Patents by Inventor Edward E. Morrisey

Edward E. Morrisey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR IN UTERO GENE EDITING FOR MONOGENIC LUNG DISEASE
    Publication number: 20220275402
    Abstract: Compositions and methods for in utero gene editing in mammalian lung cells are disclosed.
    Type: Application
    Filed: April 6, 2020
    Publication date: September 1, 2022
    Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: William H. Peranteau, Edward E. Morrisey, Michael F. Beers, Kiran Musunuru
  • COMPOSITIONS AND METHODS FOR CARDIAC REGENERATION
    Publication number: 20200108013
    Abstract: The present disclosure provides microRNA-based therapies using a hydrogel delivery system that provides regenerative approach to myocardial infarction by targeting cardiomyocytes. The hydrogel provides for local and sustained cardiac delivery of microRNAs, such miR-302 mimics that can be used to promote cardiomyocyte proliferation. Also provided are compositions suitable for local and sustained release and methods for intramyocardial gel delivery of a miRNA oligonucleotide.
    Type: Application
    Filed: April 2, 2018
    Publication date: April 9, 2020
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Edward E. MORRISEY, Jason A. Burdick, Leo Wang
  • MicroRNA induction of cardiac regeneration
    Patent number: 10590419
    Abstract: The invention relates to compostions and methods for promoting cellular proliferation and de-differentiation of cells into stem cells to foster tissue regeneration. Specifically, the invention relates to transiently administering a microRNA (miR) or its mimic for promoting cardiomyocyte proliferation and cardiac regeneration.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: March 17, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Edward E. Morrisey
  • MICRORNA INDUCTION OF CARDIAC REGENERATION
    Publication number: 20170096671
    Abstract: The invention relates to compostions and methods for promoting cellular proliferation and de-differentiation of cells into stem cells to foster tissue regeneration. Specifically, the invention relates to transiently administering a microRNA (miR) or its mimic for promoting cardiomyocyte proliferation and cardiac regeneration.
    Type: Application
    Filed: May 15, 2015
    Publication date: April 6, 2017
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Edward E. MORRISEY
  • MicroRNA induction of pluripotential stem cells and uses thereof
    Patent number: 9115345
    Abstract: Compositions and methods for inducing the formation of an induced pluripotential stem (iPS) cell from a somatic cell are disclosed. The compositions comprise miR 302-367 cluster and valproic acid. Further disclosed are methods for treatment of a disease or condition in a subject through the use of the compositions.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: August 25, 2015
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventor: Edward E. Morrisey
  • MicroRNA induction of pluripotential stem cells and uses thereof
    Publication number: 20130035374
    Abstract: Compositions and methods for inducing the formation of an induced pluripotential stem (iPS) cell from a somatic cell are disclosed. The compositions comprise miR 302-367 cluster and valproic acid. Further disclosed are methods for treatment of a disease or condition in a subject through the use of the compositions.
    Type: Application
    Filed: March 25, 2011
    Publication date: February 7, 2013
    Inventor: Edward E. Morrisey