Abstract: Systems and methods for an ex vivo tissue perfusion apparatus are provided. In certain embodiments, the disclosed subject matter includes a container to store ex vivo tissue, a plurality of tubes containing a perfusate, and a pump which cycles the perfusate through the ex vivo tissue. The perfusion apparatus can be configured for mobility and can be transported to active emergency situations in order to perform mobile perfusion of ex vivo tissues. In certain embodiments, the discloses subject matter contemplates a method for performing mobile profusion of ex vivo tissue in emergency situations, for example, active warzones. In certain embodiments, the profusion apparatus can be used as part of a method of training for doctors in the reattachment of limbs or other extremities that have been amputated.

Abstract: The invention provides compositions and methods for protecting organs, such as lungs, from injury associated with transplantation. Specifically, the invention relates to secoisolaricirecinol diglucoside (SDG), including natural SDG, synthetic SDG (LGM2605), (S,S)-SDG, (R,R)-SDG and mixtures thereof, as well as related molecules, for protecting lungs from injury, such as ischemia/reperfusion injury, associated with transplantation.

Abstract: The invention provides compositions and methods for protecting organs, such as lungs, from injury associated with transplantation. Specifically, the invention relates to secoisolaricirecinol diglucoside (SDG), including natural SDG, synthetic SDG (LGM2605), (S,S)-SDG, (R,R)-SDG and mixtures thereof, as well as related molecules, for protecting lungs from injury, such as ischemia/reperfusion injury, associated with transplantation.