Patents by Inventor Edward Dennis LaChapelle

Edward Dennis LaChapelle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multiparticulates of spray-coated drug and polymer on a meltable core
    Patent number: 11116728
    Abstract: A pharmaceutical composition comprises multiparticulates comprising a melt-congeal core and a solid amorphous dispersion layer of a poorly water soluble drug and polymer. The multiparticulates are suitable for improving bioavailability of poorly water soluble drugs. The melt-congeal cores facilitate application of the solid amorphous dispersion layer, and allow incorporation of additional optional components to the core so as to adjust the release of drug from the multiparticulate.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: September 14, 2021
    Assignee: Bend Research, Inc.
    Inventors: Dwayne Thomas Friesen, Leah E. Appel, Joshua Richard Shockey, Sanjay Konagurthu, Edward Dennis LaChapelle
  • Pharmaceutical compositions and dosage forms
    Patent number: 11007191
    Abstract: The present disclosure relates to pharmaceutical compositions comprising N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)-benzamide and a polymer, dosage forms comprising the formulation and methods of treating subjects having cancer.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: May 18, 2021
    Assignee: IGNYTA, INC.
    Inventors: Robert Orr, Kathryn Emily Colombo Pugh, Matthew Jarud Shaffer, Brent Antone Uhrig, Edward Dennis Lachapelle, Charlie Michael McLaughlin
  • PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS
    Publication number: 20200237756
    Abstract: The present disclosure relates to pharmaceutical compositions comprising N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)-benzamide and a polymer, dosage forms comprising the formulation and methods of treating subjects having cancer.
    Type: Application
    Filed: April 14, 2020
    Publication date: July 30, 2020
    Inventors: Robert ORR, Kathryn Emily Colombo PUGH, Matthew Jarud SHAFFER, Brent Antone UHRIG, Edward Dennis LACHAPELLE, Charlie Michael MCLAUGHLIN
  • MULTIPARTICULATES OF SPRAY-COATED DRUG AND POLYMER ON A MELTABLE CORE
    Publication number: 20190307702
    Abstract: A pharmaceutical composition comprises multiparticulates comprising a melt-congeal core and a solid amorphous dispersion layer of a poorly water soluble drug and polymer. The multiparticulates are suitable for improving bioavailability of poorly water soluble drugs. The melt-congeal cores facilitate application of the solid amorphous dispersion layer, and allow incorporation of additional optional components to the core so as to adjust the release of drug from the multiparticulate.
    Type: Application
    Filed: June 13, 2019
    Publication date: October 10, 2019
    Applicant: Bend Research, Inc.
    Inventors: Dwayne Thomas Friesen, Leah E. Appel, Joshua Richard Shockey, Sanjay Konagurthu, Edward Dennis LaChapelle
  • Multiparticulates of spray-coated drug and polymer on a meltable core
    Patent number: 10357462
    Abstract: A pharmaceutical composition comprises multiparticulates comprising a melt-congeal core and a solid amorphous dispersion layer of a poorly water soluble drug and polymer. The multiparticulates are suitable for improving bioavailability of poorly water soluble drugs. The melt-congeal cores facilitate application of the solid amorphous dispersion layer, and allow incorporation of additional optional components to the core so as to adjust the release of drug from the multiparticulate.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: July 23, 2019
    Assignee: Ben Research, Inc.
    Inventors: Dwayne Thomas Friesen, Leah E. Appel, Joshua Richard Shockey, Sanjay Konagurthu, Edward Dennis LaChapelle
  • Taste-masked drugs in rupturing multiparticulates
    Patent number: 8236349
    Abstract: A pharmaceutical composition comprises multiparticulates comprising a drug, a matrix material, and swelling agent. In one aspect, the multiparticulates comprise a core comprising a drug, and a coating surrounding the core. The coating is selected from the group consisting of (i) a water-permeable, substantially drug-impermeable coating, and (ii) an anti-enteric coating.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: August 7, 2012
    Assignee: Bend Research Inc.
    Inventors: Leah Elizabeth Appel, Dwayne Thomas Friesen, Edward Dennis LaChapelle, Sanjay Konagurthu, Richard Frank Falk, Joseph P. Reo
  • MULTIPARTICULATES OF SPRAY-COATED DRUG AND POLYMER ON A MELTABLE CORE
    Publication number: 20100068276
    Abstract: A pharmaceutical composition comprises multiparticulates comprising a melt-congeal core and a solid amorphous dispersion layer of a poorly water soluble drug and polymer. The multiparticulates are suitable for improving bioavailability of poorly water soluble drugs. The melt-congeal cores facilitate application of the solid amorphous dispersion layer, and allow incorporation of additional optional components to the core so as to adjust the release of drug from the multiparticulate.
    Type: Application
    Filed: November 19, 2007
    Publication date: March 18, 2010
    Inventors: Dwayne Thomas Friesen, Leah E. Appel, Joshua Richard Shockey, Sanjay Konagurhu, Edward Dennis LaChapelle