Patents by Inventor Edward CHOUCHANI

Edward CHOUCHANI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COVALENT INHIBITORS OF CREATINE KINASE (CK) AND USES THEREOF FOR TREATING AND PREVENTING CANCER
    Publication number: 20230399304
    Abstract: The present disclosure relates to compounds that are capable of inhibiting creatine kinase. The present disclosure also relates to methods of treating cancer, such as hematological malignancies.
    Type: Application
    Filed: October 22, 2021
    Publication date: December 14, 2023
    Inventors: Nathanael S. Gray, Edward Chouchani, Tinghu Zhang, Narek Darabedian, Wenzhi JI, Jianwei Che
  • SMALL MOLECULE COVALENT ACTIVATORS OF UCP1
    Publication number: 20230271932
    Abstract: Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) are useful for activating uncoupling protein 1 (UCP1) dependent thermogenesis. Also disclosed herein are methods of treating obesity or metabolic disorders such as diabetes using a compound of Formula (I).
    Type: Application
    Filed: June 16, 2021
    Publication date: August 31, 2023
    Inventors: Nathanael S. Gray, Mengyang Fan, Martha Ordonez, Edward Chouchani, Tinghu Zhang, Zhengnian LI, Jianwei Che
  • Succinate dehydrogenase inhibitors (SDHi's)
    Patent number: 10603298
    Abstract: The invention relates to a succinate dehydrogenase inhibitor or a prodrug and/or a pharmaceutically acceptable salt thereof for use in the treatment or prevention of reperfusion injury, such as ischemia-reperfusion injury, by inhibiting the accumulation of succinate, wherein the inhibitor or prodrug and/or pharmaceutically acceptable salt thereof is a cell-permeable reversible inhibitor of succinate dehydrogenase.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: March 31, 2020
    Inventors: Edward Chouchani, Thomas Krieg, Michael Patrick Murphy, Lorraine Work, Christian Frezza, Kourosh Saeb-Parsy
  • SUCCINATE DEHYDROGENASE INHIBITORS (SDHI's)
    Publication number: 20170135977
    Abstract: The invention relates to a succinate dehydrogenase inhibitor or a prodrug and/or a pharmaceutically acceptable salt thereof for use in the treatment or prevention of reperfusion injury, such as ischemia-reperfusion injury, by inhibiting the accumulation of succinate, wherein the inhibitor or prodrug and/or pharmaceutically acceptable salt thereof is a cell-permeable reversible inhibitor of succinate dehydrogenase.
    Type: Application
    Filed: July 3, 2015
    Publication date: May 18, 2017
    Inventors: Edward CHOUCHANI, Thomas KRIEG, Michael Patrick MURPHY, Lorraine WORK, Christian FREZZA