Abstract: The present disclosure provides a method and system for treating affective disorders such as depression and/or anxiety and/or related disorders through neuromodulatory intervention that includes brain targets within the orbitofrontal cortex (OFC). This method includes the application of electrical stimulation through an electrical signal generator device where the distal end of the device comprises at least one stimulating electrode in contact with the OFC. The treatment system includes patient selection, implantation of at least one stimulating electrode in contact with the OFC, acute or chronic electrical stimulation of the OFC, and evaluation of the effects of stimulation on clinical symptoms and status.

Abstract: Provided are methods of contextual decoding and/or speech decoding from the brain of a subject. The methods include decoding neural or optical signals from the cortical region of an individual, extracting context-related features and/or speech-related features from the neural or optical signals, and decoding the context-related features and/or speech-related features from the neural or optical signals. Contextual decoding and speech decoding systems and devices for practicing the subject methods are also provided.

Abstract: Provided are methods and systems of encoding and decoding speech from a subject using articulatory physiology. Methods of the present disclosure include receiving a physiological feature signal associated with a spatiotemporal movement of a vocal tract articulator, generating a speech pattern signal in response to the physiological feature signal, and outputting speech that is based on the speech pattern signal. Methods of the present disclosure further include acquiring one or more of a linguistic signal and an acoustic signal; associating a physiological feature with the linguistic or acoustic signal; generating a speech pattern signal in response to the physiological feature; and outputting speech that is based on the speech pattern signal. Speech decoding systems and devices using articulatory physiology for practicing the subject methods are also provided. Various steps and aspects of the methods will now be described in greater detail below.

Abstract: The present disclosure provides a method and system for treating affective disorders such as depression and/or anxiety and/or related disorders through neuromodulatory intervention that includes brain targets within the orbitofrontal cortex (OFC). This method includes the application of electrical stimulation through an electrical signal generator device where the distal end of the device comprises at least one stimulating electrode in contact with the OFC. The treatment system includes patient selection, implantation of at least one stimulating electrode in contact with the OFC, acute or chronic electrical stimulation of the OFC, and evaluation of the effects of stimulation on clinical symptoms and status.

Abstract: Provided are methods of decoding speech from the brain of a subject. The methods include detecting speech production signals from electrodes operably coupled to the speech motor cortex of a subject while the subject produces or imagines producing a speech sound. The methods further include deriving a speech production signal pattern from the detected speech production signals, and correlating the speech production signal pattern with a reference speech production signal pattern to decode speech from the brain of the subject. Speech communication systems and devices for practicing the subject methods are also provided.

Abstract: Provided are methods of decoding speech from the brain of a subject. The methods include detecting speech production signals from electrodes operably coupled to the speech motor cortex of a subject while the subject produces or imagines producing a speech sound. The methods further include deriving a speech production signal pattern from the detected speech production signals, and correlating the speech production signal pattern with a reference speech production signal pattern to decode speech from the brain of the subject. Speech communication systems and devices for practicing the subject methods are also provided.

Abstract: Provided are methods of decoding speech from the brain of a subject. The methods include detecting speech production signals from electrodes operably coupled to the speech motor cortex of a subject while the subject produces or imagines producing a speech sound. The methods further include deriving a speech production signal pattern from the detected speech production signals, and correlating the speech production signal pattern with a reference speech production signal pattern to decode speech from the brain of the subject. Speech communication systems and devices for practicing the subject methods are also provided.

Abstract: Provided are methods of decoding speech from the brain of a subject. The methods include detecting speech production signals from electrodes operably coupled to the speech motor cortex of a subject while the subject produces or imagines producing a speech sound. The methods further include deriving a speech production signal pattern from the detected speech production signals, and correlating the speech production signal pattern with a reference speech production signal pattern to decode speech from the brain of the subject. Speech communication systems and devices for practicing the subject methods are also provided.