Patents by Inventor Edward E. Mitre

Edward E. Mitre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogenic compositions and vaccines for preventing or treating filarial disease
    Patent number: 10441642
    Abstract: The present disclosure is directed to an immunogenic composition including: at least one or at least two isolated polypeptides or immunogenic fragments thereof, and optionally a pharmaceutically acceptable carrier, wherein each polypeptide is expressed on a luminal surface of an intestine of a filarial worm, wherein each polypeptide is expressed at a level at least two-fold higher in the intestine in comparison to the level of expression of each polypeptide in a reproductive tract or a body wall of the filarial worm, wherein each isolated polypeptide has at least one transmembrane domain, and wherein each polypeptide is a non-mitochondrial polypeptide. Also provided herein is a method for preventing or treating a filarial disease.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: October 15, 2019
    Assignees: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The United States Government, as Represented by the Secretary of the Department of Health and Human Services
    Inventors: Edward E. Mitre, Christopher Morris, Sasisekhar Bennuru, Thomas Nutman
  • METHODS OF TREATING ALLERGIES AND AUTOIMMUNE DISEASES WITH HOMOGENATE OF AXENIC C. ELEGANS
    Publication number: 20190117747
    Abstract: Methods of using axenic C. elegans homogenate for treating allergies or an autoimmune disease are disclosed. Also disclosed is a composition comprising a homogenate of C. elegans, wherein the homogenate is obtained from C. elegans cultured in axenic media, for use in treating an allergy or autoimmune disease.
    Type: Application
    Filed: December 14, 2018
    Publication date: April 25, 2019
    Applicant: The Henry M. Jackson Foundation for the Advcement of Military Medicine, Inc.
    Inventors: Edward E. Mitre, Marina Torrero, Belinda Jackson
  • Methods of treating allergies and autoimmune diseases with homogenate of axenic
    Patent number: 10213495
    Abstract: Methods of using axenic C. elegans homogenate for treating allergies or an autoimmune disease are disclosed. Also disclosed is a composition comprising a homogenate of C. elegans, wherein the homogenate is obtained from C. elegans cultured in axenic media, for use in treating an allergy or autoimmune disease.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: February 26, 2019
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Edward E. Mitre, Marina Torrero, Belinda Jackson
  • IMMUNOGENIC COMPOSITIONS AND VACCINES FOR PREVENTING OR TREATING FILARIAL DISEASE
    Publication number: 20180064791
    Abstract: The present disclosure is directed to an immunogenic composition including: at least one or at least two isolated polypeptides or immunogenic fragments thereof, and optionally a pharmaceutically acceptable carrier, wherein each polypeptide is expressed on a luminal surface of an intestine of a filarial worm, wherein each polypeptide is expressed at a level at least two-fold higher in the intestine in comparison to the level of expression of each polypeptide in a reproductive tract or a body wall of the filarial worm, wherein each isolated polypeptide has at least one transmembrane domain, and wherein each polypeptide is a non-mitochondrial polypeptide. Also provided herein is a method for preventing or treating a filarial disease.
    Type: Application
    Filed: March 17, 2016
    Publication date: March 8, 2018
    Inventors: Edward E. MITRE, Christopher MORRIS, Sasisekhar BENNURU, Thomas NUTMAN
  • METHODS OF TREATING ALLERGIES AND AUTOIMMUNE DISEASES WITH HOMOGENATE OF AXENIC C. ELEGANS
    Publication number: 20160271235
    Abstract: Methods of using axenic C. elegans homogenate for treating allergies or an autoimmune disease are disclosed. Also disclosed is a composition comprising a homogenate of C. elegans wherein the homogenate is obtained from C. elegans cultured in axenic media, for use in treating an allergy or autoimmune disease.
    Type: Application
    Filed: November 19, 2014
    Publication date: September 22, 2016
    Inventors: Edward E. Mitre, Marina Torrero, Belinda Jackson
  • Methods of treating autoimmune diseases with anti-Fc?RI antibodies
    Patent number: 8968738
    Abstract: Methods of using anti-FceRI or anti-IgE antibodies for treating an autoimmune disease are disclosed. Also disclosed is a composition comprising an anti-FceRI antibody or anti-IgE antibody for use in treating an autoimmune disease. Also disclosed are non-antibody compounds that specifically activate basophils and/or mast cells, either by cross-linking IgE or FceRI, or by activating the cells through an FceRI-independent pathway and methods of using the same to treat autoimmune diseases.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: March 3, 2015
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Edward E. Mitre, Marc P. Hübner
  • METHODS OF TREATING AUTOIMMUNE DISEASES WITH ANTI-FCERI ANTIBODIES
    Publication number: 20130171137
    Abstract: Methods of using anti-FceRI or anti-IgE antibodies for treating an autoimmune disease are disclosed. Also disclosed is a composition comprising an anti-FceRI antibody or anti-IgE antibody for use in treating an autoimmune disease. Also disclosed are non-antibody compounds that specifically activate basophils and/or mast cells, either by cross-linking IgE or FceRI, or by activating the cells through an FceRI-independent pathway and methods of using the same to treat autoimmune diseases.
    Type: Application
    Filed: September 14, 2011
    Publication date: July 4, 2013
    Applicant: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC
    Inventors: Edward E. Mitre, Marc P. Hübner