Abstract: A vented end cap for an outlet gate comprises a generally cylindrical body, a disc-shaped end wall with at least one flow aperture; a vent hood on the exterior of the end wall defines an air flow passage having an inlet opening and communicates with the flow aperture; a filter support housing on the interior surface of the end wall, defines an air flow chamber having an exit opening communicating with the flow aperture, and with the interior of the vented end cap. A filter media is supported on filter support housing between the flow aperture and the exit opening. A railroad car outlet gate includes one of the vented end caps at each end of a discharge tube with outlet openings at each end. A method includes removal of one vented end cap and applying a vacuum to the uncovered discharge opening. In one form, a filter clean seal is disposed at each outlet opening.

Abstract: A vented end cap for an outlet gate comprises a generally cylindrical body, a disc-shaped end wall with at least one flow aperture; a vent hood on the exterior of the end wall defines an air flow passage having an inlet opening and communicates with the flow aperture; a filter support housing on the interior surface of the end wall, defines an air flow chamber having an exit opening communicating with the flow aperture, and with the interior of the vented end cap. A filter media is supported on filter support housing between the flow aperture and the exit opening. A railroad car outlet gate includes one of the vented end caps at each end of a discharge tube with outlet openings at each end. A method includes removal of one vented end cap and applying a vacuum to the uncovered discharge opening. In one form, a filter clean seal is disposed at each outlet opening.

Abstract: The present invention relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.

Abstract: The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to JNK3 or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.

Abstract: The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site-binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to JNK3 or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.