Patents by Inventor EDWARD D'ANTONIO

EDWARD D'ANTONIO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • One-step synthesis of phosphate-based inhibitors and applications thereof
    Patent number: 11555047
    Abstract: One-step methods for forming phosphate-based enzyme inhibitors are disclosed. Methods include reacting o-phosphorylethanolamine with an acyl chloride at acidic conditions. Acyl chlorides can be derivatized. The phosphate-based enzyme inhibitors can inhibit enzymes of the pentose phosphate pathway including D-ribose-5-phosphate aldose-ketose isomerase enzymes such as T. cruzi ribose 5-phosphate isomerase type B and D-ribulose-5-phosphate 3-epimerase enzymes. Methods can be used in forming pharmaceutical compositions for use in treatment of disease caused by kinetoplastid parasites including T. cruzi, T. brucei, and Leishmania spp.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: January 17, 2023
    Assignees: University of South Carolina, North Carolina State University
    Inventors: Edward D'Antonio, Joshua Pierce
  • Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
    Patent number: 11059842
    Abstract: Inhibitor compounds with biological activity against kinetoplastid parasites, along with methods of use of the compounds, are provided. The compounds can be used to strongly inhibit key drug targets found in protozoan parasites, e.g., the target Trypanosoma cruzi glucokinase. Compounds include derivatives of 3-nitro-2-phenyl-2H-chromene, and monosaccharide amines including D-glucosamine, D-mannosamine, D-galactosamine, and D-fructosamine.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: July 13, 2021
    Assignee: University of South Carolina
    Inventor: Edward D'Antonio
  • One-Step Synthesis of Phosphate-Based Inhibitors and Applications Thereof
    Publication number: 20210130381
    Abstract: One-step methods for forming phosphate-based enzyme inhibitors are disclosed. Methods include reacting o-phosphorylethanolamine with an acyl chloride at acidic conditions. Acyl chlorides can be derivatized. The phosphate-based enzyme inhibitors can inhibit enzymes of the pentose phosphate pathway including D-ribose-5-phosphate aldose-ketose isomerase enzymes such as T. cruzi ribose 5-phosphate isomerase type B and D-ribulose-5-phosphate 3-epimerase enzymes. Methods can be used in forming pharmaceutical compositions for use in treatment of disease caused by kinetoplastid parasites including T. cruzi, T. brucei, and Leishmania spp.
    Type: Application
    Filed: August 28, 2020
    Publication date: May 6, 2021
    Inventors: EDWARD D'ANTONIO, JOSHUA PIERCE
  • Monosaccharide Amine and 3-Nitro-2-Phenyl-2H-Chromene Based Inhibitors of Glucose Kinases
    Publication number: 20200339619
    Abstract: Inhibitor compounds with biological activity against kinetoplastid parasites, along with methods of use of the compounds, are provided. The compounds can be used to strongly inhibit key drug targets found in protozoan parasites, e.g., the target Trypanosoma cruzi glucokinase. Compounds include derivatives of 3-nitro-2-phenyl-2H-chromene, and monosaccharide amines including D-glucosamine, D-mannosamine, D-galactosamine, and D-fructosamine.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 29, 2020
    Inventor: EDWARD D'ANTONIO