Abstract: Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity is increased.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases with alternative configurations. Also described are methods of making and using compositions comprising these linkers.

Abstract: The present invention leverages changes in the sensed strength of radio signals at different locations to determine a device's location. In one instance of the present invention, inference procedures are used to process ambient commercial radio signals, to estimate a location or a probability distribution over the locations of a device. In another instance of the present invention, a system utilizes learning and inference methods that are applied to rank vector of signal strength vectors. Moving to such rank orderings leads to systems that bypass consideration of absolute signal strengths in location calculations. The present invention facilitates approximations for locating a device by providing a system that does not require a substantial number of available ambient signal strengths while still providing useful location inferences in determining locations.

Abstract: A portable digital audio device is capable of playing a number of different data file types, such as music data files, speech data files, video data files, and the like. Different CODECs are generally used for different data types. The system determines the data file type and selects the appropriate CODEC based on the reported data file type. In addition, the reported data file type is used to select the appropriate media interface manager and appropriate user interface. The user interface, or “skin” is selected for compatibility with the media interface manager and selected CODEC. The appropriate controls are enabled and displayed for user operation. As new CODECs are added to the system, appropriate media interface managers and skins are also added to provide the necessary user interface compatibility.

Abstract: The present invention leverages changes in the sensed strength of radio signals at different locations to determine a device's location. In one instance of the invention, inference procedures are used to process ambient commercial radio signals, to estimate a location or a probability distribution over the locations of a device. In an instance of the invention, learning and inference methods are applied to rank vector of signal strength vectors. Moving to such rank orderings leads to methods that bypass consideration of absolute signal strengths in location calculations. The invention facilitates approximations for locating a device by providing a method that does not require a substantial number of available ambient signal strengths while still providing useful location inferences in determining locations.

Abstract: The present invention employs approximate device locations determined from changes in the sensed strength of radio signals at different locations. In one instance of the invention, the approximate device locations are based on inference procedures that are used to process ambient commercial radio signals, to estimate a location or a probability distribution over the locations of a device. In another instance of the invention, approximate device locations derived from learning and inference methods that are applied to rank vector of signal strength vectors are utilized. Moving to such rank orderings leads to methods that bypass consideration of absolute signal strengths in location calculations. The invention utilizes approximations for a device location that is based on a method that does not require a substantial number of available ambient signal strengths while still providing useful location inferences in determining locations.

Abstract: A method for expelling air out of mailpieces includes the steps of creating a stack of the mailpieces; cutting an opening in at least some of the mailpieces; jogging the stack of mailpieces; and subjecting the stack of mailpieces to at least one compression/decompression cycle during the jogging step thereby expelling air out of the at least some of the mailpieces through their corresponding openings.

Abstract: A self-adjusting moistening system for a mailing system is provided. The applicator is coupled to a float mechanism, placed in the reservoir of moistening fluid, by a spring. When the reservoir is full of moistening fluid, the spring is compressed, and therefore does not provide any force on the applicator. As the level of moistening fluid decreases, the height of the float mechanism in the reservoir will also decrease, thereby causing the spring to elongate. As the spring elongates, it will pull down on the applicator, thereby causing an increase in the force applied between the applicator and the wick. This increase in force provides a more uniform deposition of the moistening fluid to the envelope flap as the level of the moistening fluid in the reservoir varies from full to empty.

Abstract: A self-adjusting moistening system for a mailing system is provided. The applicator is coupled to a float mechanism, placed in the reservoir of moistening fluid, by a spring. When the reservoir is full of moistening fluid, the spring is compressed, and therefore does not provide any force on the applicator. As the level of moistening fluid decreases, the height of the float mechanism in the reservoir will also decrease, thereby causing the spring to elongate. As the spring elongates, it will pull down on the applicator, thereby causing an increase in the force applied between the applicator and the wick. This increase in force provides a more uniform deposition of the moistening fluid to the envelope flap as the level of the moistening fluid in the reservoir varies from full to empty.

Abstract: A portion or component of a metal container is provided with markings or indicia using laser light. High-speed laser steering is used to position laser light or laser light pulses across a lateral and longitudinal extent in a relatively short time period such as a time period selected so as to avoid slowing, stopping or otherwise interfering with other container or container component production processes. Preferably, tab stock for container-opening tabs can be provided with 6 to 9 or more visible characters within a time window of 50 to 100 milliseconds or less. Preferably, the size and resolution provided by the pulses are sufficient to permit legible, and preferably attractive, formation of any standard typewriter characters. In one embodiment, other logos, designs, textures, backgrounds and similar features can be provided.

