Patents by Inventor Edward C. Taylor

Edward C. Taylor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6066639
    Abstract: Glutamic acid derivatives in which the amino group is substituted with a 2-amino-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylalkyl-Z-carbonyl group, in which Z is a divalent, five-membered, nitrogen-containing heterocyclic ring system optionally containing a sulfur or nitrogen atom as a second hetero ring member, are antineoplastic agents. A typical embodiment is N-{3-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]-pyrazol-5-ylcarbonyl}-L-glutamic acid.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: May 23, 2000
    Assignees: The Trustees of Princeton University, Eli Lilly and Company
    Inventors: Edward C. Taylor, Chuan Shih, Koo Lee, Lynn S. Gossett
  • Patent number: 5873528
    Abstract: A nozzle assembly (11) of an adhesive dispensing valve (10) includes a first valve (32) adjacent a discharge orifice (34). The first valve (32) opens to permit the flow of adhesive therethrough and closes to terminate the flow of adhesive in response to respective first and second states of the valve operating module (14). The adhesive dispensing valve (10) has a separable nozzle plate (102) that includes the first valve seat (100) and the discharge orifice (34) and is coupled to a nozzle body (72) with a mounting cap (104). A secondary valve (146) is located upstream of the first valve (32) and permits adhesive to flow therethrough in response to both of the first and second states of the valve operating module. However, as the mounting cap (104) and nozzle plate (102) are removed, the secondary valve (146) automatically engages its valve seat (94), thereby terminating the flow of adhesive while the nozzle plate (102) is removed from the valve body (16).
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: February 23, 1999
    Assignee: Nordson Corporation
    Inventors: William A. Lewis, Edward C. Taylor
  • Patent number: 5786358
    Abstract: 2-Amino-4-hydroxy-4,5,6,7-tetrahydropyrido?2,3-d!pyrimidine derivatives of aromatic amides, such as a benzamide or thienylcarboxamide in which the amino portion of the amide is other than L-glutamic acid are inhibitors of enzymes which utilize folic acid, in particular glycinamide ribonucleotide formyl transferase. A typical embodiment is N-(N-{4-?2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido?2,3-d!pyrimidin-6-y l)ethyl!benzoyl}-L-.gamma.-glutamyl)-D-aspartic acid.
    Type: Grant
    Filed: September 4, 1996
    Date of Patent: July 28, 1998
    Assignee: The Trustees of Princeton University
    Inventors: Chuan Shih, Lynn S. Gossett, William J. Gill, Edward C. Taylor, James T. Metz
  • Patent number: 5667933
    Abstract: There are described heat-developable photosensitive image-recording elements which have an alkali-generating system incorporated therein. In the alkali-generating system, a slightly water-soluble metal compound is reacted with a salt of 2-hydroxy-pyridine-N-oxide, or its derivatives, in the presence of a fluid such as water, to form an insoluble precipitate and the alkali required for silver image development during processing. The image-recording materials are useful as image-forming materials in thermographic and photothermographic processes.
    Type: Grant
    Filed: November 20, 1996
    Date of Patent: September 16, 1997
    Assignee: Polaroid Corporation
    Inventors: Gary E. Cargill, Edward C. Taylor, Peter Viski, Christopher E. R. Orvig
  • Patent number: 5598974
    Abstract: A nozzle assembly (11) of an adhesive dispensing valve (10) includes a first valve (32) adjacent a discharge orifice (34). The first valve (32) opens to permit the flow of adhesive therethrough and closes to terminate the flow of adhesive in response to respective first and second states of the valve operating module (14). The adhesive dispensing valve (10) has a separable nozzle plate (102) that includes the first valve seat (100) and the discharge orifice (34) and is coupled to a nozzle body (72) with a mounting cap (104). A secondary valve (146) is located upstream of the first valve (32) and permits adhesive to flow therethrough in response to both of the first and second states of the valve operating module. However, as the mounting cap (104) and nozzle plate (102) are removed, the secondary valve (146) automatically engages its valve seat (94), thereby terminating the flow of adhesive while the nozzle plate (102) is removed from the valve body (16).
