Abstract: Dynamic timers are determined using machine learning. The timers are used to control the amount of time that new data transaction requests wait before being processed by a data transaction processing system. The timers are adjusted based on changing conditions within the data transaction processing system. The dynamic timers may be determined using machine learning inference based on feature values calculated as a result of the changing conditions.

Abstract: Dynamic timers are determined using machine learning. The timers are used to control the amount of time that new data transaction requests wait before being processed by a data transaction processing system. The timers are adjusted based on changing conditions within the data transaction processing system. The dynamic timers may be determined using machine learning inference based on feature values calculated as a result of the changing conditions.

Abstract: Dynamic timers are determined using machine learning. The timers are used to control the amount of time that new data transaction requests wait before being processed by a data transaction processing system. The timers are adjusted based on changing conditions within the data transaction processing system. The dynamic timers may be determined using machine learning inference based on feature values calculated as a result of the changing conditions.

Abstract: Dynamic timers are determined using machine learning. The timers are used to control the amount of time that new data transaction requests wait before being processed by a data transaction processing system. The timers are adjusted based on changing conditions within the data transaction processing system. The dynamic timers may be determined using machine learning inference based on feature values calculated as a result of the changing conditions.

Abstract: A composition includes a blend of (a) a multi-block copolymer including at least one block of an elastomeric polymer and at least one block of a first polymer including a chiral polymer having a stereo isomeric configuration; and (b) a second polymer including an anti-chiral polymer corresponding to the chiral polymer in (a), wherein the second polymer includes an opposite handed stereo isomeric configuration to the chiral polymer in (a); wherein the blend of the chiral polymer and the anti-chiral polymer form stereo complex sites. A flexible tubing material further includes the blend. In an embodiment, a method of making the blend material is also provided.

Abstract: The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.

Abstract: A system and method of guiding knowledge management including a knowledge artifact guiding system server including an ontological lexicon, a game rule base and interest group management. The system further include a knowledge artifact guiding system client including a guided context processor subsystem with a contextual processor and a post contextual processor, and a human computer interface with a natural language handler, a game display algorithm engine and a game position move adapter. The ontological lexicon is configured to provide lexicon updates to the knowledge artifact guiding system server and the interest group management is configured to provide position data to the knowledge artifact guiding system server. The guided contextual processor subsystem and the knowledge artifact guiding system server share knowledge artifact classification contexts and suggested knowledge artifacts.

Abstract: The invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing methods for simplifying NMR spectra using labeled proteins prepared from specifically isotopically labeled amino acids having at least two isotopes of 13C, 15N and 2H in the backbone, and methods for making these labeled proteins, e.g., by cultivation of a microbial culture containing said labeled amino acids.

Abstract: This invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing methods for simplifying NMR spectra using labeled proteins prepared from specifically isotopically labeled amino acids having at least two isotopes of 13C, 15N and 2H in the backbone, and methods for making these labeled proteins, e.g., by cultivation of a microbial culture containing said labeled amino acids.

Abstract: This invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing methods for simplifying NMR spectra using labeled proteins prepared from specifically isotopically labeled amino acids having at least two isotopes of 13C, 15N and 2H in the backbone, and methods for making these labeled proteins, e.g., by cultivation of a microbial culture containing said labeled amino acids.

Abstract: Peptidic molecules suitable for three dimensional NMR structure determination are provided which have been substituted with .sup.13 C and/or .sup.15 N in the backbone and/or at the .alpha.-carbon with .sup.2 H but not otherwise in the sidechains of the amino acid residues. One or more amino acids, amino acid species or substantially all of the amino acid residues of the molecule may be so substituted. A method of making the substituted peptidic molecules substituted in this manner is provided.

Abstract: This metal heating method includes burning an air-gas fuel mixture as it flows into a furnace, flowing hot exhaust gases out of the furnace to an exhaust stack after it has impinged on or been brought into association with the metal in the furnace for heating the same, and thereafter measuring the temperature of gases in the stack. This gas temperature is used for controlling the pressure of the air and also of the gas fuel supplied to the furnace for combustion and with the pressure supplied being reduced when temperatures excessive to predetermined temperatures exist in the stack, but at the same time, a desired high fuel-to-air ratio is maintained to provide a reducing atmosphere in the furnace.