Abstract: Embodiments of the present disclosure are directed processes to produce a low-color esterified oil soluble polyalkylene glycol, the process comprising forming a reaction mixture including a low viscosity oil soluble polyalkylene glycol and an excess amount of valeric acid, where the reaction mixture is formed in the presence of a catalytic amount of ortho-phosphoric acid catalyst to yield an organic phase including the low-color esterified oil soluble polyalkylene glycol.

Abstract: The invention relates to an improved process for the preparation of an advanced synthetic intermediate of ACE inhibitors. In one aspect, the present invention is based on a novel process for the preparation of an aldehyde of formula (I), wherein (N)PrG is a protected amino group, R is an alkyl or aralkyl group and X1-4 are each independently H or a non-reacting substituent, which comprises hydroformylation of an ?-olefin of formula (II), by reaction with syngas (CO/H2) in the presence of, as catalyst, a group VIII transition metal complex of a phosphorus-containing ligand. Aldehyde (I), the product of linear hydroformylation, is formed in preference to aldehyde (III). In another aspect of the invention, ?-olefin (II) is a novel composition. The process to convert (II) to (I) enables an efficient manufacturing route to MDL 28,726 and analogues.

Abstract: A substituted polyethylene glycol compound and process for making. The compound has the formula RO(C2H4O)nH wherein R represents a C1-7 hydrocarbon group and n represents the average number of moles of C2H4O groups, ranging from 500 to 2000. The compound has a ratio of weight average molecular weight to a number average molecular weight in the range of from 1 to 1.1. The compound contains less than ten weight percent polyethylene glycol. The gist of the process is the use of an aprotic polar solvent. When the aprotic polar solvent is a polyether solvent, then the n value of the compound ranges from 100 to 2000.

Abstract: The present invention provides a method for producing an enantiomerically enriched ?-(phenoxy)phenylactic acid compound of the formula: from its enantiomeric mixture, where R1 is alkyl or haloalkyl and X is halide.

Abstract: A process for making an amino acid by the steps of: (a) contacting a compound of formula I with a hydroformylation catalyst and synthesis gas to produce a mixture of aldehyde compounds comprising the formulas IIa, IIb and IIc; (b) reacting the mixture of aldehyde compounds from step (a) to produce a mixture of derivative compounds; (c) contacting the mixture of derivative compounds from step (b) with an enantioselective hydrolase enzyme in the presence of water to produce an L-amino acid having the formula IV; (d) isolating the amino acid having the formula IV in substantially pure form, wherein in formulas I, IIa, IIb, IIc, IIIa, IIIb, IIIc and IV, R is H, alkyl or aryl and R1 and R2 are the same or different alkyl groups and wherein R1 and R2 may be fused

Abstract: A substituted polyethylene glycol compound and process for making. The compound has the formula RO(C2H4O)nH wherein R represents a C1-7 hydrocarbon group and n represents the average number of moles of C2H4O groups, ranging from 500 to 2000. The compound has a ratio of weight average molecular weight to a number average molecular weight in the range of from 1 to 1.1. The compound contains less than ten weight percent polyethylene glycol. The gist of the process is the use of an aprotic polar solvent. When the aprotic polar solvent is a polyether solvent, then the n value of the compound ranges from 100 to 2000.

Abstract: The invention is directed toward novel high molecular weight and high purity mPEG alcohol compositions as well as a process for obtaining said compositions by removing PEG diols from the mPEG alcohol after polymerization is complete.

Abstract: The present invention provides a method for producing an enantiomerically enriched ?-(phenoxy)phenylacetic acid compound of the formula: from its enantiomeric mixture, where R1 is alkyl or haloalkyl and X is halide.