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: February 4, 1997
    Assignee: Nordson Corporation
    Inventors: William A. Lewis, Edward C. Taylor
  • Patent number: 5473071
    Abstract: Pyrido[2,3-d]pyrimidine compounds are prepared through the reaction of 2,4-diamino-6(1H)-pyrimidone and an activated derivative of a dialdehyde. A typical embodiment utilizes the dinitrile.
    Type: Grant
    Filed: November 6, 1989
    Date of Patent: December 5, 1995
    Assignee: Trustees of Princeton University
    Inventors: Edward C. Taylor, Philip M. Harrington
  • Patent number: 5344932
    Abstract: N-(Acyl)glutamic acid derivatives in which the acyl group is substituted with 4-hydroxypyrrolo[2,3-d]-pyrimidin-3-yl group are antineoplastic agents. A typical embodiment is N-[4-(2-{4-hydroxy-6-aminopyrrolo-[2,3-d]pyrimidin-3-yl}ethyl)benzoyl]-L-g lutamic acid.
    Type: Grant
    Filed: March 22, 1991
    Date of Patent: September 6, 1994
    Assignee: Trustees of Princeton University
    Inventor: Edward C. Taylor
  • Patent number: 5254687
    Abstract: 5-Substituted pyrrolo[2,3-d]pyrimidines are prepared from a nucleophile of the formula R.sup.2 -C(.dbd.NH)NH.sub.2 and a 2-amino-5-substituted-furan carrying a cyano or carboxy group in the 4-position. A typical example is the preparation of ethyl 4-(2-(2,4-diaminopyrrolo[2,3-d]pyrimidin-5-yl)ethyl}benzoate, an intermediate for the preparation of the known N-[4-{2-(2,4-diaminopyrrolo[2,3-d]pyrimidin-5-yl)ethyl}benzoyl]-L-glutamic acid, by allowing guanidine and ethyl 4-[2-(2-amino-3-cyanofur-4-yl)ethyl]benzoate to react under mild conditions.
    Type: Grant
    Filed: December 4, 1991
    Date of Patent: October 19, 1993
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, Hemantkumar H. Patel
  • Patent number: 5248775
    Abstract: 3-Ethynylpyrrolo[2,3-d]pyrimidines are chemical intermediates for antineoplastic N-(acyl)glutamic acid derivatives. A typical embodiment is 3-ethynyl-4-hydroxy-6-pivaloylaminopyrrolo[2,3-d]pyrimidine.
    Type: Grant
    Filed: January 31, 1992
    Date of Patent: September 28, 1993
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, Dietmar G. Kuhnt, Chuan Shih, Gerald B. Grindey
  • Patent number: 5028608
    Abstract: N-(Acyl)glutamic acid derivatives in which the acyl group is substituted with 4-hydroxypyrrolo[2,3-d]-pyrimidin-3-yl group are antineoplastic agents. A typical embodiment is N-{5-[2-(4-hydroxy-6-aminopyrrolo[2,3-d]pyrimidin-3-yl)ethyl]thien-2-ylcar bonyl}-L-glutamic acid.
    Type: Grant
    Filed: May 24, 1990
    Date of Patent: July 2, 1991
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, Dietmar G. Kuhnt, Chuan Shih, Gerald B. Grindey
  • Patent number: 5026851
    Abstract: 2,4-Diamino- and 2-amino-4-hydroxy- derivatives of N-(4-[2-(pyrido[2,3-d]pyrimidin-6-yl)alkyl]benzoyl-)-L-glutamic acids, and the corresponding 5,6,7,8-tetrahydro compounds are antineoplastic agents.The compounds are prepared by hydrolytic or hydrogenolytic removal of carboxylic acid protecting groups from the correspondingly protected glutamic acid derivatives.A typical embodiment is N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: June 25, 1991
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, Peter J. Harrington, Stephen R. Fletcher
  • Patent number: 5013738
    Abstract: Substituted pyrimidin-5-yl derivatives of L-glutamic acid are anti-neoplastic agents. A typical embodiment is N-{4-[6-(2,6-diamino-4-hydroxypyrimidin-5-yl)hex-1-en-3-yl]benzoyl}-L-glut amic acid.