Abstract: A method for expelling air out of mailpieces includes the steps of creating a stack of the mailpieces; cutting an opening in at least some of the mailpieces; jogging the stack of mailpieces; and subjecting the stack of mailpieces to at least one compression/decompression cycle during the jogging step thereby expelling air out of the at least some of the mailpieces through their corresponding openings. A jogger system incorporates the structure for accomplishing the method.

Abstract: A method for expelling air out of mailpieces includes the steps of creating a stack of the mailpieces; cutting an opening in at least some of the mailpieces; jogging the stack of mailpieces; and subjecting the stack of mailpieces to at least one compression/decompression cycle during the jogging step thereby expelling air out of the at least some of the mailpieces through their corresponding openings.

Abstract: A method for expelling air out of mailpieces includes the steps of creating a stack of the mailpieces; cutting in at least some of the mailpieces; jogging the stack of mailpieces; and subjecting the stack of mailpieces to at least one compression/decompression cycle during the jogging step thereby expelling air out of the at least some of the mailpieces through their corresponding openings. A jogger system incorporates the structure for accomplishing the method.

Abstract: A computer system employs electrically lossy transmission systems to dissipate RF energy, and thus reduce RF emissions near the source. An electrically lossy dielectric includes a colloidal dispersion of lossy material, e.g., graphite, in a polymer matrix. A layer of this material can be placed in contact with a conductor or with its surrounding dielectric. A metal layer contacts the other side of the lossy dielectric so that an electrically lossy transmission system is defined. Such transmission systems are defined with respect to signal conductors, shields for coaxial cables, PCB boards, and structural metal, such as heat sinks and vent openings, etc. In some cases, impedance mismatches are used to reflect unwanted energy back through or back and forth through the lossy transmission system. The lossy transmission systems dissipate RF energy so that there is less RF energy to radiate to the computer's exterior.

Abstract: A portion or component of a metal container is provided with markings or indicia using laser light. High-speed laser steering is used to position laser light or laser light pulses across a lateral and longitudinal extent in a relatively short time period such as a time period selected so as to avoid slowing, stopping or otherwise interfering with other container or container component production processes. Preferably, tab stock for container-opening tabs can be provided with 6 to 9 or more visible characters within a time window of 50 to 100 milliseconds or less. Preferably, the size and resolution provided by the pulses are sufficient to permit legible, and preferably attractive, formation of any standard typewriter characters. In one embodiment, other logos, designs, textures, backgrounds and similar features can be provided.

Abstract: A portion or component of a metal container is provided with markings or indicia using laser light. High-speed laser steering is used to position laser light or laser light pulses across a lateral and longitudinal extent in a relatively short time period such as a time period selected so as to avoid slowing, stopping or otherwise interfering with other container or container component production processes. Preferably, tab stock for container-opening tabs can be provided with 6 to 9 or more visible characters within a time window of 50 to 100 milliseconds or less. Preferably, the size and resolution provided by the pulses are sufficient to permit legible, and preferably attractive, formation of any standard typewriter characters. In one embodiment, other logos, designs, textures, backgrounds and similar features can be provided.

Abstract: A portion or component of a metal container is provided with markings or indicia using laser light. High-speed laser steering is used to position laser light or laser light pulses across a lateral and longitudinal extent in a relatively short time period such as a time period selected so as to avoid slowing, stopping or otherwise interfering with other container or container component production processes. Preferably, tab stock for container-opening tabs can be provided with 6 to 9 or more visible characters within a time window of 50 to 100 milliseconds or less. Preferably, the size and resolution provided by the pulses are sufficient to permit legible, and preferably attractive, formation of any standard typewriter characters. In one embodiment, other logos, designs, textures, backgrounds and similar features can be provided.

Abstract: A portion or component of a metal container is provided with markings or indicia using laser light. High-speed laser steering is used to position laser light or laser light pulses across a lateral and longitudinal extent in a relatively short time period such as a time period selected so as to avoid slowing, stopping or otherwise interfering with other container or container component production processes. Preferably, tab stock for container-opening tabs can be provided with 6 to 9 or more visible characters within a time window of 50 to 100 milliseconds or less. Preferably, the size and resolution provided by the pulses are sufficient to permit legible, and preferably attractive, formation of any standard typewriter characters. In one embodiment, other logos, designs, textures, backgrounds and similar features can be provided.

Abstract: A portion or component of a metal container is provided with markings or indicia using laser light. High-speed laser steering is used to position laser light or laser light pulses across a lateral and longitudinal extent in a relatively short time period such as a time period selected so as to avoid slowing, stopping or otherwise interfering with other container or container component production processes. Preferably, tab stock for container-opening tabs can be provided with 6 to 9 or more visible characters within a time window of 50 to 100 milliseconds or less. Preferably, the size and resolution provided by the pulses are sufficient to permit legible, and preferably attractive, formation of any standard typewriter characters. In one embodiment, other logos, designs, textures, backgrounds and similar features can be provided.