Patents by Inventor Edward F. Plow

Edward F. Plow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for diagnosing chronic immune thrombocytopenic purpura
    Patent number: 5177188
    Abstract: A polypeptide consisting essentially of an amino acid residue sequence selected from the group consisting of:Tyr-His-Asp-Arg-Lys-Glu-Phe-Ala-Lys-Phe-Glu-Glu-Glu-Arg-Ala- Arg-Ala-Lys-Trp-Asp-Thr-Ala-Asn-Asn; SEQ ID No 1 andAla-Asn-Asn-Pro-Leu-Tyr-Lys-Glu-Ala-Thr- Ser-Thr-Phe-Thr-Asn-Ile-Thr-Tyr-Arg-Gly-Thr, SEQ ID No 2.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: January 5, 1993
    Assignee: The Scripps Research Institute
    Inventors: Mark H. Ginsberg, Robert McMillan, Edward F. Plow
  • Peptides and antibodies that inhibit integrin-ligand binding
    Patent number: 5149780
    Abstract: Polypeptides which are derived from the Arg-Gly-Asp (RGD) binding portion of an Integrin beta subunit are disclosed as are their use for modulation of Integrin ligand binding. Anti-antibody peptides, hybridomas secreting these antibodies, as well as methods of making any using such antibodies, and recombinant DNA molecules that define the structural gene coding for the polypeptides are also contemplated within the scope of the present invention.
    Type: Grant
    Filed: October 3, 1988
    Date of Patent: September 22, 1992
    Assignee: The Scripps Research Institute
    Inventors: Edward F. Plow, Stanley E. D'Souza, Mark H. Ginsberg
  • Peptides and antibodies that inhibit platelet adhesion
    Patent number: 5114842
    Abstract: A polypeptide analog capable of immunologically mimicking a linear hGPIIb antigenic determinant expressed when platelet-associated GPIIb-IIIa binds fibrinogen is disclosed. An antibody that immunoreacts with the polypeptide and hGPIIb when hGPIIb is present as a platelet-associated GPPIb-IIIa/fibrinogen complex is also disclosed. Further disclosed are diagnostic systems and methods for assaying fibrinogen-bound platelets in a vascular fluid sample using the polypeptides and/or antibodies of the invention.
    Type: Grant
    Filed: March 31, 1988
    Date of Patent: May 19, 1992
    Assignee: The Scripps Research Institute
    Inventors: Edward F. Plow, Mark H. Ginsberg
  • Detection of activated platelets with antibodies to thrombospondin
    Patent number: 4820505
    Abstract: A diagnostic site-specific imaging reagent in the form of a receptor and an indicating means selectively binds to a specific cell membrane-associated antigen of a blood platelet that is in a stimulated active state but does not substantially bind to a platelet that is in a non-stimulated resting state. In particular, prelabelled monoclonal antibodies and polyclonal antibodies are prepared that bind and image thrombospondin when it is cell membrane-associated on a thrombin-stimulated platelet, thereby providing means for detecting and discriminating between a stimulated active blood platelet and a non-stimulated resting blood platelet.
    Type: Grant
    Filed: April 4, 1985
    Date of Patent: April 11, 1989
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Mark H. Ginsberg, Edward F. Plow
  • Carcinoembryonic antigen isomer
    Patent number: 4145336
    Abstract: The discovery of an isomeric species of carcinoembryonic antigen and methods of isolation, identification and utilization of the same as an aid in the diagnosis of adenocarcinomas of the gastrointenstinal tract are disclosed.
    Type: Grant
    Filed: April 30, 1976
    Date of Patent: March 20, 1979
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Thomas S. Edgington, Edward F. Plow
  • Diagnostic method and reagent
    Patent number: 4140753
    Abstract: The discovery of an isomeric species of carcinoembryonic antigen and methods of isolation, identification and utilization as a radiolabelled species of the same as an aid in the diagnosis of adenocarcinomas of the gastrointestinal tract are disclosed.
    Type: Grant
    Filed: April 30, 1976
    Date of Patent: February 20, 1979
    Assignee: Scripps Clinic & Research Foundation
    Inventors: Thomas S. Edgington, Edward F. Plow