    Type: Grant
    Filed: April 18, 1990
    Date of Patent: May 7, 1991
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, Thomas H. Schrader, Loren D. Walensky
  • Patent number: 4996206
    Abstract: N-(Acyl)glutamic acid derivatives in which the acyl group is substituted with 4-hydroxypyrrolo[2,3-d]pyrimidin-3-yl group are antineoplastic agents. A typical embodiment is N-[4-(2-{4-hydroxypyrrolo[2,3-d]pyrimidin-3-yl}ethyl)benzoyl]-L-glutamic acid.
    Type: Grant
    Filed: May 24, 1990
    Date of Patent: February 26, 1991
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, Dietmar G. Kuhnt, Chuan Shih, Gerald B. Grindey
  • Patent number: 4988813
    Abstract: 2-Amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-en-1-yl]pyrido[2,3,-d]pyrimid ines and 2-amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-yn-1-yl]pyrido[2,3-d]pyrimid ines are prepared through through the reaction of a haloaromatic compound and an unsaturated compound in the presence of a palladium catalyst. The products are chemical intermediates for the preparation of antineoplastic agents.A typical embodiment is the reaction of a protected 2-amino-4-hydroxy-6-ethynylpyrido[2,3-d]pyrimidine and an ester of 4-iodobenzoic acid.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: January 29, 1991
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George S. K. Wong
  • Patent number: 4927828
    Abstract: The diastereoisomeric forms of N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]-pyrimidin-6-yl) ethyl]benzoyl)-L-glutamic acid are antineoplastic agents.The compounds are prepared by separation of the diastereoisomeric form of the correspondingly protected glutamic derivatives and hydrolytic or hydrogenolytic removal of carboxylic acid and/or amino protecting groups.Typical embodiments are the (R,S) and (S,S) forms of N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: June 28, 1988
    Date of Patent: May 22, 1990
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George P. Beardsley, Chuan Shih, Stephen R. Fletcher
  • Patent number: 4920125
    Abstract: Pyrimidin-5-yl derivatives of L-glutamic acid are anti-neoplastic agents. A typical embodiment is N-(4-[5-(2,6-diamino-4-hydroxypyrimidin-5-yl)-butyl]-thien-2-ylcarboxy)-L- glutamic acid.
    Type: Grant
    Filed: August 29, 1989
    Date of Patent: April 24, 1990
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, Philip M. Harrington, Chuan Shih
  • Patent number: 4902796
    Abstract: 2-Amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-en-1-yl]pyrido[2,3,-d]pyrimid ines and 2-amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-yn-1-yl]pyrido[2,3-d]pyrimid ines are prepared through the reaction of a halo-aromatic compound and an unsaturated compound in the prosence of a palladium catalyst. The products are chemical intermediates for the preparation of antineo-plastic agents.A typical embodiment is the reaction of a protected 2-amino-4-hydroxy-6-ethynylpyrido[2,3-d]pyrimidine and an ester of 4-iodobenzoic acid.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: February 20, 1990
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, George S. K. Wong
  • Patent number: 4895946
    Abstract: Pyrido[2,3-d]pyrimidine compounds are prepared through the reaction of 2,4-diamino-6(1H)-pyrimidone and an activated derivative of a dialdehyde. A typical embodiment utilizes the dinitrile.
    Type: Grant
    Filed: April 25, 1988
    Date of Patent: January 23, 1990
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, Philip M. Harrington
  • Patent number: 4889859
    Abstract: Derivatives of N-[2-(5,6,7,8-tetrahydropyrido-[2,3-d]pyrimidin-6-yl)-alkyl]benzoyl-L-glut amic acid are antineoplastic agents. A typical embodiment is N-(2-fluoro-4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido-[2,3-d]pyrimi din-6-yl)ethyl]benzoyl)-L-glutamic acid.
    Type: Grant
    Filed: February 5, 1988
    Date of Patent: December 26, 1989
    Assignee: The Trustees of Princeton University
    Inventors: Edward C. Taylor, Chuan Shih
  • Patent number: D366051
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: January 9, 1996
    Assignee: Nordson Corporation
    Inventors: William A. Lewis, Edward C. Taylor