Patents by Inventor Edward E. Durrant
Edward E. Durrant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11940358Abstract: Presented herein are methods of improving the consistency of staining with a counterstain. In some embodiments, the method makes use of an automated specimen processing apparatus or other staining device. In some embodiments, the staining methods are applied manually. In some embodiments, the counterstain includes eosin.Type: GrantFiled: June 3, 2020Date of Patent: March 26, 2024Assignee: Ventana Medical Systems, Inc.Inventors: Benjamin H. Blehm, Evan T. Graves, Edward E. Durrant
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Publication number: 20230097824Abstract: A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.Type: ApplicationFiled: November 4, 2022Publication date: March 30, 2023Inventors: Edward E. Durrant, Dieter Heindl, Florian Mauritius Erasumu Huber, Eric Klein, Jerome W. Kosmeder, II, Edgar Voss
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Publication number: 20220090993Abstract: The present disclosure provides stabilized hematoxylin formulations having a pH of less than 2.4. The present disclosure also provides methods of using such stabilized hematoxylin formulations to stain biological samples.Type: ApplicationFiled: December 2, 2021Publication date: March 24, 2022Inventors: Edward E. Durrant, Christopher A. Koerber
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Publication number: 20210223146Abstract: Methods and compositions for removing precipitates or reducing the formation of precipitates generated in hematoxylin solutions. The methods and compositions feature cleaning solutions that feature chemical compounds that initiate processes including but not limited to acidification of the waste solution, chelation of metal ions in the waste solution, reduction reactions, oxidation reactions, and metal salt addition reactions.Type: ApplicationFiled: April 5, 2021Publication date: July 22, 2021Inventors: Edward E. Durrant, Henning Groll, Casey A. Kernag, Charles H. Weidner, Kenneth S. Weir
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Patent number: 10976223Abstract: Methods and compositions for removing precipitates or reducing the formation of precipitates generated in hematoxylin solutions. The methods and compositions feature cleaning solutions that feature chemical compounds that initiate processes including but not limited to acidification of the waste solution, chelation of metal ions in the waste solution, reduction reactions, oxidation reactions, and metal salt addition reactions.Type: GrantFiled: November 17, 2017Date of Patent: April 13, 2021Assignee: Ventana Medical Systems, Inc.Inventors: Edward E. Durrant, Henning Groll, Casey A. Kernag, Charles H. Weidner, Kenneth S. Weir
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Patent number: 10888209Abstract: A cleaning apparatus is disclosed for extracting a liquid from a surface. The apparatus includes at least one extraction head that has at least one aperture that is facing the surface to be cleaned. The vacuum cleaner includes a vacuum pathway situated between the at least one extraction head and a riser that is connected to a vacuum motor. The internal surfaces of the vacuum pathway are smooth and the vacuum pathway has certain dimensions and orientations that optimize the extraction of a liquid from a surface.Type: GrantFiled: September 17, 2012Date of Patent: January 12, 2021Assignee: Harris Research, Inc.Inventors: Edward E. Durrant, Dale S. Jensen, Craig L. Donaldson, Roger C. Andersen, Monte G. Taylor
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Patent number: 10830675Abstract: This disclosure relates to hematoxylin staining formulations and particularly to formulations for use in autostainers. The disclosed compositions were discovered to possess atypical stability under storage while having high stain quality and sufficiently fast staining performance. The disclosed hematoxylin staining compositions include a solvent system, hematoxylin, a chemical oxidant, and a mordant. Illustrative embodiments also have a Cl?/SO4? molar ratio of between about 2.5/1 and about 1/4.Type: GrantFiled: June 19, 2017Date of Patent: November 10, 2020Assignee: Ventana Medical Systems, Inc.Inventors: Heidi Barnett, Edward E. Durrant, Eric L. Klein, Michael Lynch, Kevin H. Pritchard
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Publication number: 20200340892Abstract: Presented herein are methods of improving the consistency of staining with a counterstain. In some embodiments, the method makes use of an automated specimen processing apparatus or other staining device. In some embodiments, the staining methods are applied manually. In some embodiments, the counterstain includes eosin.Type: ApplicationFiled: June 3, 2020Publication date: October 29, 2020Inventors: Benjamin H. Blehm, Evan T. Graves, Edward E. Durrant
