Abstract: Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are z-2-acylamino-3-monosubstituted propenoates.

Abstract: Novel chemical compounds are provided which selectively inhibit the metabolism of renal dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are (Z,Z)-.alpha.,.alpha.'-bis(2,2-disubstituted cyclopropanecarboxamido)-.alpha.,.alpha.'-alkadienedioic acids.

Abstract: Novel 3-amino or substituted amino pyrazoles are disclosed as having antiprotozoal and antiparasitic activity in particular anticoccidial activity and are useful for controlling cecal and or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.

Abstract: Traumatin, 12-oxo-trans (E) -10-docecenoic acid, is prepared from 10-oxomethyldecanoate by reaction with (triphenylphosphoranylene)acetaldehyde to form 12-oxomethyldodecenoate; blocking the 12-oxo group; hydrolyzing the ester group; and deblocking the 12-oxo group.

Abstract: The novel compound 7-methyl-8-methylamino-10-(1'-D-ribityl)isoalloxazine is prepared. This compound has anticoccidial, antiprotozoal and antiparasitic activity. It is particularly useful for controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.

Abstract: The novel compound 9-azariboflavin is prepared. This compound has anticoccidial, antiprotozoal and antiparasitic activity. It is particularly useful for controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.

Abstract: 5-Deazariboflavin, its phosphate ester and nontoxic salts thereof and its novel bis(loweralkoxymethylene) derivatives have antiprotozoal and antiparasitic activity. They are particularly useful for controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance. The compounds are included in compositions useful for the prevention and treatment of coccidiosis in poultry.

Abstract: 5-Deazariboflavin, its phosphate ester and non-toxic salts thereof and its novel bis(loweralkoxymethylene) derivatives have antiprotozoal and antiparasitic activity. They are particularly useful for controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance. The compounds are included in compositions useful for the prevention and treatment of coccidiosis in poultry.

Abstract: Novel compounds of the following formula: ##STR1## wherein R' is alkyl of 1 to 3 carbon atoms, X.sup.- is a nontoxic anion; b and c are positive numbers having values such that the positive charge of b moles of cation are neutralized by c moles of anion X.sup.- ; and -.sup.+ is a bicyclic heterocyclic base, of the group consisting of: ##STR2## wherein the dotted lines indicates that the methyl group can be present or a hydrogen group can be present, with the proviso that the two alpha methyl groups are not present at the same time, but that one alpha methyl group is required. These compounds have superior coccidiostatic activity.

Abstract: New benzimidazoles substituted at the 1-position with carbonyl substituents and at the 2-position with a 4-thiazolyl group are effective fungicides and anthelmintics. The compounds as well as processes for their preparation are described along with antifungal and anthelmintic compositions for their use. The 1-position substituent is a hydrocarbon group of from 5 to 12 carbon atoms connected to the carbonyl group through an oxygen or a sulfur atom. The compounds are generally prepared by contacting a 1-unsubstituted benzimidazole with a hydrocarbon radical substituted chloroformate or chlorothiol formate.

Abstract: New water soluble benzimidazoles with a high degree of stability, which are substituted at the 1-position with carboxyalkoxycarbonyl substituents and at the 2-position with a 4-thiazolyl group are effective fungicides and anthelmintics. The compounds as well as processes for their preparation are described along with antifungal and anthelmintic compositions for their use. The 1-position substituent is a carboxyalkoxycarbonyl group of from 3 to 11 carbon atoms including certain salts and derivatives of the carboxy group. The compounds are generally prepared by contacting a 1-unsubstituted benzimidazole with a protected carboxyalkoxycarbonyl chloride.

Abstract: New benzimidazoles substituted at the 1-position with carbonyl substituents and at the 2-position with a 4-thiazolyl group are effective fungicides and anthelmintics exhibiting particularly useful hydrophilic and lypophilic effects. The compounds as well as processes for their preparation are described along with antifungal and anthelmintic compositions for their use. The 1-position substituent is a loweralkoxy or phenylloweralkoxy substituted ethoxy or polyethoxy carbonyl group of a chain with up to 4 ethoxy groups connected to the carbonyl. The compounds are generally prepared by contacting a 1-unsubstituted benzimidazole with a loweralkoxy or phenylloweralkoxy substituted ethoxy or polyethoxy chloroformate.

Abstract: Novel compounds of the following formula: ##STR1## WHEREIN R' is alkyl of 1 to 3 carbon atoms, X.sup.- is a nontoxic anion; b and c are positive numbers having values such that the positive charge of b moles of cation are neutralized by c moles of anion X.sup.-; and -N is a bicyclic heterocyclic base, of the group consisting of: ##STR2## wherein the dotted line indicates that the methyl group can be present or a hydrogen group can be present, with the proviso that the two alpha methyl groups are not present at the same time, but that one alpha methyl group is required. These compounds have superior coccidiostatic activity.

Abstract: 4-Nitro-5-cyanoimidazoles substituted with a 1-loweralkyl group and variously substituted at the 2-position are useful as antiparasitic agents particularly as coccidiostats. The 4-nitro-5-cyanoimidazole coccidiostats are included in compositions useful for administration to poultry as treatment for coccidiosis.

Abstract: Substituted 2- and 4-pyridones, pyrimidin-2- and 6-ones and tetrahydroquinolones when complexed with 4,4'-dinitrocarbanilide provide agents which are active coccidiostats and which produce minimal toxic side effects. Processes for the preparation of these complexes as well as compositions suitable for administration to poultry for the prevention and cure of coccidiosis are also disclosed.