Abstract: Methods of producing hydrocarbon materials from a geologic formation may include accessing a consortium of microorganisms in a geologic formation that includes a carbonaceous material. The methods may include delivering an aqueous material incorporating deuterium oxide to the consortium of microorganisms. The methods may include increasing production of hydrocarbon materials by the consortium of microorganisms. The methods may include recovering a deuterium-containing hydrocarbon from the geologic formation.

Abstract: The invention relates to the field of downstream processing (DSP) of an alkaline phosphatase (AP). More specifically, it relates to a method for reducing host cell protein content in a composition comprising AP. The invention further relates to a composition comprising an AP and a reduced content of a host cell protein.

Abstract: The invention relates to the field of downstream processing (DSP) of an alkaline phosphatase (AP). More specifically, it relates to a method for reducing host cell protein content in a composition comprising AP. The invention further relates to a composition comprising an AP and a reduced content of a host cell protein.

Abstract: Methods of enhancing oil recovery may include accessing a consortium of microorganisms in a geologic formation that includes oil. The methods may include delivering an aqueous material incorporating dissolved hydrogen to the consortium of microorganisms. The methods may include increasing production of gaseous materials by the consortium of microorganisms. The methods may also include recovering oil from the reservoir.

Abstract: The present invention concerns new methods of fabricating a silicon material comprising phosphorus. The methods allow high levels of phosphorus to be combined with the silicon. In one aspect of the invention a sample of phosphorus is surrounded with a sample of silicon. At least some of the phosphorus is then vaporised and caused to interact with the silicon.

Abstract: Embodiments of the invention provide methods, apparatus, and articles of manufacture for editing network parts present a computer-aided design (CAD) model of a utility network using grips. The network parts may represent elements present in a real-world utility network. Among others, the grips may include a part size grip and a structure rotation grip. When a user selects a part size grip, a graphical user interface may display hash marks to indicate a variety of sizes of the network part provided by a network parts catalog. Dragging the resize grip may cause it to jump from one hash mark to the next, allowing the user to easily select one of the available part sizes. A structure rotation grip may be used to rotate a network part representing a utility network structure about an asymmetric axis.

Abstract: One embodiment of the invention provides a method for generating a curved pipe object in a computer-aided design drawing where the geometry of a curved pipe object is generally represented as a segment of a helix. A user selects a curved pipe creation method and a set of geometric attributes from which the helix parameters may be determined. From the helix parameters, a display representation of the curved pipe object may then be generated and displayed in the CAD drawing.

Abstract: One embodiment of the invention provides a method for modeling a variety of three-dimensional (3D) utility networks constructed from individual parts. In one embodiment, users may construct a utility network by selecting and assembling a network of inter-connected parts, where each part may be associated one or more design rules. When a part is placed within the model, the rules corresponding to the part may be applied. The network part rules may be configured to adjust the position, properties or attributes associated with a network part to comply with a rule. Alternatively, a user interface display may provide an indication of any network parts of a 3D model that violate a particular network part rule.

Abstract: Embodiments of the invention provide a method, apparatus and article of manufacture for modeling a variety of three-dimensional (3D) utility networks constructed from individual network part elements. In one embodiment, users may construct a utility network by selecting and assembling a network of inter-connected parts, where each part is selected from a pipe and structure list. Connectivity among parts is established through part placement. Structure and connected pipe properties may be managed as a single property set. As parts are placed in the utility network, auto-sizing logic resizes existing structures to connected pipes. Pipes and structures are represented by part model data that defines a set of common behavior and properties. When a user modifies part model data or property sets or moves inter-connected parts, a logic component resizes and automatically updates any associated two-dimensional and three-dimensional views of the utility network.

Abstract: The present invention provides methods for preventing, managing, treating and/or ameliorating a Respiratory Syncytial Virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), otitis media (preferably, stemming from, caused by or associated with a RSV infection, such as a RSV URI and/or LRI), and/or a symptom or respiratory condition relating thereto (e.g., asthma, wheezing, and/or reactive airway disease (RAD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity. In some embodiments, one or more antibodies comprise a modified IgG constant domain, or FcRn-binding fragment thereof resulting in longer in vivo serum half-life.

Abstract: A method, apparatus, and article of manufacture provide the ability to update a drawing surface in a CAD/GIS computer application. First, a drawing surface is displayed in a CAD/GIS application. A surface edit operation is then performed on the drawing surface. The CAD/GIS application then determines if an automatic rebuild option is active. If the rebuild option is active, the drawing surface is dynamically and automatically rebuilt to reflect the surface edit operation. Alternatively, if the automatic rebuild option is inactive (e.g., toggled off), the drawing surface is flagged as out-of-date.

Abstract: A method, apparatus, and article of manufacture provide the ability to manipulate a drawing surface in a CAD/GIS computer application. A drawing surface is displayed in a CAD/GIS application followed by the performance of a surface edit operation on the drawing surface. The surface edit operation is stored/saved as an atomic property in a list of surface edit operations. The list of surface edit operations is displayed in a graphical user interface (GUI). Each surface edit operation may be independently toggled on/off in the GUI and such toggling is reflected in the CAD/GIS application by displaying an effect of executing the surface edit operation if toggled on and displaying the drawing surface without execution of the surface edit operation if toggled off.

Abstract: Fusion polypeptides and aggregates of polypeptides comprising papillomavirus-derived antigens, and compositions thereof and their use e.g. with adjuvants for immunogenic and vaccine purposes in eliciting e.g. HPV-specific immune responses. The polypeptides can be purified to result in aggregates which when in solution or dispersion can pass through a sterilisation filter, and in amorphous aggregates. An example of such a polypeptide is a fusion protein of human papillomavirus proteins L2 and E7.

Abstract: Fusion polypeptides and aggregates of polypeptides comprising papillomavirus-derived antigens, and compositions thereof and their use e.g. with adjuvants for immunogenic and vaccine purposes in eliciting e.g. HPV-specific immune responses. The polypeptides can be purified to result in aggregates which when in solution or dispersion can pass through a sterilisation filter, and in amorphous aggregates. An example of such a polypeptide is a fusion protein of human papillomavirus proteins L2 and E7.

Abstract: A childproof cap for use with a floating chlorine feeder in a swimming pool is disclosed has a two stage process required for removal of the cap onto the feeder. The cap and the top of the feeder have cooperating circumferential series of alternating wide and narrow beads located thereon, with the cap being locked tightly on the feeder when the wide beads on the cap are aligned in a first interference fit with the wide beads on the feeder in a first childproof mechanism. After turning the cap ninety degrees, the cap may be removed by overcoming a second interference fit requiring a minimum force to pull the cap of the feeder, the second interference fit being the second childproof mechanism.