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Patent number: 10646088Abstract: A cleaning system is disclosed that includes a vehicle that has a cooling system for circulating a coolant, a diverter coupled with the cooling system that is configured to divert the coolant through a heat exchanger, a pump configured to pump a cleaning solution through the heat exchanger so that the heat exchanger heats the cleaning solution without mixing the coolant and the cleaning solution, and a rotary head cleaner in fluid communication with the heat exchanger for receiving the cleaning solution and applying the cleaning solution to a floor.Type: GrantFiled: September 17, 2012Date of Patent: May 12, 2020Assignee: Harris Research, Inc.Inventors: Edward E. Durrant, Monte G. Taylor
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Publication number: 20200041390Abstract: The present disclosure provides stabilized hematoxylin formulations having a pH of less than 2.4. The present disclosure also provides methods of using such stabilized hematoxylin formulations to stain biological samples.Type: ApplicationFiled: October 15, 2019Publication date: February 6, 2020Inventors: Edward E. Durrant, Christopher A. Koerber
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Patent number: 10295443Abstract: A process for removing hematoxylin precipitate from a surface of an automated hematoxylin stainer, systems adapted for performing such processes. The process and systems use a hematein precipitate removal solution having a pH in the range of between about 8.9 and 10.5 and including a liquid oxidizing component and alkaline component. The hematein precipitate removal solution is placed in contact with a surface of the automated hematoxylin stainer, thereby dissolving any hematein precipitate deposited thereon.Type: GrantFiled: October 28, 2016Date of Patent: May 21, 2019Assignee: Ventana Medical Systems, Inc.Inventor: Edward E. Durrant
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Publication number: 20180172563Abstract: Methods and compositions for removing precipitates or reducing the formation of precipitates generated in hematoxylin solutions. The methods and compositions feature cleaning solutions that feature chemical compounds that initiate processes including but not limited to acidification of the waste solution, chelation of metal ions in the waste solution, reduction reactions, oxidation reactions, and metal salt addition reactions.Type: ApplicationFiled: November 17, 2017Publication date: June 21, 2018Inventors: Edward E. Durrant, Henning Groll, Casey A. Kernag, Charles H. Weidner, Kenneth S. Weir
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Publication number: 20170284908Abstract: This disclosure relates to hematoxylin staining formulations and particularly to formulations for use in autostainers. The disclosed compositions were discovered to possess atypical stability under storage while having high stain quality and sufficiently fast staining performance. The disclosed hematoxylin staining compositions include a solvent system, hematoxylin, a chemical oxidant, and a mordant. Illustrative embodiments also have a Cl?/SO4? molar ratio of between about 2.5/1 and about 1/4.Type: ApplicationFiled: June 19, 2017Publication date: October 5, 2017Inventors: Heidi Barnett, Edward E. Durrant, Eric L. Klein, Michael Lynch, Kevin H. Pritchard
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Publication number: 20170045429Abstract: A process for removing hematoxylin precipitate from a surface of an automated hematoxylin stainer, systems adapted for performing such processes. The process and systems use a hematein precipitate removal solution having a pH in the range of between about 8.9 and 10.5 and including a liquid oxidizing component and alkaline component. The hematein precipitate removal solution is placed in contact with a surface of the automated hematoxylin stainer, thereby dissolving any hematein precipitate deposited thereon.Type: ApplicationFiled: October 28, 2016Publication date: February 16, 2017Inventor: Edward E. Durrant
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Patent number: 9267227Abstract: A system and method are disclosed for an odor removal treatment system that includes a liquid oxidizing agent that includes a peroxide and water, a liquid buffering agent that includes a carbonate salt and water, and a cleaning device, wherein the liquid oxidizing agent is stored separately from the liquid buffering agent in a pre-application mode, and combinable with the liquid buffering agent to form a solution in an application mode just prior to applying the solution to a textile. The cleaning device may be a portable vacuum cleaning mechanism onboard a vehicle. The peroxide may be hydrogen peroxide and the solution may have a hydrogen peroxide weight percent of about 1.5%.Type: GrantFiled: October 25, 2012Date of Patent: February 23, 2016Assignee: Harris Research, Inc.Inventor: Edward E. Durrant
