Patents by Inventor Edward F. Rehberg

Edward F. Rehberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thrombolytic agents with modified kringle domains
    Patent number: 5275946
    Abstract: This invention relates to analogs of thrombolytic agents having a modified kringle domain. More specifically, this invention is directed to TPA type compounds wherein modifications occur in the kringle 1 and kringle 2 domains. This invention is also directed to analogs with one or more changes in the kringle domain of urokinase-type compounds. The compounds of this invention are pharmaceutically useful having particular use in the same manner as TPA and urokinase.
    Type: Grant
    Filed: June 7, 1991
    Date of Patent: January 4, 1994
    Assignee: Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek Tno
    Inventors: Nicole T. Hatzenbuhler, Keith R. Marotti, Edward F. Rehberg, Johan H. Verheyen
  • Tissue plasminogen activator (TPA) analogs
    Patent number: 5106741
    Abstract: This invention discloses human tissue plasminogen activator (TPA) analogs. The analogs are TPA-like molecules that have had the native domain regions either rearranged, delected, added or a combination thereof. The analogs are the product of the expression of recombinant DNA also described herein. Additonally, the present invention described replication and expression plasmids containing the TPA-coding DNA sequences described above and suitable host microorganisms that are capable of expressing the TPA analogs after becoming transformed with an appropriate plasmid.
    Type: Grant
    Filed: June 12, 1991
    Date of Patent: April 21, 1992
    Assignee: The Upjohn Company
    Inventors: Keith R. Marotti, Edward F. Rehberg, Nicole Y. Theriault