicry at multiple levels, including, system, macroscopic, and cellular levels, to provide more accurate and realistic exposure conditions. As described, these systems and methods address many limitations of existing smoking machines by offering better correlation between in vitro and in vivo conditions, improved particle deposition and dosimetry, and more realistic interactions between aerosols and biological samples. As various aspects, the biomimetic aerosol exposure system includes an emissions delivery system, an oral cavity module, a bifurcated exposure chamber, and a flow control subsystem.

Abstract: A size reduction apparatus and process for reducing the size of a heterogeneous or homogeneous article or articles using variable and interchangeable interior parts for varying article output size and an air handling system for introducing air and/or fluid into the process of size-reduction. The components of a heterogeneous article are separated and used to aid in the size-reduction process.