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Patent number: 9259671Abstract: The present disclosure relates to a defoaming substance for defoaming an aqueous solution. The defoaming substance includes a defoaming agent and a carrier material intermixed with the defoaming agent to form a solid mass, the carrier material being at least minimally soluble in the aqueous solution. In one embodiment, the carrier material includes at least one type of organic acid. The defoaming agent may include at least one type of silicon-based defoamer. The present disclosure also relates to a method for making a defoaming substance. The method may include selecting a defoaming agent capable of hindering foam formation and reducing foam build-up in an aqueous solution, selecting a carrier material that is at least minimally soluble in the aqueous solution, combining the defoaming agent with the carrier material, and forming the combined defoaming agent and carrier material into a solid defoaming substance.Type: GrantFiled: December 20, 2012Date of Patent: February 16, 2016Assignee: Harris Research, Inc.Inventors: Edward E. Durrant, Dale S. Jensen, Roger C. Andersen
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Publication number: 20130327991Abstract: The present disclosure relates to an anti-corrosion substance that includes an anti-corrosion agent and a carrier material. The carrier material is at least minimally soluble in aqueous solutions. An anti-corrosion apparatus is also disclosed, the apparatus including an anti-corrosion agent and a carrier configured to controllably exude the contained anti-corrosion agent. Also disclosed is a method for producing a block of anti-corrosion substance, which includes selecting an anti-corrosion agent, selecting a carrier material, combining the anti-corrosion agent with the carrier material, and forming the anti-corrosion substance from the combination of the anti-corrosion agent and the carrier material.Type: ApplicationFiled: March 22, 2013Publication date: December 12, 2013Inventors: Edward E. Durrant, Dale S. Jensen, Roger C. Andersen
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Publication number: 20130067683Abstract: A cleaning apparatus is disclosed for extracting a liquid from a surface. The apparatus includes at least one extraction head that has at least one aperture that is facing the surface to be cleaned. The vacuum cleaner includes a vacuum pathway situated between the at least one extraction head and a riser that is connected to a vacuum motor. The internal surfaces of the vacuum pathway are smooth and the vacuum pathway has certain dimensions and orientations that optimize the extraction of a liquid from a surface.Type: ApplicationFiled: September 17, 2012Publication date: March 21, 2013Applicant: HARRIS RESEARCH, INC.Inventors: Edward E. Durrant, Dale S. Jensen, Craig L. Donaldson, Roger C. Andersen, Monte G. Taylor
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Publication number: 20120023698Abstract: An apparatus is disclosed for a rotary head cleaner. The apparatus includes a plurality of liquid extraction devices positioned radially on a floor-facing surface of a rotary head, a driveshaft disposed between a rotary motor configured to rotate the rotary head, and a housing disposed between the rotary motor and the rotary head for supporting a wheel, and a handle. The apparatus also includes an evacuation tank having a capacity sensor in communication with an evacuation pump, the capacity sensor configured to detect when a maximum desired capacity of evacuated liquids is reached, a vacuum motor connected with the housing and configured to provide a suction force to the liquid extraction devices to extract liquid from a floor to the evacuation tank, and wherein a weight of the rotary motor, housing, handle, retractable wheel, and vacuum motor is supported by the liquid extraction devices.Type: ApplicationFiled: July 28, 2011Publication date: February 2, 2012Applicant: HARRIS RESEARCH, INC.Inventors: Edward E. Durrant, Dale S. Jensen, Craig L. Donaldson, Monte G. Taylor
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Patent number: 8097575Abstract: A method and new use of an aqueous composition including a surfactant and a buffering agent, wherein the new use and method include the steps of applying the composition to a surface with an acidic finish, etching the surface, and removing the aqueous composition. The removal may be by evaporation. A new finish may be applied to the surface. Methods are disclosed for the cleaning and neutralizing of an existing finish to allow for the application of a new finish. Also disclosed are compositions for the cleaning and neutralizing of an existing finish without complete removal of the existing finish. The compositions include a buffering agent configured to neutralize the existing finish, and a surfactant.Type: GrantFiled: July 22, 2005Date of Patent: January 17, 2012Assignee: Harris Research, Inc.Inventor: Edward E. Durrant